We are analyzing https://link.springer.com/article/10.1186/s13075-016-1156-1.

Title:
Rheumatoid synovial fibroblasts differentiate into distinct subsets in the presence of cytokines and cartilage | Arthritis Research & Therapy
Description:
Background We investigated two distinct synovial fibroblast populations that were located preferentially in the lining or sub-lining layers and defined by their expression of either podoplanin (PDPN) or CD248, and explored their ability to undergo self-assembly and transmigration in vivo. Methods Synovial fibroblasts (SF) were cultured in vitro and phenotypic changes following stimulation with interleukin (IL)-1β, tumor necrosis factor (TNF)-α, and transforming growth factor (TGF)-β1 were examined. To examine the phenotype of SF in vivo, a severe combined immunodeficiency (SCID) human-mouse model of cartilage destruction was utilised. Results SF in the lining layer in rheumatoid arthritis (RA) expressed high levels of PDPN compared to the normal synovium, whereas CD248 expression was restricted to sub-lining layer cells. TNF-α or IL1 stimulation in vitro resulted in an increased expression of PDPN. In contrast, stimulation with TGF-β1 induced CD248 expression. In the SCID human-mouse model, rheumatoid SF recapitulated the expression of PDPN and CD248. Fibroblasts adjacent to cartilage expressed PDPN, and attached to, invaded, and degraded cartilage. PDPN+ CD248– SF preceded the appearance of PDPN– CD248+ cells in contralateral implants. Conclusions We have identified two distinct SF populations identified by expression of either PDPN or CD248 which are located within different anatomical compartments of the inflamed synovial membrane. These markers discriminate between SF subsets with distinct biological properties. As PDPN-expressing cells are associated with early fibroblast migration and cartilage erosion in vivo, we propose that PDPN-expressing cells may be an attractive therapeutic target in RA.
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Keywords {🔍}

pdpn, cells, expression, cartilage, fibroblasts, pubmed, synovial, arthritis, article, rheumatoid, tissue, cell, google, scholar, layer, expressed, rasf, fibroblast, markers, lining, cas, human, synovium, fig, implant, central, scid, sublining, secondary, distinct, primary, research, mice, mouse, time, data, podoplanin, factor, patients, subsets, number, vivo, sections, birmingham, shown, percentage, normal, buckley, vitro, stimulation,

Topics {✒️}

gov/ij/plugins/cell-counter jean-michel dayer intraclass correlation coefficients lymphatic endothelial cells severe combined immunodeficiency ultrasound-guided synovial biopsy ulf müller-ladner justus-liebig-university giessen synovial fluid-derived fibroblast tumor necrosis factor species-specific anticd248 antibody quantitative rt-pcr expressed article download pdf fibroblast activation protein resulting cell/tissue mixture full access arthritis research uk apc-conjugated antihuman cd90 protein disulfide isomerase persistent synovial inflammation transforming growth factor birmingham research laboratories rheumatoid arthritis generated high-magnification confocal images rheumatoid synovial fluid pcr master mix rheumatoid synovial fibroblasts privacy choices/manage cookies adherent fibroblast colonies synovial macrophages defines real-time pcr scid human-mouse model müller-ladner springer semin immunopathol gratefully acknowledge funding centre médical universitaire rheumatoid synovial tissue rheumatoid arthritis attach �cell counter” plugin facscanto ii system related subjects trans-membrane proteins local ethics committee creative commons license specific fibroblast subsets fibroblast-targeted treatments fibroblast platelet crosstalk stromal cell section arthritis res ther buckley cd

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MMPs and rheumatoid synovial fibroblasts: Siamese twins in joint destruction?

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         Orthopedics
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            address:
               name:University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK
               type:PostalAddress
            type:Organization
      name:Christopher D. Buckley
      affiliation:
            name:University of Birmingham Research Laboratories, Queen Elizabeth Hospital Birmingham
            address:
               name:Rheumatology Research Group, Institute of Inflammation and Ageing, University of Birmingham Research Laboratories, Queen Elizabeth Hospital Birmingham, Birmingham, UK
               type:PostalAddress
            type:Organization
            name:Sandwell and West Birmingham Hospitals NHS Trust
            address:
               name:Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, UK
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Rheumatology Research Group, Institute of Inflammation and Ageing, University of Birmingham Research Laboratories, Queen Elizabeth Hospital Birmingham, Birmingham, UK
      name:Rheumatology Research Group, Institute of Inflammation and Ageing, University of Birmingham Research Laboratories, Queen Elizabeth Hospital Birmingham, Birmingham, UK
      name:Rheumatology Research Group, Institute of Inflammation and Ageing, University of Birmingham Research Laboratories, Queen Elizabeth Hospital Birmingham, Birmingham, UK
      name:Rheumatology Research Group, Institute of Inflammation and Ageing, University of Birmingham Research Laboratories, Queen Elizabeth Hospital Birmingham, Birmingham, UK
      name:Department of Internal Medicine and Rheumatology, Justus-Liebig-University Giessen, Kerckhoff-Klinik, Bad Nauheim, Germany
      name:Rheumatology Research Group, Institute of Inflammation and Ageing, University of Birmingham Research Laboratories, Queen Elizabeth Hospital Birmingham, Birmingham, UK
      name:Rheumatology Research Group, Institute of Inflammation and Ageing, University of Birmingham Research Laboratories, Queen Elizabeth Hospital Birmingham, Birmingham, UK
      name:Rheumatology Research Group, Institute of Inflammation and Ageing, University of Birmingham Research Laboratories, Queen Elizabeth Hospital Birmingham, Birmingham, UK
      name:Rheumatology Research Group, Institute of Inflammation and Ageing, University of Birmingham Research Laboratories, Queen Elizabeth Hospital Birmingham, Birmingham, UK
      name:Department of Internal Medicine and Rheumatology, Justus-Liebig-University Giessen, Kerckhoff-Klinik, Bad Nauheim, Germany
      name:Faculty of Medicine, Centre Médical Universitaire, Geneva, Switzerland
      name:Department of Internal Medicine and Rheumatology, Justus-Liebig-University Giessen, Kerckhoff-Klinik, Bad Nauheim, Germany
      name:Rheumatology Research Group, Institute of Inflammation and Ageing, University of Birmingham Research Laboratories, Queen Elizabeth Hospital Birmingham, Birmingham, UK
      name:University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK
      name:Rheumatology Research Group, Institute of Inflammation and Ageing, University of Birmingham Research Laboratories, Queen Elizabeth Hospital Birmingham, Birmingham, UK
      name:Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, UK

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