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Keywords {🔍}

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Topics {✒️}

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         headline:Cancer Genome Interpreter annotates the biological and clinical relevance of tumor alterations
         description:While tumor genome sequencing has become widely available in clinical and research settings, the interpretation of tumor somatic variants remains an important bottleneck. Here we present the Cancer Genome Interpreter, a versatile platform that automates the interpretation of newly sequenced cancer genomes, annotating the potential of alterations detected in tumors to act as drivers and their possible effect on treatment response. The results are organized in different levels of evidence according to current knowledge, which we envision can support a broad range of oncology use cases. The resource is publicly available at http://www.cancergenomeinterpreter.org .
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         name:Vall d’Hebron Institute of Oncology, Vall d’Hebron University Hospital, Autonomous University of Barcelona, Barcelona, Spain
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         name:Research Program on Biomedical Informatics (GRIB), IMIM Hospital del Mar Medical, Research Institute and Pompeu Fabra University, Barcelona, Spain
         type:PostalAddress
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         name:Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain
         type:PostalAddress
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      address:
         name:Research Program on Biomedical Informatics (GRIB), IMIM Hospital del Mar Medical, Research Institute and Pompeu Fabra University, Barcelona, Spain
         type:PostalAddress
      name:Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology
      address:
         name:Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain
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            name:IMIM Hospital del Mar Medical, Research Institute and Pompeu Fabra University
            address:
               name:Research Program on Biomedical Informatics (GRIB), IMIM Hospital del Mar Medical, Research Institute and Pompeu Fabra University, Barcelona, Spain
               type:PostalAddress
            type:Organization
            name:Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology
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               name:Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain
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      name:Carlota Rubio-Perez
      affiliation:
            name:IMIM Hospital del Mar Medical, Research Institute and Pompeu Fabra University
            address:
               name:Research Program on Biomedical Informatics (GRIB), IMIM Hospital del Mar Medical, Research Institute and Pompeu Fabra University, Barcelona, Spain
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      affiliation:
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            address:
               name:Research Program on Biomedical Informatics (GRIB), IMIM Hospital del Mar Medical, Research Institute and Pompeu Fabra University, Barcelona, Spain
               type:PostalAddress
            type:Organization
            name:Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology
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            address:
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               type:PostalAddress
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            address:
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               type:PostalAddress
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            name:Pompeu Fabra University
            address:
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               type:PostalAddress
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      affiliation:
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            address:
               name:Vall d’Hebron Institute of Oncology, Vall d’Hebron University Hospital, Autonomous University of Barcelona, Barcelona, Spain
               type:PostalAddress
            type:Organization
      name:Josep Tabernero
      affiliation:
            name:Vall d’Hebron University Hospital, Autonomous University of Barcelona
            address:
               name:Vall d’Hebron Institute of Oncology, Vall d’Hebron University Hospital, Autonomous University of Barcelona, Barcelona, Spain
               type:PostalAddress
            type:Organization
      name:Carmen de Torres
      affiliation:
            name:Developmental Tumor Biology Laboratory, Institut de Recerca Pediàtrica- Hospital Sant Joan de Déu Barcelona
            address:
               name:Developmental Tumor Biology Laboratory, Institut de Recerca Pediàtrica- Hospital Sant Joan de Déu Barcelona, Barcelona, Spain
               type:PostalAddress
            type:Organization
      name:Rodrigo Dienstmann
      affiliation:
            name:Vall d’Hebron University Hospital, Autonomous University of Barcelona
            address:
               name:Vall d’Hebron Institute of Oncology, Vall d’Hebron University Hospital, Autonomous University of Barcelona, Barcelona, Spain
               type:PostalAddress
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      affiliation:
            name:IMIM Hospital del Mar Medical, Research Institute and Pompeu Fabra University
            address:
               name:Research Program on Biomedical Informatics (GRIB), IMIM Hospital del Mar Medical, Research Institute and Pompeu Fabra University, Barcelona, Spain
               type:PostalAddress
            type:Organization
            name:Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology
            address:
               name:Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain
               type:PostalAddress
            type:Organization
      name:Nuria Lopez-Bigas
      affiliation:
            name:IMIM Hospital del Mar Medical, Research Institute and Pompeu Fabra University
            address:
               name:Research Program on Biomedical Informatics (GRIB), IMIM Hospital del Mar Medical, Research Institute and Pompeu Fabra University, Barcelona, Spain
               type:PostalAddress
            type:Organization
            name:Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology
            address:
               name:Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain
               type:PostalAddress
            type:Organization
            name:Institució Catalana de Recerca i Estudis Avançats (ICREA)
            address:
               name:Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Research Program on Biomedical Informatics (GRIB), IMIM Hospital del Mar Medical, Research Institute and Pompeu Fabra University, Barcelona, Spain
      name:Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain
      name:Research Program on Biomedical Informatics (GRIB), IMIM Hospital del Mar Medical, Research Institute and Pompeu Fabra University, Barcelona, Spain
      name:Research Program on Biomedical Informatics (GRIB), IMIM Hospital del Mar Medical, Research Institute and Pompeu Fabra University, Barcelona, Spain
      name:Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain
      name:Research Program on Biomedical Informatics (GRIB), IMIM Hospital del Mar Medical, Research Institute and Pompeu Fabra University, Barcelona, Spain
      name:Charité – Universitätsmedizin Berlin, Berlin, Germany
      name:Vall d’Hebron Institute of Oncology, Vall d’Hebron University Hospital, Autonomous University of Barcelona, Barcelona, Spain
      name:Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain
      name:Department of Oncology, Hospital del Mar- CIBERONC, Barcelona, Spain
      name:Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain
      name:Department of Oncology, Hospital del Mar- CIBERONC, Barcelona, Spain
      name:Autonomous University of Barcelona, Barcelona, Spain
      name:Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain
      name:Department of Oncology, Hospital del Mar- CIBERONC, Barcelona, Spain
      name:Pompeu Fabra University, Barcelona, Spain
      name:Vall d’Hebron Institute of Oncology, Vall d’Hebron University Hospital, Autonomous University of Barcelona, Barcelona, Spain
      name:Vall d’Hebron Institute of Oncology, Vall d’Hebron University Hospital, Autonomous University of Barcelona, Barcelona, Spain
      name:Developmental Tumor Biology Laboratory, Institut de Recerca Pediàtrica- Hospital Sant Joan de Déu Barcelona, Barcelona, Spain
      name:Vall d’Hebron Institute of Oncology, Vall d’Hebron University Hospital, Autonomous University of Barcelona, Barcelona, Spain
      name:Research Program on Biomedical Informatics (GRIB), IMIM Hospital del Mar Medical, Research Institute and Pompeu Fabra University, Barcelona, Spain
      name:Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain
      name:Research Program on Biomedical Informatics (GRIB), IMIM Hospital del Mar Medical, Research Institute and Pompeu Fabra University, Barcelona, Spain
      name:Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain
      name:Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain

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