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TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression | Genome Medicine
Description:
Human cancer cell lines are an important resource for research and drug development. However, the available annotations of cell lines are sparse, incomplete, and distributed in multiple repositories. Re-analyzing publicly available raw RNA-Seq data, we determined the human leukocyte antigen (HLA) type and abundance, identified expressed viruses and calculated gene expression of 1,082 cancer cell lines. Using the determined HLA types, public databases of cell line mutations, and existing HLA binding prediction algorithms, we predicted antigenic mutations in each cell line. We integrated the results into a comprehensive knowledgebase. Using the Django web framework, we provide an interactive user interface with advanced search capabilities to find and explore cell lines and an application programming interface to extract cell line information. The portal is available at http://celllines.tron-mainz.de .
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Keywords {π}
cell, hla, line, cancer, pubmed, article, lines, data, type, expression, google, scholar, class, gene, information, human, search, rnaseq, cas, genome, virus, reads, neoepitope, central, interface, determined, mutations, binding, mutation, portal, predicted, access, boegel, catalog, fig, tclp, annotations, types, integrated, user, ccle, table, sequence, rpkm, typing, including, sebastian, antigen, expressed, viruses,
Topics {βοΈ}
human leukocyte antigen cancer-specific peptide-hla complexes paired-end rna-seq samples viral-related human carcinogenesis 101Β nt paired-end sequencing 75Β nt paired-end sequencing class ii neo-epitopes accurate pan-specific prediction class ii neo-antigens article download pdf european genome-phenome archive neo-epitope prediction based raw rna-seq data human endogenous retrovirus including rna-seq datasets antigen presentation datasets rna-seq datasets analyzing rna-seq data uk/ega/datasets/egad00001000725 cancer-related virus infections virus-related hepatocellular carcinoma explore cell lines calculate gene-level expression rna-seq sequence reads processed rna-seq data class ii type human reference genome web-based user interface class ii types cell line origin cell line annotation selected cell line current cell line rna-seq analysis predicted neo-epitopes cell line information cell line mutations cell line annotations class ii genotypes johannes gutenberg-university mainz cell line primary national cancer institute privacy choices/manage cookies predicted hla class specific hla type neo-epitope candidates sequence alignment/map format rna-seq data targeted pcr amplification cell lines a375
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headline:TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression
description:Human cancer cell lines are an important resource for research and drug development. However, the available annotations of cell lines are sparse, incomplete, and distributed in multiple repositories. Re-analyzing publicly available raw RNA-Seq data, we determined the human leukocyte antigen (HLA) type and abundance, identified expressed viruses and calculated gene expression of 1,082 cancer cell lines. Using the determined HLA types, public databases of cell line mutations, and existing HLA binding prediction algorithms, we predicted antigenic mutations in each cell line. We integrated the results into a comprehensive knowledgebase. Using the Django web framework, we provide an interactive user interface with advanced search capabilities to find and explore cell lines and an application programming interface to extract cell line information. The portal is available at
http://celllines.tron-mainz.de
.
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headline:TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression
description:Human cancer cell lines are an important resource for research and drug development. However, the available annotations of cell lines are sparse, incomplete, and distributed in multiple repositories. Re-analyzing publicly available raw RNA-Seq data, we determined the human leukocyte antigen (HLA) type and abundance, identified expressed viruses and calculated gene expression of 1,082 cancer cell lines. Using the determined HLA types, public databases of cell line mutations, and existing HLA binding prediction algorithms, we predicted antigenic mutations in each cell line. We integrated the results into a comprehensive knowledgebase. Using the Django web framework, we provide an interactive user interface with advanced search capabilities to find and explore cell lines and an application programming interface to extract cell line information. The portal is available at
http://celllines.tron-mainz.de
.
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