We are analyzing https://link.springer.com/article/10.1186/s13059-017-1347-3.

Title:
Rewriting the transcriptome: adenosine-to-inosine RNA editing by ADARs | Genome Biology
Description:
One of the most prevalent forms of post-transcritpional RNA modification is the conversion of adenosine nucleosides to inosine (A-to-I), mediated by the ADAR family of enzymes. The functional requirement and regulatory landscape for the majority of A-to-I editing events are, at present, uncertain. Recent studies have identified key in vivo functions of ADAR enzymes, informing our understanding of the biological importance of A-to-I editing. Large-scale studies have revealed how editing is regulated both in cis and in trans. This review will explore these recent studies and how they broaden our understanding of the functions and regulation of ADAR-mediated RNA editing.
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Keywords {🔍}

editing, pubmed, adar, rna, article, google, scholar, cas, central, atoi, cell, human, adenosine, sites, regulation, adars, biol, activity, nat, sequence, expression, function, genome, deaminase, identified, dsrna, drosophila, specific, protein, analysis, transcriptome, gene, identification, proteins, mammalian, studies, species, levels, cis, regions, mutations, cancer, science, res, site, functions, doublestranded, sequencing, important, phenotypes,

Topics {✒️}

double-stranded-rna-specific adenosine deaminase cdc14b/skp2/p21/p27 axis rna-editing-mediated exon evolution editing activity/catalytic domain double-stranded rna substrate disrupting mir-30b-3p article download pdf central nervous system lps-stimulated immune cells innate immune/interferon response jin billy li post-transcritpional rna modification rna-editing enzyme adar1 double-stranded rna rna-editing enzyme adar2 direct interferon-stimulated gene post-transcriptional gene regulation rna editing/interacting potential rna-induced gene silencing high-throughput sequencing technologies innate immune sensing adar1-mediated editing leads adar-mediated rna editing adar-mediated rna-editing george cx quantitative trait locus full size image transcription factor period human cell line cis-acting regulatory elements innate immune system adar1-mediated rna editing query rna-editing sites adar2-mediated rna editing exclude context-specific functions innate immune response stress-induced apoptosis demonstrated catalytic activity adar1-related neurological disease adar-mediated editing resulting dadar-dependent rna editing rna-interacting proteins act antisense rna injections adenosine deaminase acting putative double-strandedness privacy choices/manage cookies dyschromatosis symmetrica hereditaria cytosolic dna metabolism identify hyper-editing sites adar protein activity/levels

Questions {❓}

ADARs, editing, and disease: what happens when editing goes awry?

Schema {🗺️}

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         headline:Rewriting the transcriptome: adenosine-to-inosine RNA editing by ADARs
         description:One of the most prevalent forms of post-transcritpional RNA modification is the conversion of adenosine nucleosides to inosine (A-to-I), mediated by the ADAR family of enzymes. The functional requirement and regulatory landscape for the majority of A-to-I editing events are, at present, uncertain. Recent studies have identified key in vivo functions of ADAR enzymes, informing our understanding of the biological importance of A-to-I editing. Large-scale studies have revealed how editing is regulated both in cis and in trans. This review will explore these recent studies and how they broaden our understanding of the functions and regulation of ADAR-mediated RNA editing.
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            Animal Genetics and Genomics
            Human Genetics
            Plant Genetics and Genomics
            Microbial Genetics and Genomics
            Bioinformatics
            Evolutionary Biology
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      headline:Rewriting the transcriptome: adenosine-to-inosine RNA editing by ADARs
      description:One of the most prevalent forms of post-transcritpional RNA modification is the conversion of adenosine nucleosides to inosine (A-to-I), mediated by the ADAR family of enzymes. The functional requirement and regulatory landscape for the majority of A-to-I editing events are, at present, uncertain. Recent studies have identified key in vivo functions of ADAR enzymes, informing our understanding of the biological importance of A-to-I editing. Large-scale studies have revealed how editing is regulated both in cis and in trans. This review will explore these recent studies and how they broaden our understanding of the functions and regulation of ADAR-mediated RNA editing.
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         Adenosine Deaminase Acting On RNA (ADAR)
         ADAR Family
         ADAR Enzymes
         Editing Events
         ADAR Proteins
         Animal Genetics and Genomics
         Human Genetics
         Plant Genetics and Genomics
         Microbial Genetics and Genomics
         Bioinformatics
         Evolutionary Biology
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                  name:University of Melbourne
                  address:
                     name:Department of Medicine, St Vincent’s Hospital, University of Melbourne, Fitzroy, Australia
                     type:PostalAddress
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      name:Department of Medicine, St Vincent’s Hospital, University of Melbourne, Fitzroy, Australia
      name:Department of Genetics, Stanford University, Stanford, USA

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