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models, rnaseq, gene, expression, prediction, clinical, neuroblastoma, pubmed, article, data, google, scholar, genes, additional, file, cas, performances, analysis, endpoint, cancer, microarrays, endpoints, patients, microarray, research, usa, microarraybased, validation, model, university, aceview, fig, degs, features, center, information, profiles, reads, performance, study, transcript, genome, results, predictive, figure, central, expressed, expressionbased, table, based,

Topics {✒️}

retrospective siopen/cog/gpoh study gov/repository/acedb/software/magic gene expression-based classifiers gene expression profiling fördergesellschaft kinderkrebs-neuroblastom-forschung gene expression-based prediction gene expression-based classification high-throughput shotgun sequencing bldg 38a/room 8s808 danielle thierry-mieg major clinico-genetic subtypes microarray-based expression data rt-qpcr-based assays [6 gene-level analysis failed prognostic multi-gene signature expression profiling technology color gene-expression analyses article download pdf comprehensive cdna-supported gene jean thierry-mieg high-risk patient outcome outperform microarray-based models rna-seq expression data clinico-genetic neuroblastoma subgroups prognostic microrna/mrna signature kaplan-meier survival estimates rna-seq outperforms microarrays rna-seq-based classifiers rna-seq data compares microarray-based predictive models current high-risk patients gene expression analysis rna-seq-based models rna-seq based models rna-seq processing pipelines gene expression profiles internal cross-validation processes rna-seq processing pipeline rna-seq data processing supplementary figures s1–s13 supplementary tables s1–s9 raw rna-seq data gene expression measurements gene expression levels gene expression models transcript-level expression values maqc-iii project utilizing expression-based classifiers complex expression patterns expression profiling

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         headline:Comparison of RNA-seq and microarray-based models for clinical endpoint prediction
         description:Gene expression profiling is being widely applied in cancer research to identify biomarkers for clinical endpoint prediction. Since RNA-seq provides a powerful tool for transcriptome-based applications beyond the limitations of microarrays, we sought to systematically evaluate the performance of RNA-seq-based and microarray-based classifiers in this MAQC-III/SEQC study for clinical endpoint prediction using neuroblastoma as a model. We generate gene expression profiles from 498 primary neuroblastomas using both RNA-seq and 44 k microarrays. Characterization of the neuroblastoma transcriptome by RNA-seq reveals that more than 48,000 genes and 200,000 transcripts are being expressed in this malignancy. We also find that RNA-seq provides much more detailed information on specific transcript expression patterns in clinico-genetic neuroblastoma subgroups than microarrays. To systematically compare the power of RNA-seq and microarray-based models in predicting clinical endpoints, we divide the cohort randomly into training and validation sets and develop 360 predictive models on six clinical endpoints of varying predictability. Evaluation of factors potentially affecting model performances reveals that prediction accuracies are most strongly influenced by the nature of the clinical endpoint, whereas technological platforms (RNA-seq vs. microarrays), RNA-seq data analysis pipelines, and feature levels (gene vs. transcript vs. exon-junction level) do not significantly affect performances of the models. We demonstrate that RNA-seq outperforms microarrays in determining the transcriptomic characteristics of cancer, while RNA-seq and microarray-based models perform similarly in clinical endpoint prediction. Our findings may be valuable to guide future studies on the development of gene expression-based predictive models and their implementation in clinical practice.
         datePublished:2015-06-25T00:00:00Z
         dateModified:2015-06-25T00:00:00Z
         pageStart:1
         pageEnd:12
         license:http://creativecommons.org/licenses/by/4.0/
         sameAs:https://doi.org/10.1186/s13059-015-0694-1
         keywords:
            Overall Survival
            Neuroblastoma
            Prediction Performance
            Clinical Endpoint
            Gene Expression Model
            Animal Genetics and Genomics
            Human Genetics
            Plant Genetics and Genomics
            Microbial Genetics and Genomics
            Bioinformatics
            Evolutionary Biology
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               name:Tieliu Shi
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                        name:Department of Pediatric Oncology and Hematology, University Children’s Hospital of Cologne, Cologne, Germany
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                        name:University of Cologne, Center for Molecular Medicine (CMMC), Medical Faculty, Cologne, Germany
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                        name:Department of Biology, University of Copenhagen, Copenhagen, Denmark
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                        name:King Abdulaziz University, Jeddah, Saudi Arabia
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                     name:University Children’s Hospital of Cologne
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                     name:University of Cologne, Center for Molecular Medicine (CMMC), Medical Faculty
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                        name:University of Cologne, Center for Molecular Medicine (CMMC), Medical Faculty, Cologne, Germany
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ScholarlyArticle:
      headline:Comparison of RNA-seq and microarray-based models for clinical endpoint prediction
      description:Gene expression profiling is being widely applied in cancer research to identify biomarkers for clinical endpoint prediction. Since RNA-seq provides a powerful tool for transcriptome-based applications beyond the limitations of microarrays, we sought to systematically evaluate the performance of RNA-seq-based and microarray-based classifiers in this MAQC-III/SEQC study for clinical endpoint prediction using neuroblastoma as a model. We generate gene expression profiles from 498 primary neuroblastomas using both RNA-seq and 44 k microarrays. Characterization of the neuroblastoma transcriptome by RNA-seq reveals that more than 48,000 genes and 200,000 transcripts are being expressed in this malignancy. We also find that RNA-seq provides much more detailed information on specific transcript expression patterns in clinico-genetic neuroblastoma subgroups than microarrays. To systematically compare the power of RNA-seq and microarray-based models in predicting clinical endpoints, we divide the cohort randomly into training and validation sets and develop 360 predictive models on six clinical endpoints of varying predictability. Evaluation of factors potentially affecting model performances reveals that prediction accuracies are most strongly influenced by the nature of the clinical endpoint, whereas technological platforms (RNA-seq vs. microarrays), RNA-seq data analysis pipelines, and feature levels (gene vs. transcript vs. exon-junction level) do not significantly affect performances of the models. We demonstrate that RNA-seq outperforms microarrays in determining the transcriptomic characteristics of cancer, while RNA-seq and microarray-based models perform similarly in clinical endpoint prediction. Our findings may be valuable to guide future studies on the development of gene expression-based predictive models and their implementation in clinical practice.
      datePublished:2015-06-25T00:00:00Z
      dateModified:2015-06-25T00:00:00Z
      pageStart:1
      pageEnd:12
      license:http://creativecommons.org/licenses/by/4.0/
      sameAs:https://doi.org/10.1186/s13059-015-0694-1
      keywords:
         Overall Survival
         Neuroblastoma
         Prediction Performance
         Clinical Endpoint
         Gene Expression Model
         Animal Genetics and Genomics
         Human Genetics
         Plant Genetics and Genomics
         Microbial Genetics and Genomics
         Bioinformatics
         Evolutionary Biology
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         name:Genome Biology
         issn:
            1465-6906
         volumeNumber:16
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         name:BioMed Central
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            name:Ying Yu
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                  name:Fudan University
                  address:
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            name:Falk Hertwig
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                  name:University of Cologne, Center for Molecular Medicine (CMMC), Medical Faculty
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            name:Jean Thierry-Mieg
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            name:Cesare Furlanello
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            name:Viswanath Devanarayan
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            name:Barbara Hero
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            name:André Oberthuer
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                  name:University Children’s Hospital of Cologne
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            name:Tao Qing
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                  name:University Children’s Hospital of Cologne
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                     name:Department of Pediatric Oncology and Hematology, University Children’s Hospital of Cologne, Cologne, Germany
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            name:Charles Wang
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                  name:Loma Linda University
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                     name:Center for Genomics and Division of Microbiology & Molecular Genetics, School of Medicine, Loma Linda University, Loma Linda, USA
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            name:May D. Wang
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                  name:GeorgiaTech and Emory University
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            name:Junmei Ai
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                  name:Fondazione Edmund Mach, CRI-CBC
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            name:Shahab Asgharzadeh
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                  name:Schneider Children’s Medical Center of Israel
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            name:Benedikt Brors
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                  name:German Cancer Research Center (DKFZ)
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                     name:Department of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany
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            name:Marco Chierici
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                  name:BGI-Shenzhen, Main Building, Bei Shan Industrial Zone
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            name:Richard G. Grundy
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                  name:University of Nottingham, Children’s Brain Tumour Research Centre, Queen’s Medical Centre, University of Nottingham
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                     name:University of Nottingham, Children’s Brain Tumour Research Centre, Queen’s Medical Centre, University of Nottingham, Nottingham, UK
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            name:Min Max He
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                  name:Rush University Cancer Center
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                     name:Department of Internal Medicine, Rush University Cancer Center, Chicago, USA
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            name:Samir Lababidi
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            name:Xin X. Lu
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                  name:University of Arkansas at Little Rock, UALR/UAMS Joint Bioinformatics Graduate Program
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                     name:University of Arkansas at Little Rock, UALR/UAMS Joint Bioinformatics Graduate Program, Little Rock, USA
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            name:Xiwen Ma
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            name:Baitang Ning
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            name:Rosa Noguera
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                  name:University of Valencia, Medical School
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            name:Martin Peifer
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                  name:University of Cologne, Center for Molecular Medicine (CMMC), Medical Faculty
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         name:BGI-Guangzhou, Guangzhou Higher Education Mega Center, Guangzhou, China
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         name:Department of Pediatric Oncology and Hematology, University Children’s Hospital of Cologne, Cologne, Germany
         type:PostalAddress
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         name:University of Cologne, Center for Molecular Medicine (CMMC), Medical Faculty, Cologne, Germany
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            name:University Children’s Hospital of Cologne
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               name:SAS Institute Inc., Cary, USA
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            name:Marshfield Clinic Research Foundation, Biomedical Informatics Research Center
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               name:Marshfield Clinic Research Foundation, Biomedical Informatics Research Center, Marshfield, USA
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            name:Thomson Reuters IP & Science
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               name:Thomson Reuters IP & Science, Carlsbad, USA
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            name:University Children’s Hospital of Cologne
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               name:Department of Pediatric Oncology and Hematology, University Children’s Hospital of Cologne, Cologne, Germany
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            name:Fudan University
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               name:Collaborative Innovation Center for Genetics and Development, State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences and School of Pharmacy, Fudan University, Shanghai, China
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               name:Department of Pediatric Oncology and Hematology, University Children’s Hospital of Cologne, Cologne, Germany
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            name:Loma Linda University
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               name:Center for Genomics and Division of Microbiology & Molecular Genetics, School of Medicine, Loma Linda University, Loma Linda, USA
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            name:GeorgiaTech and Emory University
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               name:Fondazione Edmund Mach, CRI-CBC, San Michele all’Adige, Italy
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               name:SAS Institute Inc., Cary, USA
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               name:BGI-Shenzhen, Main Building, Bei Shan Industrial Zone, Shenzhen, China
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               name:University of Nottingham, Children’s Brain Tumour Research Centre, Queen’s Medical Centre, University of Nottingham, Nottingham, UK
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               name:Marshfield Clinic Research Foundation, Center of Human Genetics, Marshfield, USA
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               name:National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, USA
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               name:National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, USA
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            name:University of Cologne, Center for Molecular Medicine (CMMC), Medical Faculty
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               name:Department of Translational Genomics, University of Cologne, Cologne, Germany
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            name:GeorgiaTech and Emory University
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               name:Department of Biomedical Engineering, GeorgiaTech and Emory University, Atlanta, USA
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            name:University Children’s Hospital of Cologne
            address:
               name:Department of Pediatric Oncology and Hematology, University Children’s Hospital of Cologne, Cologne, Germany
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            type:Organization
            name:University of Cologne, Center for Molecular Medicine (CMMC), Medical Faculty
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               name:University of Cologne, Center for Molecular Medicine (CMMC), Medical Faculty, Cologne, Germany
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            name:University Children’s Hospital of Cologne
            address:
               name:Department of Pediatric Oncology and Hematology, University Children’s Hospital of Cologne, Cologne, Germany
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      name:Susan Shao
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            name:SAS Institute Inc.
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               name:SAS Institute Inc., Cary, USA
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      name:Jie Shen
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            name:National Center for Toxicological Research, U.S. Food and Drug Administration
            address:
               name:National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, USA
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            name:University Children’s Hospital of Cologne
            address:
               name:Department of Pediatric Oncology and Hematology, University Children’s Hospital of Cologne, Cologne, Germany
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      name:Jo Vandesompele
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            name:Ghent University, Center for Medical Genetics, Ghent University
            address:
               name:Department of Pediatrics and Genetics, Ghent University, Center for Medical Genetics, Ghent University, Ghent, Belgium
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      name:Po-Yen Wu
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            name:Georgia Institute of Technology, School of Electrical and Computer Engineering
            address:
               name:Georgia Institute of Technology, School of Electrical and Computer Engineering, Atlanta, USA
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               name:Harvard Medical School, Massachusetts General Hospital, Boston, USA
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            name:National Center for Toxicological Research, U.S. Food and Drug Administration
            address:
               name:National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, USA
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               name:Stanford University, Stanford Genome Technology Center, Palo Alto, USA
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      name:Jiekun Xuan
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            name:National Center for Toxicological Research, U.S. Food and Drug Administration
            address:
               name:National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, USA
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            type:Organization
      name:Yong Yang
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            name:Eli Lilly and Company Research Informatics, Lilly Corporate Center
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               name:Eli Lilly and Company Research Informatics, Lilly Corporate Center, Indianapolis, USA
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            name:Marshfield Clinic Research Foundation, Biomedical Informatics Research Center
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               name:Marshfield Clinic Research Foundation, Biomedical Informatics Research Center, Marshfield, USA
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            name:BGI-Shenzhen, Main Building, Bei Shan Industrial Zone
            address:
               name:BGI-Shenzhen, Main Building, Bei Shan Industrial Zone, Shenzhen, China
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      name:Ke K. Zhang
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            name:University of North Dakota School of Medicine
            address:
               name:Department of Pathology, University of North Dakota School of Medicine, Grand Forks, USA
               type:PostalAddress
            type:Organization
      name:Ye Yin
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            name:BGI-Shenzhen, Main Building, Bei Shan Industrial Zone
            address:
               name:BGI-Shenzhen, Main Building, Bei Shan Industrial Zone, Shenzhen, China
               type:PostalAddress
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      name:Chen Zhao
      affiliation:
            name:Fudan University
            address:
               name:Collaborative Innovation Center for Genetics and Development, State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences and School of Pharmacy, Fudan University, Shanghai, China
               type:PostalAddress
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      name:Yuanting Zheng
      affiliation:
            name:Fudan University
            address:
               name:Collaborative Innovation Center for Genetics and Development, State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences and School of Pharmacy, Fudan University, Shanghai, China
               type:PostalAddress
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      name:Russell D. Wolfinger
      affiliation:
            name:SAS Institute Inc.
            address:
               name:SAS Institute Inc., Cary, USA
               type:PostalAddress
            type:Organization
      name:Tieliu Shi
      affiliation:
            name:East China Normal University, Center for Bioinformatics and Computational Biology, Shanghai Key Laboratory of Regulatory Biology, the Institute of Biomedical Sciences and School of Life Sciences
            address:
               name:East China Normal University, Center for Bioinformatics and Computational Biology, Shanghai Key Laboratory of Regulatory Biology, the Institute of Biomedical Sciences and School of Life Sciences, Shanghai, China
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            type:Organization
      name:Linda H. Malkas
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            name:Beckman Research Institute, City of Hope Comprehensive Cancer Center
            address:
               name:Department of Molecular & Cellular Biology, Beckman Research Institute, City of Hope Comprehensive Cancer Center, Duarte, USA
               type:PostalAddress
            type:Organization
      name:Frank Berthold
      affiliation:
            name:University Children’s Hospital of Cologne
            address:
               name:Department of Pediatric Oncology and Hematology, University Children’s Hospital of Cologne, Cologne, Germany
               type:PostalAddress
            type:Organization
            name:University of Cologne, Center for Molecular Medicine (CMMC), Medical Faculty
            address:
               name:University of Cologne, Center for Molecular Medicine (CMMC), Medical Faculty, Cologne, Germany
               type:PostalAddress
            type:Organization
      name:Jun Wang
      affiliation:
            name:BGI-Shenzhen, Main Building, Bei Shan Industrial Zone
            address:
               name:BGI-Shenzhen, Main Building, Bei Shan Industrial Zone, Shenzhen, China
               type:PostalAddress
            type:Organization
            name:University of Copenhagen
            address:
               name:Department of Biology, University of Copenhagen, Copenhagen, Denmark
               type:PostalAddress
            type:Organization
            name:King Abdulaziz University
            address:
               name:King Abdulaziz University, Jeddah, Saudi Arabia
               type:PostalAddress
            type:Organization
            name:University of Copenhagen
            address:
               name:Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark
               type:PostalAddress
            type:Organization
      name:Weida Tong
      affiliation:
            name:National Center for Toxicological Research, U.S. Food and Drug Administration
            address:
               name:National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, USA
               type:PostalAddress
            type:Organization
      name:Leming Shi
      affiliation:
            name:Fudan University
            address:
               name:Collaborative Innovation Center for Genetics and Development, State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences and School of Pharmacy, Fudan University, Shanghai, China
               type:PostalAddress
            type:Organization
            name:National Center for Toxicological Research, U.S. Food and Drug Administration
            address:
               name:National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Zhiyu Peng
      affiliation:
            name:BGI-Shenzhen, Main Building, Bei Shan Industrial Zone
            address:
               name:BGI-Shenzhen, Main Building, Bei Shan Industrial Zone, Shenzhen, China
               type:PostalAddress
            type:Organization
            name:BGI-Guangzhou, Guangzhou Higher Education Mega Center
            address:
               name:BGI-Guangzhou, Guangzhou Higher Education Mega Center, Guangzhou, China
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Matthias Fischer
      affiliation:
            name:University Children’s Hospital of Cologne
            address:
               name:Department of Pediatric Oncology and Hematology, University Children’s Hospital of Cologne, Cologne, Germany
               type:PostalAddress
            type:Organization
            name:University of Cologne, Center for Molecular Medicine (CMMC), Medical Faculty
            address:
               name:University of Cologne, Center for Molecular Medicine (CMMC), Medical Faculty, Cologne, Germany
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:BGI-Shenzhen, Main Building, Bei Shan Industrial Zone, Shenzhen, China
      name:Collaborative Innovation Center for Genetics and Development, State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences and School of Pharmacy, Fudan University, Shanghai, China
      name:Department of Pediatric Oncology and Hematology, University Children’s Hospital of Cologne, Cologne, Germany
      name:University of Cologne, Center for Molecular Medicine (CMMC), Medical Faculty, Cologne, Germany
      name:NIH/NCBI, Bethesda, USA
      name:BGI-Shenzhen, Main Building, Bei Shan Industrial Zone, Shenzhen, China
      name:NIH/NCBI, Bethesda, USA
      name:Eli Lilly and Company Research Informatics, Lilly Corporate Center, Indianapolis, USA
      name:Fondazione Bruno Kessler (FBK), Trento Povo, Italy
      name:AbbVie Inc., Global Pharmaceutical R&D, Souderton, USA
      name:GlaxoSmithKline, Discovery Analytics, Collegeville, USA
      name:Department of Internal Medicine, Rush University Cancer Center, Chicago, USA
      name:Department of Pediatric Oncology and Hematology, University Children’s Hospital of Cologne, Cologne, Germany
      name:National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, USA
      name:Collaborative Innovation Center for Genetics and Development, State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences and School of Pharmacy, Fudan University, Shanghai, China
      name:SAS Institute Inc., Cary, USA
      name:Marshfield Clinic Research Foundation, Biomedical Informatics Research Center, Marshfield, USA
      name:Thomson Reuters IP & Science, Carlsbad, USA
      name:Department of Pediatric Oncology and Hematology, University Children’s Hospital of Cologne, Cologne, Germany
      name:Collaborative Innovation Center for Genetics and Development, State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences and School of Pharmacy, Fudan University, Shanghai, China
      name:National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, USA
      name:Department of Pediatric Oncology and Hematology, University Children’s Hospital of Cologne, Cologne, Germany
      name:Center for Genomics and Division of Microbiology & Molecular Genetics, School of Medicine, Loma Linda University, Loma Linda, USA
      name:Department of Biomedical Engineering, GeorgiaTech and Emory University, Atlanta, USA
      name:Department of Internal Medicine, Rush University Cancer Center, Chicago, USA
      name:Fondazione Edmund Mach, CRI-CBC, San Michele all’Adige, Italy
      name:Children’s Hospital Los Angeles, Los Angeles, USA
      name:Department of Pediatric Hematology-Oncology, Molecular Oncology, Felsenstein Medical Research Center, Schneider Children’s Medical Center of Israel, Petach Tikva, Israel
      name:SAS Institute Inc., Cary, USA
      name:Thomson Reuters IP & Science, Carlsbad, USA
      name:Marshfield Clinic Research Foundation, Center of Human Genetics, Marshfield, USA
      name:Department of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany
      name:Fondazione Bruno Kessler (FBK), Trento Povo, Italy
      name:SAS Institute Inc., Cary, USA
      name:BGI-Shenzhen, Main Building, Bei Shan Industrial Zone, Shenzhen, China
      name:University of Nottingham, Children’s Brain Tumour Research Centre, Queen’s Medical Centre, University of Nottingham, Nottingham, UK
      name:Marshfield Clinic Research Foundation, Biomedical Informatics Research Center, Marshfield, USA
      name:Marshfield Clinic Research Foundation, Center of Human Genetics, Marshfield, USA
      name:Department of Internal Medicine, Rush University Cancer Center, Chicago, USA
      name:Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, WOC1 RM400S, HFM-210, Rockville, USA
      name:Thomson Reuters IP & Science, Carlsbad, USA
      name:Department of Internal Medicine, Rush University Cancer Center, Chicago, USA
      name:AbbVie Inc., Global Pharmaceutical Research and Development, North Chicago, USA
      name:National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, USA
      name:University of Arkansas at Little Rock, UALR/UAMS Joint Bioinformatics Graduate Program, Little Rock, USA
      name:Eli Lilly and Company, Discovery Statistics, Lilly Corporate Center, Indianapolis, USA
      name:National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, USA
      name:Department of Pathology, University of Valencia, Medical School, Valencia, Spain
      name:University of Cologne, Center for Molecular Medicine (CMMC), Medical Faculty, Cologne, Germany
      name:Department of Translational Genomics, University of Cologne, Cologne, Germany
      name:Department of Biomedical Engineering, GeorgiaTech and Emory University, Atlanta, USA
      name:Department of Pediatric Oncology and Hematology, University Children’s Hospital of Cologne, Cologne, Germany
      name:University of Cologne, Center for Molecular Medicine (CMMC), Medical Faculty, Cologne, Germany
      name:Department of Pediatric Oncology and Hematology, University Children’s Hospital of Cologne, Cologne, Germany
      name:SAS Institute Inc., Cary, USA
      name:National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, USA
      name:Department of Pediatric Oncology and Hematology, University Children’s Hospital of Cologne, Cologne, Germany
      name:Neuroblastoma Laboratory, Onco/Hematology Laboratory, SDB Department, University of Padua, Pediatric Research Institute, Padua, Italy
      name:Department of Pediatrics and Genetics, Ghent University, Center for Medical Genetics, Ghent University, Ghent, Belgium
      name:Georgia Institute of Technology, School of Electrical and Computer Engineering, Atlanta, USA
      name:Harvard Medical School, Massachusetts General Hospital, Boston, USA
      name:National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, USA
      name:Stanford University, Stanford Genome Technology Center, Palo Alto, USA
      name:National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, USA
      name:Eli Lilly and Company Research Informatics, Lilly Corporate Center, Indianapolis, USA
      name:Marshfield Clinic Research Foundation, Biomedical Informatics Research Center, Marshfield, USA
      name:BGI-Shenzhen, Main Building, Bei Shan Industrial Zone, Shenzhen, China
      name:Department of Pathology, University of North Dakota School of Medicine, Grand Forks, USA
      name:BGI-Shenzhen, Main Building, Bei Shan Industrial Zone, Shenzhen, China
      name:Collaborative Innovation Center for Genetics and Development, State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences and School of Pharmacy, Fudan University, Shanghai, China
      name:Collaborative Innovation Center for Genetics and Development, State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences and School of Pharmacy, Fudan University, Shanghai, China
      name:SAS Institute Inc., Cary, USA
      name:East China Normal University, Center for Bioinformatics and Computational Biology, Shanghai Key Laboratory of Regulatory Biology, the Institute of Biomedical Sciences and School of Life Sciences, Shanghai, China
      name:Department of Molecular & Cellular Biology, Beckman Research Institute, City of Hope Comprehensive Cancer Center, Duarte, USA
      name:Department of Pediatric Oncology and Hematology, University Children’s Hospital of Cologne, Cologne, Germany
      name:University of Cologne, Center for Molecular Medicine (CMMC), Medical Faculty, Cologne, Germany
      name:BGI-Shenzhen, Main Building, Bei Shan Industrial Zone, Shenzhen, China
      name:Department of Biology, University of Copenhagen, Copenhagen, Denmark
      name:King Abdulaziz University, Jeddah, Saudi Arabia
      name:Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark
      name:National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, USA
      name:Collaborative Innovation Center for Genetics and Development, State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences and School of Pharmacy, Fudan University, Shanghai, China
      name:National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, USA
      name:BGI-Shenzhen, Main Building, Bei Shan Industrial Zone, Shenzhen, China
      name:BGI-Guangzhou, Guangzhou Higher Education Mega Center, Guangzhou, China
      name:Department of Pediatric Oncology and Hematology, University Children’s Hospital of Cologne, Cologne, Germany
      name:University of Cologne, Center for Molecular Medicine (CMMC), Medical Faculty, Cologne, Germany

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• Check the income stats for https://www.springernature.com/

Analytics and Tracking {📊}

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Libraries {📚}

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