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LINK . SPRINGER . COM {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Link.springer.com Make Money
  6. Keywords
  7. Topics
  8. Questions
  9. Schema
  10. External Links
  11. Analytics And Tracking
  12. Libraries
  13. CDN Services

We are analyzing https://link.springer.com/article/10.1186/s13046-019-1266-0.

Title:
Advances in cancer immunotherapy 2019 – latest trends | Journal of Experimental & Clinical Cancer Research
Description:
Immunotherapy has become an established pillar of cancer treatment improving the prognosis of many patients with a broad variety of hematological and solid malignancies. The two main drivers behind this success are checkpoint inhibitors (CPIs) and chimeric antigen receptor (CAR) T cells. This review summarizes seminal findings from clinical and translational studies recently presented or published at important meetings or in top-tier journals, respectively. For checkpoint blockade, current studies focus on combinational approaches, perioperative use, new tumor entities, response prediction, toxicity management and use in special patient populations. Regarding cellular immunotherapy, recent studies confirmed safety and efficacy of CAR T cells in larger cohorts of patients with acute lymphoblastic leukemia or diffuse large B cell lymphoma. Different strategies to translate the striking success of CAR T cells in B cell malignancies to other hematological and solid cancer types are currently under clinical investigation. Regarding the regional distribution of registered clinical immunotherapy trials a shift from PD-1 / PD-L1 trials (mainly performed in the US and Europe) to CAR T cell trials (majority of trials performed in the US and China) can be noted.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

  • Health & Fitness
  • Education
  • Science

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

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How Does Link.springer.com Make Money? {💸}

We see no obvious way the site makes money.

Websites don't always need to be profitable; some serve as platforms for education or personal expression. Websites can serve multiple purposes. And this might be one of them. Link.springer.com has a revenue plan, but it's either invisible or we haven't found it.

Keywords {🔍}

pubmed, cancer, patients, google, scholar, article, cell, tumor, cas, cells, clinical, car, central, therapy, response, blockade, immunotherapy, pdl, treatment, trials, nivolumab, efficacy, studies, checkpoint, trial, med, oncol, receptor, chemotherapy, immune, lung, data, combination, study, phase, iii, results, mutational, melanoma, radiotherapy, effects, survival, ipilimumab, burden, antigen, cpi, solid, entities, safety, nsclc,

Topics {✒️}

von bergwelt-baildon inducing t-cell apoptosis sentinel-node-based adoptive immunotherapy modulate car-t-cell function �programmed death ligand” 12-month recurrence-free survival b-cell lymphoblastic leukemia pre-existing autoimmune diseases small-cell lung cancer small-cell lung cancer immune-related adverse events �tumor-agnostic” indication based determining pd-l1 expression tumoral pd-l1 expression pre-clinical evidence highlights clinical immuno-oncology landscape immune-mediated side effects nobel prize-worthy pursuit pre-existing autoimmune disease triple-negative breast cancer pd-1 / pd-l1-trials high-risk subset analysis cell-dependent antitumor immunity pd-1 / pd-l1-blockade pd-1/pd-l1 blockade potent anti-cd19 car article download pdf tumour burden ratio car t-related toxicities fda-approved diagnostic test immunogenic cell death systemic anti-tumor response sentinel node lymphocytes high therapeutic potential stage iii-iv melanoma retains immunosuppressive activity inflammatory tmb-signatures determined renal cell carcinoma recurrence-free survival making peri-operative usage deficient mismatch repair small hiv-positive cohort pancreatic ductal adenocarcinoma circulating tumor dna privacy choices/manage cookies tumor mutational burden cytotoxic t-lymphocyte phase iii trial baseline tumor size pre-existing autoimmune

Questions {❓}

  • Is PD-L1 expression a biomarker of response?
  • Recently reported studies on cellular therapy mainly addressed two important questions: (I) Long term and “real world” experience regarding toxicity and efficacy of CAR T cells (II) Can the striking success of CAR T cells in ALL and DLBCL be translated to other hematological and – more importantly - solid malignancies?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Advances in cancer immunotherapy 2019 – latest trends
         description:Immunotherapy has become an established pillar of cancer treatment improving the prognosis of many patients with a broad variety of hematological and solid malignancies. The two main drivers behind this success are checkpoint inhibitors (CPIs) and chimeric antigen receptor (CAR) T cells. This review summarizes seminal findings from clinical and translational studies recently presented or published at important meetings or in top-tier journals, respectively. For checkpoint blockade, current studies focus on combinational approaches, perioperative use, new tumor entities, response prediction, toxicity management and use in special patient populations. Regarding cellular immunotherapy, recent studies confirmed safety and efficacy of CAR T cells in larger cohorts of patients with acute lymphoblastic leukemia or diffuse large B cell lymphoma. Different strategies to translate the striking success of CAR T cells in B cell malignancies to other hematological and solid cancer types are currently under clinical investigation. Regarding the regional distribution of registered clinical immunotherapy trials a shift from PD-1 / PD-L1 trials (mainly performed in the US and Europe) to CAR T cell trials (majority of trials performed in the US and China) can be noted.
         datePublished:2019-06-19T00:00:00Z
         dateModified:2019-06-19T00:00:00Z
         pageStart:1
         pageEnd:11
         license:http://creativecommons.org/publicdomain/zero/1.0/
         sameAs:https://doi.org/10.1186/s13046-019-1266-0
         keywords:
            Immunotherapy
            Programmed cell death protein 1 (PD-1)
            Programmed cell death protein ligand 1 (PD-L1)
            Chimeric antigen receptor T cells (CAR T cells)
            Trends
            Regional distribution
            Cancer Research
            Immunology
            Apoptosis
            Oncology
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                        name:Institute of Pathology, LMU Munich, Munich, Germany
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               name:Gesa Schuebbe
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                     address:
                        name:Department of Medicine III, University Hospital Munich, LMU Munich, Munich, Germany
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                        name:Department of Medicine III, University Hospital Munich, LMU Munich, Munich, Germany
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                        name:German Cancer Consortium (DKTK), Partner Site Munich; and German Cancer Research Center (DKFZ), Heidelberg, Germany
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                        name:Department of Medicine III, University Hospital Munich, LMU Munich, Munich, Germany
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ScholarlyArticle:
      headline:Advances in cancer immunotherapy 2019 – latest trends
      description:Immunotherapy has become an established pillar of cancer treatment improving the prognosis of many patients with a broad variety of hematological and solid malignancies. The two main drivers behind this success are checkpoint inhibitors (CPIs) and chimeric antigen receptor (CAR) T cells. This review summarizes seminal findings from clinical and translational studies recently presented or published at important meetings or in top-tier journals, respectively. For checkpoint blockade, current studies focus on combinational approaches, perioperative use, new tumor entities, response prediction, toxicity management and use in special patient populations. Regarding cellular immunotherapy, recent studies confirmed safety and efficacy of CAR T cells in larger cohorts of patients with acute lymphoblastic leukemia or diffuse large B cell lymphoma. Different strategies to translate the striking success of CAR T cells in B cell malignancies to other hematological and solid cancer types are currently under clinical investigation. Regarding the regional distribution of registered clinical immunotherapy trials a shift from PD-1 / PD-L1 trials (mainly performed in the US and Europe) to CAR T cell trials (majority of trials performed in the US and China) can be noted.
      datePublished:2019-06-19T00:00:00Z
      dateModified:2019-06-19T00:00:00Z
      pageStart:1
      pageEnd:11
      license:http://creativecommons.org/publicdomain/zero/1.0/
      sameAs:https://doi.org/10.1186/s13046-019-1266-0
      keywords:
         Immunotherapy
         Programmed cell death protein 1 (PD-1)
         Programmed cell death protein ligand 1 (PD-L1)
         Chimeric antigen receptor T cells (CAR T cells)
         Trends
         Regional distribution
         Cancer Research
         Immunology
         Apoptosis
         Oncology
      image:
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      isPartOf:
         name:Journal of Experimental & Clinical Cancer Research
         issn:
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         volumeNumber:38
         type:
            Periodical
            PublicationVolume
      publisher:
         name:BioMed Central
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Stephan Kruger
            affiliation:
                  name:University Hospital Munich, LMU Munich
                  address:
                     name:Department of Medicine III, University Hospital Munich, LMU Munich, Munich, Germany
                     type:PostalAddress
                  type:Organization
                  name:University Hospital, LMU Munich
                  address:
                     name:Center of Integrated Protein Science Munich (CIPS-M) and Division of Clinical Pharmacology, Department of Medicine IV, University Hospital, LMU Munich, Munich, Germany
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Matthias Ilmer
            affiliation:
                  name:University Hospital, LMU Munich
                  address:
                     name:Department of General, Visceral, and Transplantation Surgery, University Hospital, LMU Munich, Munich, Germany
                     type:PostalAddress
                  type:Organization
                  name:German Cancer Consortium (DKTK), Partner Site Munich; and German Cancer Research Center (DKFZ)
                  address:
                     name:German Cancer Consortium (DKTK), Partner Site Munich; and German Cancer Research Center (DKFZ), Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Sebastian Kobold
            affiliation:
                  name:University Hospital, LMU Munich
                  address:
                     name:Center of Integrated Protein Science Munich (CIPS-M) and Division of Clinical Pharmacology, Department of Medicine IV, University Hospital, LMU Munich, Munich, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Bruno L. Cadilha
            affiliation:
                  name:University Hospital, LMU Munich
                  address:
                     name:Center of Integrated Protein Science Munich (CIPS-M) and Division of Clinical Pharmacology, Department of Medicine IV, University Hospital, LMU Munich, Munich, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Stefan Endres
            affiliation:
                  name:University Hospital, LMU Munich
                  address:
                     name:Center of Integrated Protein Science Munich (CIPS-M) and Division of Clinical Pharmacology, Department of Medicine IV, University Hospital, LMU Munich, Munich, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Steffen Ormanns
            affiliation:
                  name:Institute of Pathology, LMU Munich
                  address:
                     name:Institute of Pathology, LMU Munich, Munich, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Gesa Schuebbe
            affiliation:
                  name:University Hospital Munich, LMU Munich
                  address:
                     name:Department of Medicine III, University Hospital Munich, LMU Munich, Munich, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Bernhard W. Renz
            affiliation:
                  name:University Hospital, LMU Munich
                  address:
                     name:Department of General, Visceral, and Transplantation Surgery, University Hospital, LMU Munich, Munich, Germany
                     type:PostalAddress
                  type:Organization
                  name:German Cancer Consortium (DKTK), Partner Site Munich; and German Cancer Research Center (DKFZ)
                  address:
                     name:German Cancer Consortium (DKTK), Partner Site Munich; and German Cancer Research Center (DKFZ), Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jan G. D’Haese
            affiliation:
                  name:University Hospital, LMU Munich
                  address:
                     name:Department of General, Visceral, and Transplantation Surgery, University Hospital, LMU Munich, Munich, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Hans Schloesser
            affiliation:
                  name:University Hospital of Cologne
                  address:
                     name:University Hospital of Cologne, Cologne, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Volker Heinemann
            affiliation:
                  name:University Hospital Munich, LMU Munich
                  address:
                     name:Department of Medicine III, University Hospital Munich, LMU Munich, Munich, Germany
                     type:PostalAddress
                  type:Organization
                  name:German Cancer Consortium (DKTK), Partner Site Munich; and German Cancer Research Center (DKFZ)
                  address:
                     name:German Cancer Consortium (DKTK), Partner Site Munich; and German Cancer Research Center (DKFZ), Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Marion Subklewe
            affiliation:
                  name:University Hospital Munich, LMU Munich
                  address:
                     name:Department of Medicine III, University Hospital Munich, LMU Munich, Munich, Germany
                     type:PostalAddress
                  type:Organization
                  name:German Cancer Consortium (DKTK), Partner Site Munich; and German Cancer Research Center (DKFZ)
                  address:
                     name:German Cancer Consortium (DKTK), Partner Site Munich; and German Cancer Research Center (DKFZ), Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
                  name:Gene Center LMU
                  address:
                     name:Gene Center LMU, Munich, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Stefan Boeck
            affiliation:
                  name:University Hospital Munich, LMU Munich
                  address:
                     name:Department of Medicine III, University Hospital Munich, LMU Munich, Munich, Germany
                     type:PostalAddress
                  type:Organization
                  name:German Cancer Consortium (DKTK), Partner Site Munich; and German Cancer Research Center (DKFZ)
                  address:
                     name:German Cancer Consortium (DKTK), Partner Site Munich; and German Cancer Research Center (DKFZ), Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jens Werner
            affiliation:
                  name:University Hospital, LMU Munich
                  address:
                     name:Department of General, Visceral, and Transplantation Surgery, University Hospital, LMU Munich, Munich, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Michael von Bergwelt-Baildon
            affiliation:
                  name:University Hospital Munich, LMU Munich
                  address:
                     name:Department of Medicine III, University Hospital Munich, LMU Munich, Munich, Germany
                     type:PostalAddress
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                  name:German Cancer Consortium (DKTK), Partner Site Munich; and German Cancer Research Center (DKFZ)
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                     name:German Cancer Consortium (DKTK), Partner Site Munich; and German Cancer Research Center (DKFZ), Heidelberg, Germany
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                  name:Center for Molecular Medicine Cologne (CMMC)
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                     name:Center for Molecular Medicine Cologne (CMMC), Cologne, Germany
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                  name:Gene Center LMU
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      name:University Hospital Munich, LMU Munich
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         name:Department of Medicine III, University Hospital Munich, LMU Munich, Munich, Germany
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         name:Center of Integrated Protein Science Munich (CIPS-M) and Division of Clinical Pharmacology, Department of Medicine IV, University Hospital, LMU Munich, Munich, Germany
         type:PostalAddress
      name:University Hospital, LMU Munich
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         name:Department of General, Visceral, and Transplantation Surgery, University Hospital, LMU Munich, Munich, Germany
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         name:German Cancer Consortium (DKTK), Partner Site Munich; and German Cancer Research Center (DKFZ), Heidelberg, Germany
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         name:Center of Integrated Protein Science Munich (CIPS-M) and Division of Clinical Pharmacology, Department of Medicine IV, University Hospital, LMU Munich, Munich, Germany
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         name:Institute of Pathology, LMU Munich, Munich, Germany
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         name:Department of Medicine III, University Hospital Munich, LMU Munich, Munich, Germany
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         name:Department of General, Visceral, and Transplantation Surgery, University Hospital, LMU Munich, Munich, Germany
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