We are analyzing https://link.springer.com/article/10.1186/s13045-020-00990-3.

Title:
Targeting the Wnt/β-catenin signaling pathway in cancer | Journal of Hematology & Oncology
Description:
The aberrant Wnt/β-catenin signaling pathway facilitates cancer stem cell renewal, cell proliferation and differentiation, thus exerting crucial roles in tumorigenesis and therapy response. Accumulated investigations highlight the therapeutic potential of agents targeting Wnt/β-catenin signaling in cancer. Wnt ligand/ receptor interface, β-catenin destruction complex and TCF/β-catenin transcription complex are key components of the cascade and have been targeted with interventions in preclinical and clinical evaluations. This scoping review aims at outlining the latest progress on the current approaches and perspectives of Wnt/β-catenin signaling pathway targeted therapy in various cancer types. Better understanding of the updates on the inhibitors, antagonists and activators of Wnt/β-catenin pathway rationalizes innovative strategies for personalized cancer treatment. Further investigations are warranted to confirm precise and secure targeted agents and achieve optimal use with clinical benefits in malignant diseases.
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28 years and 1 months (reg. 1997-05-29).

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Keywords {🔍}

pubmed, cancer, article, google, scholar, cas, signaling, wnt, pathway, wntβcatenin, cells, cell, central, zhang, stem, βcatenin, targeting, wang, growth, inhibitor, colorectal, inhibition, targeted, inhibitors, res, therapy, tumor, breast, complex, treatment, inhibits, agents, chen, tankyrase, apoptosis, fzd, lung, oncol, shandong, clinical, activation, carcinoma, expression, differentiation, wntbetacatenin, colon, target, canonical, patients, med,

Topics {✒️}

wnt/β-catenin targeted therapies mir-126-5p/beta-catenin/cbp signaling akt/β-catenin-driven hepatocellular carcinoma multi-targeted proliferation-linked signaling β-catenin-dependent signaling pathway wnt/beta-catenin signaling pathway wnt/β-catenin targeted agents attenuates wnt/beta-catenin signaling wnt/β-catenin pathway interacted wnt/β-catenin signaling pathway inhibit wnt/β-catenin signaling inhibit wnt/β-catenin pathway wnt/β-catenin cascade contributed beta-catenin/tcf/lef functions inhibited wnt/β-catenin pathway targeting wnt/beta-catenin pathway regulate wnt/β-catenin signaling tcf/β-catenin transcription complex inactivating wnt/β-catenin signaling β-catenin/tcf4 interaction blocks hyperactivated cbp/β-catenin signaling activating wnt/β-catenin signaling β-catenin/tcf-target genes targeting β-catenin-tcf4 interaction suppress wnt/β-catenin signaling wnt protein-mediated signaling tcf/lef target gene β-catenin targeted genes transcription factor β-catenin wnt/beta-catenin signaling wnt/beta-catenin pathway wnt/β-catenin signalling wnt/β-catenin signaling [21 wnt/β-catenin signaling wnt/β-catenin signaling [106] wnt/β-catenin signaling [132] wnt/β-catenin pathway /lymphoid enhancer-binding factor β-catenin-dependent transcription β-catenin/tcf complex targeting wnt/beta-catenin β-catenin destruction complex showed anti-tumor properties stabilized β-catenin translocates hepatocyte growth factor/met response element-binding protein axin/β-catenin interaction [159] tcf/lef transcription factors k-ras-mutated colorectal cancer decreasing β-catenin levels

Questions {❓}

Can we safely target the WNT pathway?
Is beta-catenin a druggable target for cancer therapy?
Targeting Wnt signaling: can we safely eradicate cancer stem cells?

Schema {🗺️}

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         description:The aberrant Wnt/β-catenin signaling pathway facilitates cancer stem cell renewal, cell proliferation and differentiation, thus exerting crucial roles in tumorigenesis and therapy response. Accumulated investigations highlight the therapeutic potential of agents targeting Wnt/β-catenin signaling in cancer. Wnt ligand/ receptor interface, β-catenin destruction complex and TCF/β-catenin transcription complex are key components of the cascade and have been targeted with interventions in preclinical and clinical evaluations. This scoping review aims at outlining the latest progress on the current approaches and perspectives of Wnt/β-catenin signaling pathway targeted therapy in various cancer types. Better understanding of the updates on the inhibitors, antagonists and activators of Wnt/β-catenin pathway rationalizes innovative strategies for personalized cancer treatment. Further investigations are warranted to confirm precise and secure targeted agents and achieve optimal use with clinical benefits in malignant diseases.
         datePublished:2020-12-04T00:00:00Z
         dateModified:2020-12-04T00:00:00Z
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            Cancer
            Targeted therapy
            Cancer stem cell
            Oncology
            Hematology
            Cancer Research
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ScholarlyArticle:
      headline:Targeting the Wnt/β-catenin signaling pathway in cancer
      description:The aberrant Wnt/β-catenin signaling pathway facilitates cancer stem cell renewal, cell proliferation and differentiation, thus exerting crucial roles in tumorigenesis and therapy response. Accumulated investigations highlight the therapeutic potential of agents targeting Wnt/β-catenin signaling in cancer. Wnt ligand/ receptor interface, β-catenin destruction complex and TCF/β-catenin transcription complex are key components of the cascade and have been targeted with interventions in preclinical and clinical evaluations. This scoping review aims at outlining the latest progress on the current approaches and perspectives of Wnt/β-catenin signaling pathway targeted therapy in various cancer types. Better understanding of the updates on the inhibitors, antagonists and activators of Wnt/β-catenin pathway rationalizes innovative strategies for personalized cancer treatment. Further investigations are warranted to confirm precise and secure targeted agents and achieve optimal use with clinical benefits in malignant diseases.
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         Wnt/β-catenin signaling pathway
         Cancer
         Targeted therapy
         Cancer stem cell
         Oncology
         Hematology
         Cancer Research
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PostalAddress:
      name:Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China
      name:Department of Hematology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China
      name:School of medicine, Shandong University, Jinan, China
      name:Shandong Provincial Engineering Research Center of Lymphoma, Jinan, China
      name:Branch of National Clinical Research Center for Hematologic Diseases, Jinan, China
      name:National Clinical Research Center for Hematologic Diseases, the First Affiliated Hospital of Soochow University, Suzhou, China
      name:Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China
      name:Department of Hematology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China
      name:School of medicine, Shandong University, Jinan, China
      name:Shandong Provincial Engineering Research Center of Lymphoma, Jinan, China
      name:Branch of National Clinical Research Center for Hematologic Diseases, Jinan, China
      name:National Clinical Research Center for Hematologic Diseases, the First Affiliated Hospital of Soochow University, Suzhou, China

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