We are analyzing https://link.springer.com/article/10.1186/s13045-019-0711-z.

Title:
Downregulation of RNF128 activates Wnt/β-catenin signaling to induce cellular EMT and stemness via CD44 and CTTN ubiquitination in melanoma | Journal of Hematology & Oncology
Description:
Background Ring finger proteins (RNFs) were involved in carcinogenesis. Here, we aimed to explore the detailed mechanism of RNF128 in the progression of melanoma. Methods We reanalyzed several gene expression profiles from the Gene Expression Omnibus (GEO) database and obtained the overlapped differential expressed RNF genes. Among them, RNF128 was selected to further explore its expression, the biological significance, and the underlying molecular mechanism, as well as the clinical relevance in melanoma patients. Results RNF128 was found to be significantly downregulated in the selected datasets, which was further verified in our melanoma tissues. Moreover, RNF128 downregulation was shown to correlate with the malignant phenotype of melanoma, and further functional assays demonstrated that low levels of RNF128 promoted melanoma progression via inducing cell epithelial-mesenchymal transition (EMT) and the acquisition of stemness. Mechanistically, RNF128 interference activated the Wnt pathway via simultaneously ubiquitinating CD44/cortactin (CTTN), resulting in CD44 and c-Myc transcription, thus revealed that RNF128 participated in a positive feedback of the Wnt pathway-CD44 loop. Clinically, we found that patients expressing low RNF128 and high CD44/CTTN levels had a poor prognosis. Conclusion Downregulated RNF128 activates Wnt signaling to induce cellular EMT and stemness by ubiquitinating and degrading CD44/CTTN, and RNF128 is a reliable diagnostic and prognostic biomarker, and a deeper understanding of RNF128 may contribute to the treatment of melanoma.
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Keywords {🔍}

rnf, cells, melanoma, expression, cttn, pubmed, cell, article, emt, fig, google, scholar, wnt, stemness, level, cas, low, levels, cancer, western, tissues, blot, signaling, found, assays, protein, additional, results, analysis, patients, performed, file, detect, progression, showed, invasion, downregulation, mshrnf, shanghai, ubiquitination, proteins, pathway, promotes, china, figure, central, wang, downregulated, qrtpcr, transfected,

Topics {✒️}

cmv-h_rnf128-egfp-3flag-pgk-puro lentiviral vectors plvx-shrna-egfp-pgk-puro lentiviral vectors plvx-shrna-egfp-pgk-puro activating cyclin d-cdk4/6-rb skin cancer-related deaths ras/stat5-regulated invasion receptor induce epithelial-mesenchymal transition topflash/fopflash reporter assay canonical wnt/β-catenin pathway jian-ying gu pgmlv-sc5-puromycin vectors wnt/β-catenin-cd44 loop wnt/β-catenin-cd44 signaling a2058-vector/a2058-rnf128 cells epithelial-mesenchymal transition beta-catenin-sensitive isoforms rnf128-wnt signaling-cd44 axis ring-type ubiquitin ligase article download pdf wnt/β-catenin signaling horseradish peroxidase-labeled igg histone post-translational modifications spasmolytic polypeptide-expressing metaplasia nf-κb-il-8 axis nf-kappab-il-8 axis wnt signaling-related molecules wnt/β-catenin pathway submaximal wnt signalling transmembrane ubiquitin-protein enzyme annexin v-apc/7-add wnt signaling-cd44 loop wnt signaling-cd44 axis a2058-vector cells expressed brafv600e-induced lung tumors n-terminal ubiquitination sites cell receptor-cd3 degradation jia-cheng lu wnt pathway-cd44 loop shrnf128-induced cell emt liver cancer institute shrnf128-induced cell invasion kaplan-meier analyses showing sds-page sample buffer tagged ubiquitin vectors m14-shnc/m14-shrnf128 a2058-vector cells presented c-myc transcription lymphoid enhancer factor-1 rnf128-induced cell emt rnf128-induced cell invasion

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         headline:Downregulation of RNF128 activates Wnt/β-catenin signaling to induce cellular EMT and stemness via CD44 and CTTN ubiquitination in melanoma
         description:Ring finger proteins (RNFs) were involved in carcinogenesis. Here, we aimed to explore the detailed mechanism of RNF128 in the progression of melanoma. We reanalyzed several gene expression profiles from the Gene Expression Omnibus (GEO) database and obtained the overlapped differential expressed RNF genes. Among them, RNF128 was selected to further explore its expression, the biological significance, and the underlying molecular mechanism, as well as the clinical relevance in melanoma patients. RNF128 was found to be significantly downregulated in the selected datasets, which was further verified in our melanoma tissues. Moreover, RNF128 downregulation was shown to correlate with the malignant phenotype of melanoma, and further functional assays demonstrated that low levels of RNF128 promoted melanoma progression via inducing cell epithelial-mesenchymal transition (EMT) and the acquisition of stemness. Mechanistically, RNF128 interference activated the Wnt pathway via simultaneously ubiquitinating CD44/cortactin (CTTN), resulting in CD44 and c-Myc transcription, thus revealed that RNF128 participated in a positive feedback of the Wnt pathway-CD44 loop. Clinically, we found that patients expressing low RNF128 and high CD44/CTTN levels had a poor prognosis. Downregulated RNF128 activates Wnt signaling to induce cellular EMT and stemness by ubiquitinating and degrading CD44/CTTN, and RNF128 is a reliable diagnostic and prognostic biomarker, and a deeper understanding of RNF128 may contribute to the treatment of melanoma.
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      headline:Downregulation of RNF128 activates Wnt/β-catenin signaling to induce cellular EMT and stemness via CD44 and CTTN ubiquitination in melanoma
      description:Ring finger proteins (RNFs) were involved in carcinogenesis. Here, we aimed to explore the detailed mechanism of RNF128 in the progression of melanoma. We reanalyzed several gene expression profiles from the Gene Expression Omnibus (GEO) database and obtained the overlapped differential expressed RNF genes. Among them, RNF128 was selected to further explore its expression, the biological significance, and the underlying molecular mechanism, as well as the clinical relevance in melanoma patients. RNF128 was found to be significantly downregulated in the selected datasets, which was further verified in our melanoma tissues. Moreover, RNF128 downregulation was shown to correlate with the malignant phenotype of melanoma, and further functional assays demonstrated that low levels of RNF128 promoted melanoma progression via inducing cell epithelial-mesenchymal transition (EMT) and the acquisition of stemness. Mechanistically, RNF128 interference activated the Wnt pathway via simultaneously ubiquitinating CD44/cortactin (CTTN), resulting in CD44 and c-Myc transcription, thus revealed that RNF128 participated in a positive feedback of the Wnt pathway-CD44 loop. Clinically, we found that patients expressing low RNF128 and high CD44/CTTN levels had a poor prognosis. Downregulated RNF128 activates Wnt signaling to induce cellular EMT and stemness by ubiquitinating and degrading CD44/CTTN, and RNF128 is a reliable diagnostic and prognostic biomarker, and a deeper understanding of RNF128 may contribute to the treatment of melanoma.
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      name:Department of Liver Surgery and Transplantation, Liver Cancer Institute and Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, People’s Republic of China
      name:Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, People’s Republic of China
      name:Department of Liver Surgery and Transplantation, Liver Cancer Institute and Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, People’s Republic of China
      name:Department of Plastic Surgery, Zhongshan Hospital, Fudan University, Shanghai, People’s Republic of China
      name:Department of Plastic Surgery, Zhongshan Hospital, Fudan University, Shanghai, People’s Republic of China
      name:Department of Plastic Surgery, Zhongshan Hospital, Fudan University, Shanghai, People’s Republic of China
      name:Department of Plastic Surgery, Zhongshan Hospital, Fudan University, Shanghai, People’s Republic of China
      name:Department of Plastic Surgery, Zhongshan Hospital, Fudan University, Shanghai, People’s Republic of China

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