We are analyzing https://link.springer.com/article/10.1186/s13045-015-0181-x.

Title:
Exosomes in cancer: small particle, big player | Journal of Hematology & Oncology
Description:
Exosomes have emerged as a novel mode of intercellular communication. Exosomes can shuttle bioactive molecules including proteins, DNA, mRNA, as well as non-coding RNAs from one cell to another, leading to the exchange of genetic information and reprogramming of the recipient cells. Increasing evidence suggests that tumor cells release excessive amount of exosomes, which may influence tumor initiation, growth, progression, metastasis, and drug resistance. In addition, exosomes transfer message from tumor cells to immune cells and stromal cells, contributing to the escape from immune surveillance and the formation of tumor niche. In this review, we highlight the recent advances in the biology of exosomes as cancer communicasomes. We review the multifaceted roles of exosomes, the small secreted particles, in communicating with other cells within tumor microenvironment. Given that exosomes are cell type specific, stable, and accessible from body fluids, exosomes may provide promising biomarkers for cancer diagnosis and represent new targets for cancer therapy.
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Keywords {🔍}

exosomes, pubmed, cells, cancer, google, scholar, cas, tumor, cell, central, exosome, exosomal, breast, stromal, zhang, proteins, transfer, progression, metastasis, tumorderived, human, growth, biomarkers, potential, function, drug, extracellular, release, uptake, cellderived, promote, prostate, metastatic, biol, resistance, therapy, secretion, endothelial, patients, formation, roles, nat, liu, vesicles, mirnas, induce, stem, micrornas, delivery, res,

Topics {✒️}

hui qian & wenrong xu adipose-derived stem cells bone marrow-derived cells castration-resistant prostate cancer tgf-beta/smad pathway macrophage-induced malignant invasion ebv-positive nasopharyngeal carcinoma autocrine wnt-pcp signaling myeloid-derived suppressor cells rna-induced silencing complex syndecan-syntenin-alix regulates ultra-sensitive liquid biopsy countering trastuzumab-based therapy transferring multidrug-resistant proteins pancreatic cancer-derived exosomes dendritic cell-derived exosomes exosome-mediated wnt signaling gap junction-mediated import establishing pre-metastatic niche cell type-dependent manner cd34+ blast-derived exosomes breast cancer-derived exosomes nasopharyngeal carcinoma-derived exosomes tumor cell-derived exosomes cancer cell-derived exosomes human tumor-derived exosomes cell-dependent antitumor effects tumor-derived exosomes promotes tumor-derived exosomes interfere utilizing tumor-derived exosomes unmodified tumor-derived exosomes targeting factor-inhibiting hif-1 transfer multi-drug resistance drive th17-mediated tumorigenesis prostate tumor-derived exosomes rab27-dependent exosome release orthotopic nude-mouse models bi-directional interaction network extracellular vesicle-mediated transfer pancreatic ductal adenocarcinoma mediate hypoxia-dependent activation neutralizing antibody-based drugs her2-overexpressing exosomes tumor-derived exosomes contribute specific mirna profile mesenchymal stromal cells tumour-promoting stromal myofibroblasts early-stage breast cancer plasma-derived exosomal survivin il-6/stat3 pathway [63]

Questions {❓}

Can urinary exosomes act as treatment response markers in prostate cancer?

Schema {🗺️}

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         description:Exosomes have emerged as a novel mode of intercellular communication. Exosomes can shuttle bioactive molecules including proteins, DNA, mRNA, as well as non-coding RNAs from one cell to another, leading to the exchange of genetic information and reprogramming of the recipient cells. Increasing evidence suggests that tumor cells release excessive amount of exosomes, which may influence tumor initiation, growth, progression, metastasis, and drug resistance. In addition, exosomes transfer message from tumor cells to immune cells and stromal cells, contributing to the escape from immune surveillance and the formation of tumor niche. In this review, we highlight the recent advances in the biology of exosomes as cancer communicasomes. We review the multifaceted roles of exosomes, the small secreted particles, in communicating with other cells within tumor microenvironment. Given that exosomes are cell type specific, stable, and accessible from body fluids, exosomes may provide promising biomarkers for cancer diagnosis and represent new targets for cancer therapy.
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      headline:Exosomes in cancer: small particle, big player
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