We are analyzing https://link.springer.com/article/10.1186/s13024-024-00740-w.

Title:
Astrocytic autophagy plasticity modulates Aβ clearance and cognitive function in Alzheimer’s disease | Molecular Neurodegeneration
Description:
Background Astrocytes, one of the most resilient cells in the brain, transform into reactive astrocytes in response to toxic proteins such as amyloid beta (Aβ) in Alzheimer’s disease (AD). However, reactive astrocyte-mediated non-cell autonomous neuropathological mechanism is not fully understood yet. We aimed our study to find out whether Aβ-induced proteotoxic stress affects the expression of autophagy genes and the modulation of autophagic flux in astrocytes, and if yes, how Aβ-induced autophagy-associated genes are involved Aβ clearance in astrocytes of animal model of AD. Methods Whole RNA sequencing (RNA-seq) was performed to detect gene expression patterns in Aβ-treated human astrocytes in a time-dependent manner. To verify the role of astrocytic autophagy in an AD mouse model, we developed AAVs expressing shRNAs for MAP1LC3B/LC3B (LC3B) and Sequestosome1 (SQSTM1) based on AAV-R-CREon vector, which is a Cre recombinase-dependent gene-silencing system. Also, the effect of astrocyte-specific overexpression of LC3B on the neuropathology in AD (APP/PS1) mice was determined. Neuropathological alterations of AD mice with astrocytic autophagy dysfunction were observed by confocal microscopy and transmission electron microscope (TEM). Behavioral changes of mice were examined through novel object recognition test (NOR) and novel object place recognition test (NOPR). Results Here, we show that astrocytes, unlike neurons, undergo plastic changes in autophagic processes to remove Aβ. Aβ transiently induces expression of LC3B gene and turns on a prolonged transcription of SQSTM1 gene. The Aβ-induced astrocytic autophagy accelerates urea cycle and putrescine degradation pathway. Pharmacological inhibition of autophagy exacerbates mitochondrial dysfunction and oxidative stress in astrocytes. Astrocyte-specific knockdown of LC3B and SQSTM1 significantly increases Aβ plaque formation and GFAP-positive astrocytes in APP/PS1 mice, along with a significant reduction of neuronal marker and cognitive function. In contrast, astrocyte-specific overexpression of LC3B reduced Aβ aggregates in the brain of APP/PS1 mice. An increase of LC3B and SQSTM1 protein is found in astrocytes of the hippocampus in AD patients. Conclusions Taken together, our data indicates that Aβ-induced astrocytic autophagic plasticity is an important cellular event to modulate Aβ clearance and maintain cognitive function in AD mice.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Science
Education
Health & Fitness

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We don’t know how the website earns money.

The purpose of some websites isn't monetary gain; they're meant to inform, educate, or foster collaboration. Everyone has unique reasons for building websites. This could be an example. Link.springer.com might be plotting its profit, but the way they're doing it isn't detectable yet.

Keywords {🔍}

astrocytes, autophagy, mice, lcb, usa, fig, cell, appps, pubmed, article, sqstm, astrocytic, google, scholar, astrocyte, brain, oligomer, reactive, disease, cells, human, gfap, cas, function, kim, shrna, data, korea, supplementary, expression, mouse, mitochondrial, analysis, significantly, group, autophagic, performed, primary, astrocytespecific, quantification, hippocampus, death, culture, alzheimers, number, lee, system, cycle, pathway, increased,

Topics {✒️}

aav-ef1a-dio-control shrna + aav-pgfap-cre aav- ef1a-dio-lc3b shrna + aav-pgfap-cre aav-ef1a-dio-lc3b shrna + aav-pgfap-cre aav-ef1a-dio-sqstm1 shrna + aav-pgfap-cre /products/e7530-nebnext-ultra-rna-library-prep-kit aav-pgfap-cre overexpression viruses nano-md uv-vis spectrophotometer cre-dependent shrna-expressing system app/ps1 + aav-gfap-lc3b-mcherry mao-b-mediated gaba/h2o2/ammonia liquid chromatography/mass spectrometry immpress-ap anti-rabbit igg toxin-mediated cell-death system lc3b shrna-expressing app/ps1 app/ps1 + aav-gfap-mcherry cell-type-specific rna interference driven cre-dependent manner rfp-gfp-lc3b-expressing astrocytes 1 mg/ml poly-d-lysine aav-pgfap overexpression system aav-loxp-active caspase 3 app/ps1 + aav-gfap-lc3b aav-r-creon vector app/ps1 + lc3b shrna mice aav-pgfap-cre aav-r-creon-lc3b aav-gfap-cre virus 3-methyl-butane ethyl ester article download pdf 11 c-deuterium-l-deprenyl generation high-throughput sequencer h-dependent oxidoreductase activity generate high-titer aav rfp-gfp-lc3 plasmid soluble beta-amyloid leads de novo formation double-membrane sequestered vesicle mitochondria-specific superoxide indicator quantitative real time-pcr app/ps1 + lc3b shrna anti-neuronal nuclear antigen central nervous system p0–p3 c57bl/6 mice cell titer-glo reagent app/ps1 + sqstm1 shrna wt + aav-gfap-mcherry consecutive freeze/thaw cycles aβ oligomer-induced elevation chaperone mediated autophagy anti-actb/β-actin

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Astrocytic autophagy plasticity modulates Aβ clearance and cognitive function in Alzheimer’s disease
         description:Astrocytes, one of the most resilient cells in the brain, transform into reactive astrocytes in response to toxic proteins such as amyloid beta (Aβ) in Alzheimer’s disease (AD). However, reactive astrocyte-mediated non-cell autonomous neuropathological mechanism is not fully understood yet. We aimed our study to find out whether Aβ-induced proteotoxic stress affects the expression of autophagy genes and the modulation of autophagic flux in astrocytes, and if yes, how Aβ-induced autophagy-associated genes are involved Aβ clearance in astrocytes of animal model of AD. Whole RNA sequencing (RNA-seq) was performed to detect gene expression patterns in Aβ-treated human astrocytes in a time-dependent manner. To verify the role of astrocytic autophagy in an AD mouse model, we developed AAVs expressing shRNAs for MAP1LC3B/LC3B (LC3B) and Sequestosome1 (SQSTM1) based on AAV-R-CREon vector, which is a Cre recombinase-dependent gene-silencing system. Also, the effect of astrocyte-specific overexpression of LC3B on the neuropathology in AD (APP/PS1) mice was determined. Neuropathological alterations of AD mice with astrocytic autophagy dysfunction were observed by confocal microscopy and transmission electron microscope (TEM). Behavioral changes of mice were examined through novel object recognition test (NOR) and novel object place recognition test (NOPR). Here, we show that astrocytes, unlike neurons, undergo plastic changes in autophagic processes to remove Aβ. Aβ transiently induces expression of LC3B gene and turns on a prolonged transcription of SQSTM1 gene. The Aβ-induced astrocytic autophagy accelerates urea cycle and putrescine degradation pathway. Pharmacological inhibition of autophagy exacerbates mitochondrial dysfunction and oxidative stress in astrocytes. Astrocyte-specific knockdown of LC3B and SQSTM1 significantly increases Aβ plaque formation and GFAP-positive astrocytes in APP/PS1 mice, along with a significant reduction of neuronal marker and cognitive function. In contrast, astrocyte-specific overexpression of LC3B reduced Aβ aggregates in the brain of APP/PS1 mice. An increase of LC3B and SQSTM1 protein is found in astrocytes of the hippocampus in AD patients. Taken together, our data indicates that Aβ-induced astrocytic autophagic plasticity is an important cellular event to modulate Aβ clearance and maintain cognitive function in AD mice.
         datePublished:2024-07-23T00:00:00Z
         dateModified:2024-07-23T00:00:00Z
         pageStart:1
         pageEnd:26
         license:http://creativecommons.org/publicdomain/zero/1.0/
         sameAs:https://doi.org/10.1186/s13024-024-00740-w
         keywords:
            Alzheimer’s disease
            Astrocytes
            Amyloid beta (Aβ)
            Autophagy
            Mitochondria
            Aβ clearance
            Neurosciences
            Neurology
            Molecular Medicine
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13024-024-00740-w/MediaObjects/13024_2024_740_Fig1_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13024-024-00740-w/MediaObjects/13024_2024_740_Fig2_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13024-024-00740-w/MediaObjects/13024_2024_740_Fig3_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13024-024-00740-w/MediaObjects/13024_2024_740_Fig4_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13024-024-00740-w/MediaObjects/13024_2024_740_Fig5_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13024-024-00740-w/MediaObjects/13024_2024_740_Fig6_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13024-024-00740-w/MediaObjects/13024_2024_740_Fig7_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13024-024-00740-w/MediaObjects/13024_2024_740_Fig8_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13024-024-00740-w/MediaObjects/13024_2024_740_Fig9_HTML.png
         isPartOf:
            name:Molecular Neurodegeneration
            issn:
               1750-1326
            volumeNumber:19
            type:
               Periodical
               PublicationVolume
         publisher:
            name:BioMed Central
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Suhyun Kim
               affiliation:
                     name:Korea Institute of Science and Technology (KIST)
                     address:
                        name:K-Laboratory, Center for Brain Disorders, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Heejung Chun
               affiliation:
                     name:Yonsei-SL Bigen Institute (YSLI), Yonsei University
                     address:
                        name:College of Pharmacy, Yonsei-SL Bigen Institute (YSLI), Yonsei University, Incheon, Republic of Korea
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Yunha Kim
               affiliation:
                     name:Korea Institute of Science and Technology (KIST)
                     address:
                        name:K-Laboratory, Center for Brain Disorders, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Yeyun Kim
               affiliation:
                     name:Korea Institute of Science and Technology (KIST)
                     address:
                        name:K-Laboratory, Center for Brain Disorders, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea
                        type:PostalAddress
                     type:Organization
                     name:Korea University
                     address:
                        name:Department of Integrated Biomedical and Life Science, Graduate School, Korea University, Seoul, Republic of Korea
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Uiyeol Park
               affiliation:
                     name:Korea Institute of Science and Technology (KIST)
                     address:
                        name:K-Laboratory, Center for Brain Disorders, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea
                        type:PostalAddress
                     type:Organization
                     name:Hanyang University Medical School
                     address:
                        name:Deaprtment of Medicine, Hanyang University Medical School, Seoul, Republic of Korea
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Jiyeon Chu
               affiliation:
                     name:Korea Institute of Science and Technology (KIST)
                     address:
                        name:K-Laboratory, Center for Brain Disorders, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea
                        type:PostalAddress
                     type:Organization
                     name:Korea University
                     address:
                        name:Department of Integrated Biomedical and Life Science, Graduate School, Korea University, Seoul, Republic of Korea
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Mridula Bhalla
               affiliation:
                     name:Center for Cognition and Sociality, Institute for Basic Science (IBS)
                     address:
                        name:Center for Cognition and Sociality, Institute for Basic Science (IBS), Daejeon, Republic of Korea
                        type:PostalAddress
                     type:Organization
                     name:University of Science and Technology (UST)
                     address:
                        name:IBS School, University of Science and Technology (UST), Daejeon, Republic of Korea
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Seung-Hye Choi
               affiliation:
                     name:Yonsei University College of Medicine
                     address:
                        name:Severance Biomedical Science Institute, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, Republic of Korea
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Ali Yousefian-Jazi
               affiliation:
                     name:Korea Institute of Science and Technology (KIST)
                     address:
                        name:K-Laboratory, Center for Brain Disorders, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Sojung Kim
               affiliation:
                     name:Korea Institute of Science and Technology (KIST)
                     address:
                        name:K-Laboratory, Center for Brain Disorders, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea
                        type:PostalAddress
                     type:Organization
                     name:Korea University
                     address:
                        name:Department of Integrated Biomedical and Life Science, Graduate School, Korea University, Seoul, Republic of Korea
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Seung Jae Hyeon
               affiliation:
                     name:Korea Institute of Science and Technology (KIST)
                     address:
                        name:K-Laboratory, Center for Brain Disorders, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Seungchan Kim
               affiliation:
                     name:Korea Institute of Science and Technology (KIST)
                     address:
                        name:K-Laboratory, Center for Brain Disorders, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Yeonseo Kim
               affiliation:
                     name:Korea Institute of Science and Technology
                     address:
                        name:Center for Advanced Biomolecular Recognition, Korea Institute of Science and Technology, Seoul, Republic of Korea
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Yeon Ha Ju
               affiliation:
                     name:Center for Cognition and Sociality, Institute for Basic Science (IBS)
                     address:
                        name:Center for Cognition and Sociality, Institute for Basic Science (IBS), Daejeon, Republic of Korea
                        type:PostalAddress
                     type:Organization
                     name:University of Science and Technology (UST)
                     address:
                        name:IBS School, University of Science and Technology (UST), Daejeon, Republic of Korea
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Seung Eun Lee
               affiliation:
                     name:Korea Institute of Science and Technology (KIST)
                     address:
                        name:Research Animal Resource Center, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Hyunbeom Lee
               affiliation:
                     name:Korea Institute of Science and Technology
                     address:
                        name:Center for Advanced Biomolecular Recognition, Korea Institute of Science and Technology, Seoul, Republic of Korea
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Kyungeun Lee
               affiliation:
                     name:Korea Institute of Science and Technology
                     address:
                        name:Advanced Analysis and Data Center, Korea Institute of Science and Technology, Seoul, Republic of Korea
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Soo-Jin Oh
               affiliation:
                     name:Korea Institute of Science and Technology (KIST)
                     address:
                        name:K-Laboratory, Center for Brain Disorders, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Eun Mi Hwang
               affiliation:
                     name:Korea Institute of Science and Technology (KIST)
                     address:
                        name:Center for Brain Function, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Junghee Lee
               affiliation:
                     name:Boston University Alzheimer’s Disease Research Center, Boston University Chobanian & Avedisian School of Medicine
                     address:
                        name:Department of Neurology, Boston University Alzheimer’s Disease Research Center, Boston University Chobanian & Avedisian School of Medicine, Boston, USA
                        type:PostalAddress
                     type:Organization
                     name:VA Boston Healthcare System
                     address:
                        name:VA Boston Healthcare System, Boston, USA
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:C. Justin Lee
               affiliation:
                     name:Center for Cognition and Sociality, Institute for Basic Science (IBS)
                     address:
                        name:Center for Cognition and Sociality, Institute for Basic Science (IBS), Daejeon, Republic of Korea
                        type:PostalAddress
                     type:Organization
                     name:University of Science and Technology (UST)
                     address:
                        name:IBS School, University of Science and Technology (UST), Daejeon, Republic of Korea
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Hoon Ryu
               url:http://orcid.org/0000-0001-6544-3732
               affiliation:
                     name:Korea Institute of Science and Technology (KIST)
                     address:
                        name:K-Laboratory, Center for Brain Disorders, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea
                        type:PostalAddress
                     type:Organization
                     name:KHU-KIST, Kyung Hee University
                     address:
                        name:Department of Converging Science and Technology, KHU-KIST, Kyung Hee University, Seoul, Republic of Korea
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:1
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Astrocytic autophagy plasticity modulates Aβ clearance and cognitive function in Alzheimer’s disease
      description:Astrocytes, one of the most resilient cells in the brain, transform into reactive astrocytes in response to toxic proteins such as amyloid beta (Aβ) in Alzheimer’s disease (AD). However, reactive astrocyte-mediated non-cell autonomous neuropathological mechanism is not fully understood yet. We aimed our study to find out whether Aβ-induced proteotoxic stress affects the expression of autophagy genes and the modulation of autophagic flux in astrocytes, and if yes, how Aβ-induced autophagy-associated genes are involved Aβ clearance in astrocytes of animal model of AD. Whole RNA sequencing (RNA-seq) was performed to detect gene expression patterns in Aβ-treated human astrocytes in a time-dependent manner. To verify the role of astrocytic autophagy in an AD mouse model, we developed AAVs expressing shRNAs for MAP1LC3B/LC3B (LC3B) and Sequestosome1 (SQSTM1) based on AAV-R-CREon vector, which is a Cre recombinase-dependent gene-silencing system. Also, the effect of astrocyte-specific overexpression of LC3B on the neuropathology in AD (APP/PS1) mice was determined. Neuropathological alterations of AD mice with astrocytic autophagy dysfunction were observed by confocal microscopy and transmission electron microscope (TEM). Behavioral changes of mice were examined through novel object recognition test (NOR) and novel object place recognition test (NOPR). Here, we show that astrocytes, unlike neurons, undergo plastic changes in autophagic processes to remove Aβ. Aβ transiently induces expression of LC3B gene and turns on a prolonged transcription of SQSTM1 gene. The Aβ-induced astrocytic autophagy accelerates urea cycle and putrescine degradation pathway. Pharmacological inhibition of autophagy exacerbates mitochondrial dysfunction and oxidative stress in astrocytes. Astrocyte-specific knockdown of LC3B and SQSTM1 significantly increases Aβ plaque formation and GFAP-positive astrocytes in APP/PS1 mice, along with a significant reduction of neuronal marker and cognitive function. In contrast, astrocyte-specific overexpression of LC3B reduced Aβ aggregates in the brain of APP/PS1 mice. An increase of LC3B and SQSTM1 protein is found in astrocytes of the hippocampus in AD patients. Taken together, our data indicates that Aβ-induced astrocytic autophagic plasticity is an important cellular event to modulate Aβ clearance and maintain cognitive function in AD mice.
      datePublished:2024-07-23T00:00:00Z
      dateModified:2024-07-23T00:00:00Z
      pageStart:1
      pageEnd:26
      license:http://creativecommons.org/publicdomain/zero/1.0/
      sameAs:https://doi.org/10.1186/s13024-024-00740-w
      keywords:
         Alzheimer’s disease
         Astrocytes
         Amyloid beta (Aβ)
         Autophagy
         Mitochondria
         Aβ clearance
         Neurosciences
         Neurology
         Molecular Medicine
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13024-024-00740-w/MediaObjects/13024_2024_740_Fig1_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13024-024-00740-w/MediaObjects/13024_2024_740_Fig2_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13024-024-00740-w/MediaObjects/13024_2024_740_Fig3_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13024-024-00740-w/MediaObjects/13024_2024_740_Fig4_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13024-024-00740-w/MediaObjects/13024_2024_740_Fig5_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13024-024-00740-w/MediaObjects/13024_2024_740_Fig6_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13024-024-00740-w/MediaObjects/13024_2024_740_Fig7_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13024-024-00740-w/MediaObjects/13024_2024_740_Fig8_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13024-024-00740-w/MediaObjects/13024_2024_740_Fig9_HTML.png
      isPartOf:
         name:Molecular Neurodegeneration
         issn:
            1750-1326
         volumeNumber:19
         type:
            Periodical
            PublicationVolume
      publisher:
         name:BioMed Central
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Suhyun Kim
            affiliation:
                  name:Korea Institute of Science and Technology (KIST)
                  address:
                     name:K-Laboratory, Center for Brain Disorders, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Heejung Chun
            affiliation:
                  name:Yonsei-SL Bigen Institute (YSLI), Yonsei University
                  address:
                     name:College of Pharmacy, Yonsei-SL Bigen Institute (YSLI), Yonsei University, Incheon, Republic of Korea
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Yunha Kim
            affiliation:
                  name:Korea Institute of Science and Technology (KIST)
                  address:
                     name:K-Laboratory, Center for Brain Disorders, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Yeyun Kim
            affiliation:
                  name:Korea Institute of Science and Technology (KIST)
                  address:
                     name:K-Laboratory, Center for Brain Disorders, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea
                     type:PostalAddress
                  type:Organization
                  name:Korea University
                  address:
                     name:Department of Integrated Biomedical and Life Science, Graduate School, Korea University, Seoul, Republic of Korea
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Uiyeol Park
            affiliation:
                  name:Korea Institute of Science and Technology (KIST)
                  address:
                     name:K-Laboratory, Center for Brain Disorders, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea
                     type:PostalAddress
                  type:Organization
                  name:Hanyang University Medical School
                  address:
                     name:Deaprtment of Medicine, Hanyang University Medical School, Seoul, Republic of Korea
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jiyeon Chu
            affiliation:
                  name:Korea Institute of Science and Technology (KIST)
                  address:
                     name:K-Laboratory, Center for Brain Disorders, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea
                     type:PostalAddress
                  type:Organization
                  name:Korea University
                  address:
                     name:Department of Integrated Biomedical and Life Science, Graduate School, Korea University, Seoul, Republic of Korea
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Mridula Bhalla
            affiliation:
                  name:Center for Cognition and Sociality, Institute for Basic Science (IBS)
                  address:
                     name:Center for Cognition and Sociality, Institute for Basic Science (IBS), Daejeon, Republic of Korea
                     type:PostalAddress
                  type:Organization
                  name:University of Science and Technology (UST)
                  address:
                     name:IBS School, University of Science and Technology (UST), Daejeon, Republic of Korea
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Seung-Hye Choi
            affiliation:
                  name:Yonsei University College of Medicine
                  address:
                     name:Severance Biomedical Science Institute, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, Republic of Korea
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Ali Yousefian-Jazi
            affiliation:
                  name:Korea Institute of Science and Technology (KIST)
                  address:
                     name:K-Laboratory, Center for Brain Disorders, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Sojung Kim
            affiliation:
                  name:Korea Institute of Science and Technology (KIST)
                  address:
                     name:K-Laboratory, Center for Brain Disorders, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea
                     type:PostalAddress
                  type:Organization
                  name:Korea University
                  address:
                     name:Department of Integrated Biomedical and Life Science, Graduate School, Korea University, Seoul, Republic of Korea
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Seung Jae Hyeon
            affiliation:
                  name:Korea Institute of Science and Technology (KIST)
                  address:
                     name:K-Laboratory, Center for Brain Disorders, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Seungchan Kim
            affiliation:
                  name:Korea Institute of Science and Technology (KIST)
                  address:
                     name:K-Laboratory, Center for Brain Disorders, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Yeonseo Kim
            affiliation:
                  name:Korea Institute of Science and Technology
                  address:
                     name:Center for Advanced Biomolecular Recognition, Korea Institute of Science and Technology, Seoul, Republic of Korea
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Yeon Ha Ju
            affiliation:
                  name:Center for Cognition and Sociality, Institute for Basic Science (IBS)
                  address:
                     name:Center for Cognition and Sociality, Institute for Basic Science (IBS), Daejeon, Republic of Korea
                     type:PostalAddress
                  type:Organization
                  name:University of Science and Technology (UST)
                  address:
                     name:IBS School, University of Science and Technology (UST), Daejeon, Republic of Korea
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Seung Eun Lee
            affiliation:
                  name:Korea Institute of Science and Technology (KIST)
                  address:
                     name:Research Animal Resource Center, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Hyunbeom Lee
            affiliation:
                  name:Korea Institute of Science and Technology
                  address:
                     name:Center for Advanced Biomolecular Recognition, Korea Institute of Science and Technology, Seoul, Republic of Korea
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Kyungeun Lee
            affiliation:
                  name:Korea Institute of Science and Technology
                  address:
                     name:Advanced Analysis and Data Center, Korea Institute of Science and Technology, Seoul, Republic of Korea
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Soo-Jin Oh
            affiliation:
                  name:Korea Institute of Science and Technology (KIST)
                  address:
                     name:K-Laboratory, Center for Brain Disorders, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Eun Mi Hwang
            affiliation:
                  name:Korea Institute of Science and Technology (KIST)
                  address:
                     name:Center for Brain Function, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Junghee Lee
            affiliation:
                  name:Boston University Alzheimer’s Disease Research Center, Boston University Chobanian & Avedisian School of Medicine
                  address:
                     name:Department of Neurology, Boston University Alzheimer’s Disease Research Center, Boston University Chobanian & Avedisian School of Medicine, Boston, USA
                     type:PostalAddress
                  type:Organization
                  name:VA Boston Healthcare System
                  address:
                     name:VA Boston Healthcare System, Boston, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:C. Justin Lee
            affiliation:
                  name:Center for Cognition and Sociality, Institute for Basic Science (IBS)
                  address:
                     name:Center for Cognition and Sociality, Institute for Basic Science (IBS), Daejeon, Republic of Korea
                     type:PostalAddress
                  type:Organization
                  name:University of Science and Technology (UST)
                  address:
                     name:IBS School, University of Science and Technology (UST), Daejeon, Republic of Korea
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Hoon Ryu
            url:http://orcid.org/0000-0001-6544-3732
            affiliation:
                  name:Korea Institute of Science and Technology (KIST)
                  address:
                     name:K-Laboratory, Center for Brain Disorders, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea
                     type:PostalAddress
                  type:Organization
                  name:KHU-KIST, Kyung Hee University
                  address:
                     name:Department of Converging Science and Technology, KHU-KIST, Kyung Hee University, Seoul, Republic of Korea
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:1
["Periodical","PublicationVolume"]:
      name:Molecular Neurodegeneration
      issn:
         1750-1326
      volumeNumber:19
Organization:
      name:BioMed Central
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Korea Institute of Science and Technology (KIST)
      address:
         name:K-Laboratory, Center for Brain Disorders, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea
         type:PostalAddress
      name:Yonsei-SL Bigen Institute (YSLI), Yonsei University
      address:
         name:College of Pharmacy, Yonsei-SL Bigen Institute (YSLI), Yonsei University, Incheon, Republic of Korea
         type:PostalAddress
      name:Korea Institute of Science and Technology (KIST)
      address:
         name:K-Laboratory, Center for Brain Disorders, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea
         type:PostalAddress
      name:Korea Institute of Science and Technology (KIST)
      address:
         name:K-Laboratory, Center for Brain Disorders, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea
         type:PostalAddress
      name:Korea University
      address:
         name:Department of Integrated Biomedical and Life Science, Graduate School, Korea University, Seoul, Republic of Korea
         type:PostalAddress
      name:Korea Institute of Science and Technology (KIST)
      address:
         name:K-Laboratory, Center for Brain Disorders, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea
         type:PostalAddress
      name:Hanyang University Medical School
      address:
         name:Deaprtment of Medicine, Hanyang University Medical School, Seoul, Republic of Korea
         type:PostalAddress
      name:Korea Institute of Science and Technology (KIST)
      address:
         name:K-Laboratory, Center for Brain Disorders, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea
         type:PostalAddress
      name:Korea University
      address:
         name:Department of Integrated Biomedical and Life Science, Graduate School, Korea University, Seoul, Republic of Korea
         type:PostalAddress
      name:Center for Cognition and Sociality, Institute for Basic Science (IBS)
      address:
         name:Center for Cognition and Sociality, Institute for Basic Science (IBS), Daejeon, Republic of Korea
         type:PostalAddress
      name:University of Science and Technology (UST)
      address:
         name:IBS School, University of Science and Technology (UST), Daejeon, Republic of Korea
         type:PostalAddress
      name:Yonsei University College of Medicine
      address:
         name:Severance Biomedical Science Institute, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, Republic of Korea
         type:PostalAddress
      name:Korea Institute of Science and Technology (KIST)
      address:
         name:K-Laboratory, Center for Brain Disorders, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea
         type:PostalAddress
      name:Korea Institute of Science and Technology (KIST)
      address:
         name:K-Laboratory, Center for Brain Disorders, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea
         type:PostalAddress
      name:Korea University
      address:
         name:Department of Integrated Biomedical and Life Science, Graduate School, Korea University, Seoul, Republic of Korea
         type:PostalAddress
      name:Korea Institute of Science and Technology (KIST)
      address:
         name:K-Laboratory, Center for Brain Disorders, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea
         type:PostalAddress
      name:Korea Institute of Science and Technology (KIST)
      address:
         name:K-Laboratory, Center for Brain Disorders, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea
         type:PostalAddress
      name:Korea Institute of Science and Technology
      address:
         name:Center for Advanced Biomolecular Recognition, Korea Institute of Science and Technology, Seoul, Republic of Korea
         type:PostalAddress
      name:Center for Cognition and Sociality, Institute for Basic Science (IBS)
      address:
         name:Center for Cognition and Sociality, Institute for Basic Science (IBS), Daejeon, Republic of Korea
         type:PostalAddress
      name:University of Science and Technology (UST)
      address:
         name:IBS School, University of Science and Technology (UST), Daejeon, Republic of Korea
         type:PostalAddress
      name:Korea Institute of Science and Technology (KIST)
      address:
         name:Research Animal Resource Center, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea
         type:PostalAddress
      name:Korea Institute of Science and Technology
      address:
         name:Center for Advanced Biomolecular Recognition, Korea Institute of Science and Technology, Seoul, Republic of Korea
         type:PostalAddress
      name:Korea Institute of Science and Technology
      address:
         name:Advanced Analysis and Data Center, Korea Institute of Science and Technology, Seoul, Republic of Korea
         type:PostalAddress
      name:Korea Institute of Science and Technology (KIST)
      address:
         name:K-Laboratory, Center for Brain Disorders, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea
         type:PostalAddress
      name:Korea Institute of Science and Technology (KIST)
      address:
         name:Center for Brain Function, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea
         type:PostalAddress
      name:Boston University Alzheimer’s Disease Research Center, Boston University Chobanian & Avedisian School of Medicine
      address:
         name:Department of Neurology, Boston University Alzheimer’s Disease Research Center, Boston University Chobanian & Avedisian School of Medicine, Boston, USA
         type:PostalAddress
      name:VA Boston Healthcare System
      address:
         name:VA Boston Healthcare System, Boston, USA
         type:PostalAddress
      name:Center for Cognition and Sociality, Institute for Basic Science (IBS)
      address:
         name:Center for Cognition and Sociality, Institute for Basic Science (IBS), Daejeon, Republic of Korea
         type:PostalAddress
      name:University of Science and Technology (UST)
      address:
         name:IBS School, University of Science and Technology (UST), Daejeon, Republic of Korea
         type:PostalAddress
      name:Korea Institute of Science and Technology (KIST)
      address:
         name:K-Laboratory, Center for Brain Disorders, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea
         type:PostalAddress
      name:KHU-KIST, Kyung Hee University
      address:
         name:Department of Converging Science and Technology, KHU-KIST, Kyung Hee University, Seoul, Republic of Korea
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Suhyun Kim
      affiliation:
            name:Korea Institute of Science and Technology (KIST)
            address:
               name:K-Laboratory, Center for Brain Disorders, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea
               type:PostalAddress
            type:Organization
      name:Heejung Chun
      affiliation:
            name:Yonsei-SL Bigen Institute (YSLI), Yonsei University
            address:
               name:College of Pharmacy, Yonsei-SL Bigen Institute (YSLI), Yonsei University, Incheon, Republic of Korea
               type:PostalAddress
            type:Organization
      name:Yunha Kim
      affiliation:
            name:Korea Institute of Science and Technology (KIST)
            address:
               name:K-Laboratory, Center for Brain Disorders, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea
               type:PostalAddress
            type:Organization
      name:Yeyun Kim
      affiliation:
            name:Korea Institute of Science and Technology (KIST)
            address:
               name:K-Laboratory, Center for Brain Disorders, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea
               type:PostalAddress
            type:Organization
            name:Korea University
            address:
               name:Department of Integrated Biomedical and Life Science, Graduate School, Korea University, Seoul, Republic of Korea
               type:PostalAddress
            type:Organization
      name:Uiyeol Park
      affiliation:
            name:Korea Institute of Science and Technology (KIST)
            address:
               name:K-Laboratory, Center for Brain Disorders, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea
               type:PostalAddress
            type:Organization
            name:Hanyang University Medical School
            address:
               name:Deaprtment of Medicine, Hanyang University Medical School, Seoul, Republic of Korea
               type:PostalAddress
            type:Organization
      name:Jiyeon Chu
      affiliation:
            name:Korea Institute of Science and Technology (KIST)
            address:
               name:K-Laboratory, Center for Brain Disorders, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea
               type:PostalAddress
            type:Organization
            name:Korea University
            address:
               name:Department of Integrated Biomedical and Life Science, Graduate School, Korea University, Seoul, Republic of Korea
               type:PostalAddress
            type:Organization
      name:Mridula Bhalla
      affiliation:
            name:Center for Cognition and Sociality, Institute for Basic Science (IBS)
            address:
               name:Center for Cognition and Sociality, Institute for Basic Science (IBS), Daejeon, Republic of Korea
               type:PostalAddress
            type:Organization
            name:University of Science and Technology (UST)
            address:
               name:IBS School, University of Science and Technology (UST), Daejeon, Republic of Korea
               type:PostalAddress
            type:Organization
      name:Seung-Hye Choi
      affiliation:
            name:Yonsei University College of Medicine
            address:
               name:Severance Biomedical Science Institute, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, Republic of Korea
               type:PostalAddress
            type:Organization
      name:Ali Yousefian-Jazi
      affiliation:
            name:Korea Institute of Science and Technology (KIST)
            address:
               name:K-Laboratory, Center for Brain Disorders, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea
               type:PostalAddress
            type:Organization
      name:Sojung Kim
      affiliation:
            name:Korea Institute of Science and Technology (KIST)
            address:
               name:K-Laboratory, Center for Brain Disorders, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea
               type:PostalAddress
            type:Organization
            name:Korea University
            address:
               name:Department of Integrated Biomedical and Life Science, Graduate School, Korea University, Seoul, Republic of Korea
               type:PostalAddress
            type:Organization
      name:Seung Jae Hyeon
      affiliation:
            name:Korea Institute of Science and Technology (KIST)
            address:
               name:K-Laboratory, Center for Brain Disorders, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea
               type:PostalAddress
            type:Organization
      name:Seungchan Kim
      affiliation:
            name:Korea Institute of Science and Technology (KIST)
            address:
               name:K-Laboratory, Center for Brain Disorders, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea
               type:PostalAddress
            type:Organization
      name:Yeonseo Kim
      affiliation:
            name:Korea Institute of Science and Technology
            address:
               name:Center for Advanced Biomolecular Recognition, Korea Institute of Science and Technology, Seoul, Republic of Korea
               type:PostalAddress
            type:Organization
      name:Yeon Ha Ju
      affiliation:
            name:Center for Cognition and Sociality, Institute for Basic Science (IBS)
            address:
               name:Center for Cognition and Sociality, Institute for Basic Science (IBS), Daejeon, Republic of Korea
               type:PostalAddress
            type:Organization
            name:University of Science and Technology (UST)
            address:
               name:IBS School, University of Science and Technology (UST), Daejeon, Republic of Korea
               type:PostalAddress
            type:Organization
      name:Seung Eun Lee
      affiliation:
            name:Korea Institute of Science and Technology (KIST)
            address:
               name:Research Animal Resource Center, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea
               type:PostalAddress
            type:Organization
      name:Hyunbeom Lee
      affiliation:
            name:Korea Institute of Science and Technology
            address:
               name:Center for Advanced Biomolecular Recognition, Korea Institute of Science and Technology, Seoul, Republic of Korea
               type:PostalAddress
            type:Organization
      name:Kyungeun Lee
      affiliation:
            name:Korea Institute of Science and Technology
            address:
               name:Advanced Analysis and Data Center, Korea Institute of Science and Technology, Seoul, Republic of Korea
               type:PostalAddress
            type:Organization
      name:Soo-Jin Oh
      affiliation:
            name:Korea Institute of Science and Technology (KIST)
            address:
               name:K-Laboratory, Center for Brain Disorders, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea
               type:PostalAddress
            type:Organization
      name:Eun Mi Hwang
      affiliation:
            name:Korea Institute of Science and Technology (KIST)
            address:
               name:Center for Brain Function, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea
               type:PostalAddress
            type:Organization
      name:Junghee Lee
      affiliation:
            name:Boston University Alzheimer’s Disease Research Center, Boston University Chobanian & Avedisian School of Medicine
            address:
               name:Department of Neurology, Boston University Alzheimer’s Disease Research Center, Boston University Chobanian & Avedisian School of Medicine, Boston, USA
               type:PostalAddress
            type:Organization
            name:VA Boston Healthcare System
            address:
               name:VA Boston Healthcare System, Boston, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:C. Justin Lee
      affiliation:
            name:Center for Cognition and Sociality, Institute for Basic Science (IBS)
            address:
               name:Center for Cognition and Sociality, Institute for Basic Science (IBS), Daejeon, Republic of Korea
               type:PostalAddress
            type:Organization
            name:University of Science and Technology (UST)
            address:
               name:IBS School, University of Science and Technology (UST), Daejeon, Republic of Korea
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Hoon Ryu
      url:http://orcid.org/0000-0001-6544-3732
      affiliation:
            name:Korea Institute of Science and Technology (KIST)
            address:
               name:K-Laboratory, Center for Brain Disorders, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea
               type:PostalAddress
            type:Organization
            name:KHU-KIST, Kyung Hee University
            address:
               name:Department of Converging Science and Technology, KHU-KIST, Kyung Hee University, Seoul, Republic of Korea
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:K-Laboratory, Center for Brain Disorders, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea
      name:College of Pharmacy, Yonsei-SL Bigen Institute (YSLI), Yonsei University, Incheon, Republic of Korea
      name:K-Laboratory, Center for Brain Disorders, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea
      name:K-Laboratory, Center for Brain Disorders, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea
      name:Department of Integrated Biomedical and Life Science, Graduate School, Korea University, Seoul, Republic of Korea
      name:K-Laboratory, Center for Brain Disorders, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea
      name:Deaprtment of Medicine, Hanyang University Medical School, Seoul, Republic of Korea
      name:K-Laboratory, Center for Brain Disorders, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea
      name:Department of Integrated Biomedical and Life Science, Graduate School, Korea University, Seoul, Republic of Korea
      name:Center for Cognition and Sociality, Institute for Basic Science (IBS), Daejeon, Republic of Korea
      name:IBS School, University of Science and Technology (UST), Daejeon, Republic of Korea
      name:Severance Biomedical Science Institute, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, Republic of Korea
      name:K-Laboratory, Center for Brain Disorders, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea
      name:K-Laboratory, Center for Brain Disorders, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea
      name:Department of Integrated Biomedical and Life Science, Graduate School, Korea University, Seoul, Republic of Korea
      name:K-Laboratory, Center for Brain Disorders, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea
      name:K-Laboratory, Center for Brain Disorders, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea
      name:Center for Advanced Biomolecular Recognition, Korea Institute of Science and Technology, Seoul, Republic of Korea
      name:Center for Cognition and Sociality, Institute for Basic Science (IBS), Daejeon, Republic of Korea
      name:IBS School, University of Science and Technology (UST), Daejeon, Republic of Korea
      name:Research Animal Resource Center, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea
      name:Center for Advanced Biomolecular Recognition, Korea Institute of Science and Technology, Seoul, Republic of Korea
      name:Advanced Analysis and Data Center, Korea Institute of Science and Technology, Seoul, Republic of Korea
      name:K-Laboratory, Center for Brain Disorders, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea
      name:Center for Brain Function, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea
      name:Department of Neurology, Boston University Alzheimer’s Disease Research Center, Boston University Chobanian & Avedisian School of Medicine, Boston, USA
      name:VA Boston Healthcare System, Boston, USA
      name:Center for Cognition and Sociality, Institute for Basic Science (IBS), Daejeon, Republic of Korea
      name:IBS School, University of Science and Technology (UST), Daejeon, Republic of Korea
      name:K-Laboratory, Center for Brain Disorders, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea
      name:Department of Converging Science and Technology, KHU-KIST, Kyung Hee University, Seoul, Republic of Korea

External Links {🔗}(220)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js
Video.js

CDN Services {📦}

Crossref

5.47s.

LINK . SPRINGER . COM {}