We are analyzing https://link.springer.com/article/10.1186/s13024-017-0161-4.

Title:
Diurnal oscillation of CSF Aβ and other AD biomarkers | Molecular Neurodegeneration
Description:
To assess stages of Alzheimer
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28 years and 1 months (reg. 1997-05-29).

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Keywords {🔍}

pubmed, article, diurnal, csf, central, biomarkers, alzheimers, disease, google, scholar, authors, fluid, cerebrospinal, amyloidβ, sampling, amyloid, lucey, concentrations, variation, sleepwake, cas, oscillation, time, lumbar, access, clinical, levels, neurol, pmcid, pmc, open, bateman, tau, app, variability, factors, studies, patients, brain, human, privacy, cookies, analysis, data, brendan, fagan, holtzman, morris, interest, found,

Topics {✒️}

enzyme-linked immunosorbent assay cerebrospinal fluid amyloid-beta-42 disrupted sleep-wake cycles influence sleep-wake cycles normal sleep-wake cycle pubmed central pmcid amyloid-β dynamics correlate article download pdf β-amyloid diurnal pattern csf amyloid-β levels molecular neurodegeneration reported central nervous system variable sampling time-points preanalytical confounding factors amyloid precursor protein integrated multi-study analysis cerebrospinal fluid levels cerebrospinal fluid biomarkers sleep-wake activity [8 privacy choices/manage cookies amyloid-β levels beta-amyloid dynamics creative commons license β-amyloid kinetics amyloid-β dynamics sleep-wake cycle ventricular cerebrospinal fluid drug-related effects amyloid-β csf injured human brain potential ad biomarkers candidate ad biomarkers article lucey ad mouse models european economic area proteins wakefulness background intensive care units highly standardized protocols sci transl med conditions privacy policy aβ diurnal pattern alter diurnal patterns identify diurnal patterns lumbar punctures performed repeated measures anova healthy older volunteers true diurnal variation alzheimers res ther indwelling lumbar catheters volume-related disturbances

Questions {❓}

Author’s response: Is there an association of diurnal variation with cerebrospinal fluid biomarkers for Alzheimer’s disease?

Schema {🗺️}

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         headline:Diurnal oscillation of CSF Aβ and other AD biomarkers
         description:To assess stages of Alzheimer's disease (AD) pathogenesis and the efficacy of drugs during clinical trials, there has been immense interest in the field to establish baseline cerebrospinal fluid (CSF) concentrations for potential AD biomarkers such as amyloid-β (Aβ) and tau. Significant within-person variations in CSF Aβ concentrations over time found that this variation followed the sleep-wake cycle. A recent paper in Molecular Neurodegeneration reported the absence of diurnal variations in multiple classical and candidate AD biomarkers, such as soluble APP, Aβ, tau, p-tau, YKL-40, VILIP-1, or apolipoprotein E. This commentary addresses these apparently discordant results regarding the diurnal variability of APP and Aβ compared with the literature. Despite our concerns, we appreciate the authors' interest in this important topic and contribution to improve our knowledge about the factors influencing Aβ diurnal variation.
         datePublished:2017-05-08T00:00:00Z
         dateModified:2017-05-08T00:00:00Z
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               email:[email protected]
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ScholarlyArticle:
      headline:Diurnal oscillation of CSF Aβ and other AD biomarkers
      description:To assess stages of Alzheimer's disease (AD) pathogenesis and the efficacy of drugs during clinical trials, there has been immense interest in the field to establish baseline cerebrospinal fluid (CSF) concentrations for potential AD biomarkers such as amyloid-β (Aβ) and tau. Significant within-person variations in CSF Aβ concentrations over time found that this variation followed the sleep-wake cycle. A recent paper in Molecular Neurodegeneration reported the absence of diurnal variations in multiple classical and candidate AD biomarkers, such as soluble APP, Aβ, tau, p-tau, YKL-40, VILIP-1, or apolipoprotein E. This commentary addresses these apparently discordant results regarding the diurnal variability of APP and Aβ compared with the literature. Despite our concerns, we appreciate the authors' interest in this important topic and contribution to improve our knowledge about the factors influencing Aβ diurnal variation.
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      dateModified:2017-05-08T00:00:00Z
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         Amyloid-β
         Biomarkers
         Neurosciences
         Neurology
         Molecular Medicine
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