We are analyzing https://link.springer.com/article/10.1186/s12979-020-00187-9.

Title:
Role of immune cells in the removal of deleterious senescent cells | Immunity & Ageing
Description:
Cellular senescence is an essentially irreversible arrest of cell proliferation coupled to a complex senescence-associated secretory phenotype (SASP). The senescence arrest prevents the development of cancer, and the SASP can promote tissue repair. Recent data suggest that the prolonged presence of senescent cells, and especially the SASP, could be deleterious, and their beneficial effects early in life can become maladaptive such that they drive aging phenotypes and pathologies late in life. It is therefore important to develop strategies to eliminate senescent cells. There are currently under development or approved several immune cell-based therapies for cancer, which could be redesigned to target senescent cells. This review focuses on this possible use of immune cells and discusses how current cell-based therapies could be used for senescent cell removal.
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Keywords {🔍}

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Topics {✒️}

perforin-mediated target-cell death aging-related inflammation driven current cell-based therapies immune cell-based therapies sens research foundation macrophage-based cell therapies article download pdf nk cell-based immunotherapy enhanced nk-cell susceptibility cell-based cancer immunotherapy small-cell lung cancer proper macrophage-dependent elimination galactosidase-positive macrophage accumulation escape nk-mediated killing hla-e-mediated nk pro-inflammatory senescent cells anti-aging strategies based cell stem cell amit sharma produce ‘pro-inflammatory’ molecules thymus-derived cells mature nk cell-mediated clearance graft-versus-host disease age-related decline h2o2 involves dna-damage cell-autonomous tumor suppression senescence immune surveillance cdk/cell cycle inhibitor potent anti-cancer mechanism cd38+ pro-inflammatory macrophages gene therapy manufacturing car t-cell bioengineering age-related pathologies [21 p53-dependent chemokine production senescent-specific surface markers cell-based therapies natural killer cells oncogene-expressing senescent melanocytes tau protein aggregation hall bm nitric oxide synthase-2 stimulate cell growth assess cellular senescence wiley cd cell therapy tumor necrosis factor age-dependent decline cells undergoing senescence pro-regenerative environment nk cell targeting

Questions {❓}

, Arsenovi?
Aging of mice is associated with p16(Ink4a)- and ?
Macrophage polarization in chronic inflammatory diseases: killers or builders?
Review article: ageing and the neutrophil: no appetite for killing?
What do we mean when we write “senescence,” “apoptosis,” “necrosis,” or “clearance of dying cells”?
P16(Ink4a) and senescence-associated ?

Schema {🗺️}

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         headline:Role of immune cells in the removal of deleterious senescent cells
         description:Cellular senescence is an essentially irreversible arrest of cell proliferation coupled to a complex senescence-associated secretory phenotype (SASP). The senescence arrest prevents the development of cancer, and the SASP can promote tissue repair. Recent data suggest that the prolonged presence of senescent cells, and especially the SASP, could be deleterious, and their beneficial effects early in life can become maladaptive such that they drive aging phenotypes and pathologies late in life. It is therefore important to develop strategies to eliminate senescent cells. There are currently under development or approved several immune cell-based therapies for cancer, which could be redesigned to target senescent cells. This review focuses on this possible use of immune cells and discusses how current cell-based therapies could be used for senescent cell removal.
         datePublished:2020-06-03T00:00:00Z
         dateModified:2020-06-03T00:00:00Z
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      headline:Role of immune cells in the removal of deleterious senescent cells
      description:Cellular senescence is an essentially irreversible arrest of cell proliferation coupled to a complex senescence-associated secretory phenotype (SASP). The senescence arrest prevents the development of cancer, and the SASP can promote tissue repair. Recent data suggest that the prolonged presence of senescent cells, and especially the SASP, could be deleterious, and their beneficial effects early in life can become maladaptive such that they drive aging phenotypes and pathologies late in life. It is therefore important to develop strategies to eliminate senescent cells. There are currently under development or approved several immune cell-based therapies for cancer, which could be redesigned to target senescent cells. This review focuses on this possible use of immune cells and discusses how current cell-based therapies could be used for senescent cell removal.
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         Cell-based therapy
         Cellular senescence
         Immune surveillance
         Inflammation
         Macrophages
         Natural killer cells
         Immunology
         Geriatrics/Gerontology
         Aging
         Public Health
         Clinical Nutrition
         Antibodies
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      name:Amit Sharma
      affiliation:
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            address:
               name:SENS Research Foundation, Mountain View, USA
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      affiliation:
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            address:
               name:SENS Research Foundation, Mountain View, USA
               type:PostalAddress
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      name:Buck Institute for Research on Aging, Novato, USA
      name:California Pacific Medical Center, Research Institute, San Francisco, USA
      name:Buck Institute for Research on Aging, Novato, USA
      name:Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, USA

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