Here's how LINK.SPRINGER.COM makes money* and how much!

*Please read our disclaimer before using our estimates.
Loading...

LINK . SPRINGER . COM {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Link.springer.com Make Money
  6. Keywords
  7. Topics
  8. Questions
  9. Schema
  10. External Links
  11. Analytics And Tracking
  12. Libraries
  13. CDN Services

We are analyzing https://link.springer.com/article/10.1186/s12974-023-02866-y.

Title:
Lysosomal acidification dysfunction in microglia: an emerging pathogenic mechanism of neuroinflammation and neurodegeneration | Journal of Neuroinflammation
Description:
Microglia are the resident innate immune cells in the brain with a major role in orchestrating immune responses. They also provide a frontline of host defense in the central nervous system (CNS) through their active phagocytic capability. Being a professional phagocyte, microglia participate in phagocytic and autophagic clearance of cellular waste and debris as well as toxic protein aggregates, which relies on optimal lysosomal acidification and function. Defective microglial lysosomal acidification leads to impaired phagocytic and autophagic functions which result in the perpetuation of neuroinflammation and progression of neurodegeneration. Reacidification of impaired lysosomes in microglia has been shown to reverse neurodegenerative pathology in Alzheimer’s disease. In this review, we summarize key factors and mechanisms contributing to lysosomal acidification impairment and the associated phagocytic and autophagic dysfunction in microglia, and how these defects contribute to neuroinflammation and neurodegeneration. We further discuss techniques to monitor lysosomal pH and therapeutic agents that can reacidify impaired lysosomes in microglia under disease conditions. Finally, we propose future directions to investigate the role of microglial lysosomal acidification in lysosome–mitochondria crosstalk and in neuron–glia interaction for more comprehensive understanding of its broader CNS physiological and pathological implications.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

  • Education
  • Science
  • Environment

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We don’t know how the website earns money.

While many websites aim to make money, others are created to share knowledge or showcase creativity. People build websites for various reasons. This could be one of them. Link.springer.com might have a hidden revenue stream, but it's not something we can detect.

Keywords {🔍}

lysosomal, pubmed, microglia, google, scholar, acidification, cas, microglial, central, function, disease, neuroinflammation, cells, cell, lysosomes, protein, shown, neurodegeneration, brain, role, inflammatory, mouse, alzheimers, dysfunction, autophagy, autophagic, degradation, activity, impaired, activation, neurosci, sci, phagocytosis, neuronal, fig, cytokines, lipid, phagocytic, leading, lysosome, including, article, cytokine, increased, release, membrane, accumulation, aging, cellular, vatpase,

Topics {✒️}

chih hung lo nuclear factor-κb/p65 responds app β-c-terminal fragment macrophage colony-stimulating factor age-related neurodegenerative diseases conditioned medium-induced toxicity lysosome-targeting acidic nanoparticles amyloid β-induced redistribution early-onset familial ad tmem106b-induced lysosome enlargement decreased v-atpase activity early-onset genetic mutations lipid-induced lysosomal damage impaired γ-secretase activity almeida-da-silva clc pro-inflammatory cytokines released article download pdf activate v-atpase activity pro-inflammatory genes inos purinergic receptors signaling inflammatory cytokines ifn-ɣ soluble oligomeric aβ toxic protein aggregates acidic nanoparticles protect α-synuclein-induced neurodegeneration brain-disease dependent-inflammatory response central nervous system selective v-atpase inhibition endo-lysosomal aβ concentration activate v-atpase function kah leong lim wide-ranging cellular implications cell-specific effect remains preventing autophagosome-lysosome fusion facilitating autophagosome-lysosome fusion nuclear factor kappa endosome/lysosomal environment clc-7 chloride transporter lysosome-targeting nanoparticles γ-secretase complex microglial lysosomal–autophagic pathway lysosome-directed nanoparticles glial-mediated inflammation soluble adenylyl cyclase author information authors lo ch distinct profiles sensitive fluorescent probes induced lysosomal damage exhibit differential effects

Questions {❓}

  • Inflammation and α-Synuclein’s prion-like behavior in Parkinson’s disease—is there a link?
  • M1 and M2 immune activation in Parkinson’s disease: foe and ally?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Lysosomal acidification dysfunction in microglia: an emerging pathogenic mechanism of neuroinflammation and neurodegeneration
         description:Microglia are the resident innate immune cells in the brain with a major role in orchestrating immune responses. They also provide a frontline of host defense in the central nervous system (CNS) through their active phagocytic capability. Being a professional phagocyte, microglia participate in phagocytic and autophagic clearance of cellular waste and debris as well as toxic protein aggregates, which relies on optimal lysosomal acidification and function. Defective microglial lysosomal acidification leads to impaired phagocytic and autophagic functions which result in the perpetuation of neuroinflammation and progression of neurodegeneration. Reacidification of impaired lysosomes in microglia has been shown to reverse neurodegenerative pathology in Alzheimer’s disease. In this review, we summarize key factors and mechanisms contributing to lysosomal acidification impairment and the associated phagocytic and autophagic dysfunction in microglia, and how these defects contribute to neuroinflammation and neurodegeneration. We further discuss techniques to monitor lysosomal pH and therapeutic agents that can reacidify impaired lysosomes in microglia under disease conditions. Finally, we propose future directions to investigate the role of microglial lysosomal acidification in lysosome–mitochondria crosstalk and in neuron–glia interaction for more comprehensive understanding of its broader CNS physiological and pathological implications.
         datePublished:2023-08-05T00:00:00Z
         dateModified:2023-08-05T00:00:00Z
         pageStart:1
         pageEnd:13
         license:http://creativecommons.org/publicdomain/zero/1.0/
         sameAs:https://doi.org/10.1186/s12974-023-02866-y
         keywords:
            Lysosomal acidification
            Autophagy
            Phagocytosis
            Cytokines
            Toxic protein aggregates
            Neuroinflammation
            Neurodegenerative diseases
            Acidic nanoparticles
            Neurosciences
            Neurology
            Neurobiology
            Immunology
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12974-023-02866-y/MediaObjects/12974_2023_2866_Fig1_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12974-023-02866-y/MediaObjects/12974_2023_2866_Fig2_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12974-023-02866-y/MediaObjects/12974_2023_2866_Fig3_HTML.png
         isPartOf:
            name:Journal of Neuroinflammation
            issn:
               1742-2094
            volumeNumber:20
            type:
               Periodical
               PublicationVolume
         publisher:
            name:BioMed Central
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Joseph D. Quick
               affiliation:
                     name:Medical School, University of Minnesota
                     address:
                        name:Department of Integrative Biology and Physiology, Medical School, University of Minnesota, Minneapolis, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Cristian Silva
               affiliation:
                     name:University of Kelaniya
                     address:
                        name:Faculty of Graduate Studies, University of Kelaniya, Kelaniya, Sri Lanka
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Jia Hui Wong
               affiliation:
                     name:Lee Kong Chian School of Medicine, Nanyang Technological University
                     address:
                        name:Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Kah Leong Lim
               affiliation:
                     name:Lee Kong Chian School of Medicine, Nanyang Technological University
                     address:
                        name:Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore
                        type:PostalAddress
                     type:Organization
                     name:Imperial College London
                     address:
                        name:Department of Brain Sciences, Faculty of Medicine, Imperial College London, London, UK
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Richard Reynolds
               affiliation:
                     name:Lee Kong Chian School of Medicine, Nanyang Technological University
                     address:
                        name:Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore
                        type:PostalAddress
                     type:Organization
                     name:Imperial College London
                     address:
                        name:Department of Brain Sciences, Faculty of Medicine, Imperial College London, London, UK
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Anna M. Barron
               affiliation:
                     name:Lee Kong Chian School of Medicine, Nanyang Technological University
                     address:
                        name:Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Jialiu Zeng
               affiliation:
                     name:Lee Kong Chian School of Medicine, Nanyang Technological University
                     address:
                        name:Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Chih Hung Lo
               affiliation:
                     name:Lee Kong Chian School of Medicine, Nanyang Technological University
                     address:
                        name:Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:1
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Lysosomal acidification dysfunction in microglia: an emerging pathogenic mechanism of neuroinflammation and neurodegeneration
      description:Microglia are the resident innate immune cells in the brain with a major role in orchestrating immune responses. They also provide a frontline of host defense in the central nervous system (CNS) through their active phagocytic capability. Being a professional phagocyte, microglia participate in phagocytic and autophagic clearance of cellular waste and debris as well as toxic protein aggregates, which relies on optimal lysosomal acidification and function. Defective microglial lysosomal acidification leads to impaired phagocytic and autophagic functions which result in the perpetuation of neuroinflammation and progression of neurodegeneration. Reacidification of impaired lysosomes in microglia has been shown to reverse neurodegenerative pathology in Alzheimer’s disease. In this review, we summarize key factors and mechanisms contributing to lysosomal acidification impairment and the associated phagocytic and autophagic dysfunction in microglia, and how these defects contribute to neuroinflammation and neurodegeneration. We further discuss techniques to monitor lysosomal pH and therapeutic agents that can reacidify impaired lysosomes in microglia under disease conditions. Finally, we propose future directions to investigate the role of microglial lysosomal acidification in lysosome–mitochondria crosstalk and in neuron–glia interaction for more comprehensive understanding of its broader CNS physiological and pathological implications.
      datePublished:2023-08-05T00:00:00Z
      dateModified:2023-08-05T00:00:00Z
      pageStart:1
      pageEnd:13
      license:http://creativecommons.org/publicdomain/zero/1.0/
      sameAs:https://doi.org/10.1186/s12974-023-02866-y
      keywords:
         Lysosomal acidification
         Autophagy
         Phagocytosis
         Cytokines
         Toxic protein aggregates
         Neuroinflammation
         Neurodegenerative diseases
         Acidic nanoparticles
         Neurosciences
         Neurology
         Neurobiology
         Immunology
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12974-023-02866-y/MediaObjects/12974_2023_2866_Fig1_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12974-023-02866-y/MediaObjects/12974_2023_2866_Fig2_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12974-023-02866-y/MediaObjects/12974_2023_2866_Fig3_HTML.png
      isPartOf:
         name:Journal of Neuroinflammation
         issn:
            1742-2094
         volumeNumber:20
         type:
            Periodical
            PublicationVolume
      publisher:
         name:BioMed Central
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Joseph D. Quick
            affiliation:
                  name:Medical School, University of Minnesota
                  address:
                     name:Department of Integrative Biology and Physiology, Medical School, University of Minnesota, Minneapolis, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Cristian Silva
            affiliation:
                  name:University of Kelaniya
                  address:
                     name:Faculty of Graduate Studies, University of Kelaniya, Kelaniya, Sri Lanka
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jia Hui Wong
            affiliation:
                  name:Lee Kong Chian School of Medicine, Nanyang Technological University
                  address:
                     name:Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Kah Leong Lim
            affiliation:
                  name:Lee Kong Chian School of Medicine, Nanyang Technological University
                  address:
                     name:Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore
                     type:PostalAddress
                  type:Organization
                  name:Imperial College London
                  address:
                     name:Department of Brain Sciences, Faculty of Medicine, Imperial College London, London, UK
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Richard Reynolds
            affiliation:
                  name:Lee Kong Chian School of Medicine, Nanyang Technological University
                  address:
                     name:Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore
                     type:PostalAddress
                  type:Organization
                  name:Imperial College London
                  address:
                     name:Department of Brain Sciences, Faculty of Medicine, Imperial College London, London, UK
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Anna M. Barron
            affiliation:
                  name:Lee Kong Chian School of Medicine, Nanyang Technological University
                  address:
                     name:Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jialiu Zeng
            affiliation:
                  name:Lee Kong Chian School of Medicine, Nanyang Technological University
                  address:
                     name:Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Chih Hung Lo
            affiliation:
                  name:Lee Kong Chian School of Medicine, Nanyang Technological University
                  address:
                     name:Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:1
["Periodical","PublicationVolume"]:
      name:Journal of Neuroinflammation
      issn:
         1742-2094
      volumeNumber:20
Organization:
      name:BioMed Central
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Medical School, University of Minnesota
      address:
         name:Department of Integrative Biology and Physiology, Medical School, University of Minnesota, Minneapolis, USA
         type:PostalAddress
      name:University of Kelaniya
      address:
         name:Faculty of Graduate Studies, University of Kelaniya, Kelaniya, Sri Lanka
         type:PostalAddress
      name:Lee Kong Chian School of Medicine, Nanyang Technological University
      address:
         name:Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore
         type:PostalAddress
      name:Lee Kong Chian School of Medicine, Nanyang Technological University
      address:
         name:Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore
         type:PostalAddress
      name:Imperial College London
      address:
         name:Department of Brain Sciences, Faculty of Medicine, Imperial College London, London, UK
         type:PostalAddress
      name:Lee Kong Chian School of Medicine, Nanyang Technological University
      address:
         name:Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore
         type:PostalAddress
      name:Imperial College London
      address:
         name:Department of Brain Sciences, Faculty of Medicine, Imperial College London, London, UK
         type:PostalAddress
      name:Lee Kong Chian School of Medicine, Nanyang Technological University
      address:
         name:Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore
         type:PostalAddress
      name:Lee Kong Chian School of Medicine, Nanyang Technological University
      address:
         name:Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore
         type:PostalAddress
      name:Lee Kong Chian School of Medicine, Nanyang Technological University
      address:
         name:Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Joseph D. Quick
      affiliation:
            name:Medical School, University of Minnesota
            address:
               name:Department of Integrative Biology and Physiology, Medical School, University of Minnesota, Minneapolis, USA
               type:PostalAddress
            type:Organization
      name:Cristian Silva
      affiliation:
            name:University of Kelaniya
            address:
               name:Faculty of Graduate Studies, University of Kelaniya, Kelaniya, Sri Lanka
               type:PostalAddress
            type:Organization
      name:Jia Hui Wong
      affiliation:
            name:Lee Kong Chian School of Medicine, Nanyang Technological University
            address:
               name:Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore
               type:PostalAddress
            type:Organization
      name:Kah Leong Lim
      affiliation:
            name:Lee Kong Chian School of Medicine, Nanyang Technological University
            address:
               name:Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore
               type:PostalAddress
            type:Organization
            name:Imperial College London
            address:
               name:Department of Brain Sciences, Faculty of Medicine, Imperial College London, London, UK
               type:PostalAddress
            type:Organization
      name:Richard Reynolds
      affiliation:
            name:Lee Kong Chian School of Medicine, Nanyang Technological University
            address:
               name:Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore
               type:PostalAddress
            type:Organization
            name:Imperial College London
            address:
               name:Department of Brain Sciences, Faculty of Medicine, Imperial College London, London, UK
               type:PostalAddress
            type:Organization
      name:Anna M. Barron
      affiliation:
            name:Lee Kong Chian School of Medicine, Nanyang Technological University
            address:
               name:Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore
               type:PostalAddress
            type:Organization
      name:Jialiu Zeng
      affiliation:
            name:Lee Kong Chian School of Medicine, Nanyang Technological University
            address:
               name:Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Chih Hung Lo
      affiliation:
            name:Lee Kong Chian School of Medicine, Nanyang Technological University
            address:
               name:Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Integrative Biology and Physiology, Medical School, University of Minnesota, Minneapolis, USA
      name:Faculty of Graduate Studies, University of Kelaniya, Kelaniya, Sri Lanka
      name:Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore
      name:Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore
      name:Department of Brain Sciences, Faculty of Medicine, Imperial College London, London, UK
      name:Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore
      name:Department of Brain Sciences, Faculty of Medicine, Imperial College London, London, UK
      name:Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore
      name:Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore
      name:Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore

External Links {🔗}(366)

Analytics and Tracking {📊}

  • Google Tag Manager

Libraries {📚}

  • Clipboard.js
  • Prism.js

CDN Services {📦}

  • Crossref

5.86s.