We are analyzing https://link.springer.com/article/10.1186/s12974-022-02672-y.

Title:
The YTHDF1–TRAF6 pathway regulates the neuroinflammatory response and contributes to morphine tolerance and hyperalgesia in the periaqueductal gray | Journal of Neuroinflammation
Description:
Long-term use of opioids such as morphine has negative side effects, such as morphine analgesic tolerance and morphine-induced hyperalgesia (MIH). These side effects limit the clinical use and analgesic efficacy of morphine. Elucidation of the mechanisms and identification of feasible and effective methods or treatment targets to solve this clinical phenomenon are important. Here, we discovered that YTHDF1 and TNF receptor-associated factor 6 (TRAF6) are crucial for morphine analgesic tolerance and MIH. The m6A reader YTHDF1 positively regulated the translation of TRAF6 mRNA, and chronic morphine treatments enhanced the m6A modification of TRAF6 mRNA. TRAF6 protein expression was drastically reduced by YTHDF1 knockdown, although TRAF6 mRNA levels were unaffected. By reducing inflammatory markers such as IL-1β, IL-6, TNF-α and NF-κB, targeted reduction of YTHDF1 or suppression of TRAF6 activity in ventrolateral periaqueductal gray (vlPAG) slows the development of morphine analgesic tolerance and MIH. Our findings provide new insights into the mechanism of morphine analgesic tolerance and MIH indicating that YTHDF1 regulates inflammatory factors such as IL-1β, IL-6, TNF-α and NF-κB by enhancing TRAF6 protein expression.
Website Age:
28 years and 1 months (reg. 1997-05-29).

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Keywords {🔍}

morphine, tolerance, ythdf, article, google, scholar, vlpag, analgesic, traf, cas, group, expression, mice, day, mih, inflammatory, chronic, zhang, min, response, ilβ, tnfα, nfκb, hyperalgesia, fig, wang, hot, treatments, factors, tail, pain, spinal, plate, morphineinduced, mrna, shown, rna, immersion, data, translation, signaling, inhibition, percent, change, knockdown, ythdfflfl, pathway, regulates, huang, opioid,

Topics {✒️}

cmv-ythdf1-shrna-nc = aav-cmv-cre + aav-cmv-dio-egfp-ythdf1-shrna-nc cmv-ythdf1-shrna = aav-cmv-cre + aav-cmv-dio-egfp-ythdf1-shrna aav-cmv-cre + aav-cmv-dio-egfp-ythdf1-shrna-negative control aav-cmv-cre + aav-cmv-dio-egfp-ythdf1-shrna avv-cmv-cre + aav-cmv-dio-egfp-ythdf1-shrna aav-cmv-dio-ythdf1-shrna-nc virus c-jun n-terminal kinase aav-cmv-dio-ythdf1-shrna delivered aav-cmv-cre-egfp aav-cmv-cre-egfp aav-cmv-egfp control virus cmv-ythdf1-shrna-nc tumor necrosis factor-α avv-cmv-cre-egfp cmv-cre-egfp relative %input = 1/10 × 2ct[ip] – ct[input] aav-cmv-egfp cmv-cre-egfp group sepsis-induced myocardial injury cmv-cre-egfp morphine-induced anti-nociceptive tolerance sun yat-sen university cerebral ischemia/reperfusion injury wnt/β-catenin signaling wnt/beta-catenin signaling cmv-ythdf1-shrna post-morphine + 30 min time points 30-gauge stainless-steel cannula paradoxical opioid-induced hyperalgesia gel electrophoresis sds-page shrna-nc group nikon ds-qi2 camera hif-1α-induced expression ubiquitin-conjugating enzyme ubc13 ythdf1-clip analysis showed morphine-induced analgesic tolerance p-jnk expression induced regulate opioid-induced neuroinflammation cmv-egfp group qing-hai pharmaceutical factory ythdf1–traf6 pathway regulates article download pdf irak1/traf6 signaling pathway n6-methyladenosine-dependent regulation 10 μg anti-m6a antibody ythdf1 regulated negatively promotes cap-independent translation cy3-conjugated secondary antibodies nuclear factor-κb nf-κb signaling pathway

Questions {❓}

Perioperative opioid analgesia-when is enough too much?

Schema {🗺️}

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      name:Department of Anesthesiology, State Key Laboratory of Oncology in Southern China, Sun Yat-sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China
      name:Department of Anesthesiology, State Key Laboratory of Oncology in Southern China, Sun Yat-sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China
      name:Department of Anesthesiology, State Key Laboratory of Oncology in Southern China, Sun Yat-sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China
      name:Department of Anesthesiology, State Key Laboratory of Oncology in Southern China, Sun Yat-sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China
      name:Department of Anesthesiology, State Key Laboratory of Oncology in Southern China, Sun Yat-sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China
      name:Department of Anesthesiology, State Key Laboratory of Oncology in Southern China, Sun Yat-sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China
      name:Department of Anesthesiology, Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China

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