We are analyzing https://link.springer.com/article/10.1186/s12974-015-0357-x.

Title:
‘Medusa head ataxia’: the expanding spectrum of Purkinje cell antibodies in autoimmune cerebellar ataxia. Part 2: Anti-PKC-gamma, anti-GluR-delta2, anti-Ca/ARHGAP26 and anti-VGCC | Journal of Neuroinflammation
Description:
Serological testing for anti-neural autoantibodies is important in patients presenting with idiopathic cerebellar ataxia, since these autoantibodies may indicate cancer, determine treatment and predict prognosis. While some of them target nuclear antigens present in all or most CNS neurons (e.g. anti-Hu, anti-Ri), others more specifically target antigens present in the cytoplasm or plasma membrane of Purkinje cells (PC). In this series of articles, we provide a detailed review of the clinical and paraclinical features, oncological, therapeutic and prognostic implications, pathogenetic relevance, and differential laboratory diagnosis of the 12 most common PC autoantibodies (often referred to as ‘Medusa head antibodies’ due their characteristic somatodendritic binding pattern when tested by immunohistochemistry). To assist immunologists and neurologists in diagnosing these disorders, typical high-resolution immunohistochemical images of all 12 reactivities are presented, diagnostic pitfalls discussed and all currently available assays reviewed. Of note, most of these antibodies target antigens involved in the mGluR1/calcium pathway essential for PC function and survival. Many of the antigens also play a role in spinocerebellar ataxia. Part 1 focuses on anti-metabotropic glutamate receptor 1-, anti-Homer protein homolog 3-, anti-Sj/inositol 1,4,5-trisphosphate receptor- and anti-carbonic anhydrase-related protein VIII-associated autoimmune cerebellar ataxia (ACA); part 2 covers anti-protein kinase C gamma-, anti-glutamate receptor delta-2-, anti-Ca/RhoGTPase-activating protein 26- and anti-voltage-gated calcium channel-associated ACA; and part 3 reviews the current knowledge on anti-Tr/delta notch-like epidermal growth factor-related receptor-, anti-Nb/AP3B2-, anti-Yo/cerebellar degeneration-related protein 2- and Purkinje cell antibody 2-associated ACA, discusses differential diagnostic aspects, and provides a summary and outlook.
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pubmed, google, scholar, article, cas, cerebellar, ataxia, antibodies, patients, receptor, protein, cell, patient, central, glutamate, calcium, channel, vgcc, reported, cerebellum, purkinje, pcd, cells, kinase, delta, pkcγ, symptoms, glurδ, autoantibodies, membrane, antibody, arhgap, channels, lems, paraneoplastic, mice, neurol, igg, degeneration, human, mutations, syndrome, csf, cases, cancer, receptors, binding, gene, sca, cav,

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α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid dentato-rubro-pallido-luysian atrophy locus dihydropyridine-insensitive high-voltage threshold-activated 125i-ω-conotoxin mviic-based assay section entitled anti-yo/cdr2/cdr62 n-methyl-d-aspartate nmo 125i-ω-conotoxin mviic assay r-type-defining alpha1e subunit anti-voltage-gated calcium channel anti-voltage-gated calcium channel l-type vgcc-related alpha1d 125i-ω-conotoxin gvia anti-ca/rhogtpase-activating protein 26 anti-ca/rhogtpase-activating protein 26 125i-ω-conotoxin mviic voltage-gated calcium channel high-resolution immunogold cytochemistry voltage-gated calcium channels voltage-gated ca2+ channels cell–cell/cell–matrix contacts /q-type vgcc-specific antibodies pkcγ-specific cell-based assay anti-vgcc-specific antibody index voltage-dependent calcium channels bin–amphiphysin–rvs beta-nap fak/pak-binding sh3 domain lambert-eaton myasthenic syndrome enzyme-linked immunosorbent assays calcium-activated potassium channels abnormal vestibulo-ocular reflex small g-protein signalling ligand-dependent manner mediated type calcium-channel antibodies clic/geec endocytic pathway anti-ca/anti-arhgap26 antibodies g-protein-coupled receptors clathrin-mediated endocytotic pathway anti-ca/arhgap26-positive serum t-cell-mediated mechanisms /q-type calcium channels avidin–biotin immunoperoxidase ihc anti-ca/arhgap26-positive sera rho gtpase-activating protein rho-gtpase-activating protein q-type calcium currents single-channel conductance kinetics anti-glutamate receptor delta-2 anti-glutamate receptor delta-2 modulating bin–amphiphysin–rvs c-terminal coding region

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Acute limbic encephalitis: a new entity?
Non-herpetic acute limbic encephalitis: a new subgroup of limbic encephalitis?

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         headline:‘Medusa head ataxia’: the expanding spectrum of Purkinje cell antibodies in autoimmune cerebellar ataxia. Part 2: Anti-PKC-gamma, anti-GluR-delta2, anti-Ca/ARHGAP26 and anti-VGCC
         description:Serological testing for anti-neural autoantibodies is important in patients presenting with idiopathic cerebellar ataxia, since these autoantibodies may indicate cancer, determine treatment and predict prognosis. While some of them target nuclear antigens present in all or most CNS neurons (e.g. anti-Hu, anti-Ri), others more specifically target antigens present in the cytoplasm or plasma membrane of Purkinje cells (PC). In this series of articles, we provide a detailed review of the clinical and paraclinical features, oncological, therapeutic and prognostic implications, pathogenetic relevance, and differential laboratory diagnosis of the 12 most common PC autoantibodies (often referred to as ‘Medusa head antibodies’ due their characteristic somatodendritic binding pattern when tested by immunohistochemistry). To assist immunologists and neurologists in diagnosing these disorders, typical high-resolution immunohistochemical images of all 12 reactivities are presented, diagnostic pitfalls discussed and all currently available assays reviewed. Of note, most of these antibodies target antigens involved in the mGluR1/calcium pathway essential for PC function and survival. Many of the antigens also play a role in spinocerebellar ataxia. Part 1 focuses on anti-metabotropic glutamate receptor 1-, anti-Homer protein homolog 3-, anti-Sj/inositol 1,4,5-trisphosphate receptor- and anti-carbonic anhydrase-related protein VIII-associated autoimmune cerebellar ataxia (ACA); part 2 covers anti-protein kinase C gamma-, anti-glutamate receptor delta-2-, anti-Ca/RhoGTPase-activating protein 26- and anti-voltage-gated calcium channel-associated ACA; and part 3 reviews the current knowledge on anti-Tr/delta notch-like epidermal growth factor-related receptor-, anti-Nb/AP3B2-, anti-Yo/cerebellar degeneration-related protein 2- and Purkinje cell antibody 2-associated ACA, discusses differential diagnostic aspects, and provides a summary and outlook.
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            Paraneoplastic cerebellar degeneration
            Autoantibodies
            Purkinje cells
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            Homer-3 antibodies
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            Anti-Nb
            Anti-AP3B2
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            Neurosciences
            Neurology
            Neurobiology
            Immunology
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      headline:‘Medusa head ataxia’: the expanding spectrum of Purkinje cell antibodies in autoimmune cerebellar ataxia. Part 2: Anti-PKC-gamma, anti-GluR-delta2, anti-Ca/ARHGAP26 and anti-VGCC
      description:Serological testing for anti-neural autoantibodies is important in patients presenting with idiopathic cerebellar ataxia, since these autoantibodies may indicate cancer, determine treatment and predict prognosis. While some of them target nuclear antigens present in all or most CNS neurons (e.g. anti-Hu, anti-Ri), others more specifically target antigens present in the cytoplasm or plasma membrane of Purkinje cells (PC). In this series of articles, we provide a detailed review of the clinical and paraclinical features, oncological, therapeutic and prognostic implications, pathogenetic relevance, and differential laboratory diagnosis of the 12 most common PC autoantibodies (often referred to as ‘Medusa head antibodies’ due their characteristic somatodendritic binding pattern when tested by immunohistochemistry). To assist immunologists and neurologists in diagnosing these disorders, typical high-resolution immunohistochemical images of all 12 reactivities are presented, diagnostic pitfalls discussed and all currently available assays reviewed. Of note, most of these antibodies target antigens involved in the mGluR1/calcium pathway essential for PC function and survival. Many of the antigens also play a role in spinocerebellar ataxia. Part 1 focuses on anti-metabotropic glutamate receptor 1-, anti-Homer protein homolog 3-, anti-Sj/inositol 1,4,5-trisphosphate receptor- and anti-carbonic anhydrase-related protein VIII-associated autoimmune cerebellar ataxia (ACA); part 2 covers anti-protein kinase C gamma-, anti-glutamate receptor delta-2-, anti-Ca/RhoGTPase-activating protein 26- and anti-voltage-gated calcium channel-associated ACA; and part 3 reviews the current knowledge on anti-Tr/delta notch-like epidermal growth factor-related receptor-, anti-Nb/AP3B2-, anti-Yo/cerebellar degeneration-related protein 2- and Purkinje cell antibody 2-associated ACA, discusses differential diagnostic aspects, and provides a summary and outlook.
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      keywords:
         Autoimmune cerebellar ataxia
         Cerebellitis
         Paraneoplastic cerebellar degeneration
         Autoantibodies
         Purkinje cells
         Metabotropic glutamate receptor 1 (mGluR1) antibodies
         Homer-3 antibodies
         Anti-Sj
         Inositol 1,4,5-trisphosphate receptor 1 (ITPR1, I3PR) antibodies
         Carbonic anhydrase-related protein VIII (CARP VIII) antibodies
         Protein kinase gamma (PKCγ) antibodies
         Anti-Ca
         Rho GTPase activating protein 26 (ARHGAP26, GRAF) antibodies
         Glutamate receptor delta-2 (GluRδ2) antibodies
         Anti-Yo
         Cerebellar degeneration-related protein 2 (CDR2) antibodies
         Cerebellar degeneration-related protein 2-like (CDR2L) antibodies
         Purkinje cell antibody 2 (PCA-2)
         Anti-Tr
         Delta notch-like epidermal growth factor-related receptor (DNER) antibodies
         Anti-Nb
         Anti-AP3B2
         Neuronal adaptin-like protein (beta-NAP) antibodies
         Voltage-gated calcium channel (VGCC) antibodies
         Neurosciences
         Neurology
         Neurobiology
         Immunology
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