We are analyzing https://link.springer.com/article/10.1186/s12967-023-04133-3.

Title:
Mitochondria-derived vesicles and their potential roles in kidney stone disease | Journal of Translational Medicine
Description:
Recent evidence has shown significant roles of mitochondria-derived vesicles (MDVs) in mitochondrial quality control (MQC) system. Under mild stress condition, MDVs are formed to carry the malfunctioned mitochondrial components, such as mitochondrial DNA (mtDNA), peptides, proteins and lipids, to be eliminated to restore normal mitochondrial structure and functions. Under severe oxidative stress condition, mitochondrial dynamics (fission/fusion) and mitophagy are predominantly activated to rescue mitochondrial structure and functions. Additionally, MDVs generation can be also triggered as the major MQC machinery to cope with unhealthy mitochondria when mitophagy is unsuccessful for eliminating the damaged mitochondria or mitochondrial fission/fusion fail to recover the mitochondrial structure and functions. This review summarizes the current knowledge on MDVs and discuss their roles in physiologic and pathophysiologic conditions. In addition, the potential clinical relevance of MDVs in therapeutics and diagnostics of kidney stone disease (KSD) are emphasized.
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Keywords {🔍}

pubmed, article, google, scholar, mitochondrial, mdvs, cas, central, vesicles, cell, mitochondria, extracellular, cells, kidney, formation, stress, stone, oxidative, control, proteins, roles, system, renal, mitophagy, ksd, dysfunction, oxalate, functions, injury, disease, wang, biol, quality, mqc, calcium, diseases, exosomes, specific, liu, potential, thongboonkerd, protein, role, mitochondrialderived, components, tissue, studies, damage, res, damaged,

Topics {✒️}

pka-drp1-mitochondrial fission signaling methicillin-resistant staphylococcus aureus reactive oxygen species radiation-induced systemic immunosuppression article download pdf broncho-alveolar lavage fluid oxalate-induced oxidative stress oxidative stress-induced stimuli crystal-induced kidney injury nucleotide-binding oligomerization domain mitochondrial-derived vesicles compensate circulating mitochondrial-derived vesicles incomplete drp1-knockdown condition hbv-infected human hepatocytes dominguez-gutierrez pr brain-derived extracellular vesicles calcium/phosphorus physiology differ mitochondria-anchored protein ligase low-metastatic tumor cells google scholar hypoxia-inducible factor 1α ros-induced oxidative damage er-derived pre-peroxisomes monitors vesicular transport calcium oxalate nephrolithiasis calcium oxalate crystal mdvs-mediated antigen presentation brain endothelial cells mesenchymal stem cells mitochondrial fission/fusion fails emerging cell-free approach mitochondrial fission/fusion fail mitochondria-rich extracellular vesicles parkin-independent mitophagy contributes trigger pro-inflammatory response inhibit pro-inflammatory activation myocardial ischemic/hypoxic injury article chaiyarit renal epithelial cells structured illumination microscopy calcium oxalate crystals calcium oxalate stones msc-evs transferring mitochondria translational medicine aims extracellular vesicle heterogeneity including steady-state mdvs small double-membrane evs require high-resolution isolation mitochondrial extracellular vesicles—origins ordinarily transport vesicles

Questions {❓}

Do extracellular vesicles derived from mesenchymal stem cells contain functional mitochondria?
Immunomodulatory role of mitochondrial DAMPs: a missing link in pathology?
Mitochondria-power players in kidney function?
Urinary extracellular vesicles: does cargo reflect tissue?

Schema {🗺️}

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         headline:Mitochondria-derived vesicles and their potential roles in kidney stone disease
         description:Recent evidence has shown significant roles of mitochondria-derived vesicles (MDVs) in mitochondrial quality control (MQC) system. Under mild stress condition, MDVs are formed to carry the malfunctioned mitochondrial components, such as mitochondrial DNA (mtDNA), peptides, proteins and lipids, to be eliminated to restore normal mitochondrial structure and functions. Under severe oxidative stress condition, mitochondrial dynamics (fission/fusion) and mitophagy are predominantly activated to rescue mitochondrial structure and functions. Additionally, MDVs generation can be also triggered as the major MQC machinery to cope with unhealthy mitochondria when mitophagy is unsuccessful for eliminating the damaged mitochondria or mitochondrial fission/fusion fail to recover the mitochondrial structure and functions. This review summarizes the current knowledge on MDVs and discuss their roles in physiologic and pathophysiologic conditions. In addition, the potential clinical relevance of MDVs in therapeutics and diagnostics of kidney stone disease (KSD) are emphasized.
         datePublished:2023-05-02T00:00:00Z
         dateModified:2023-07-11T00:00:00Z
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      headline:Mitochondria-derived vesicles and their potential roles in kidney stone disease
      description:Recent evidence has shown significant roles of mitochondria-derived vesicles (MDVs) in mitochondrial quality control (MQC) system. Under mild stress condition, MDVs are formed to carry the malfunctioned mitochondrial components, such as mitochondrial DNA (mtDNA), peptides, proteins and lipids, to be eliminated to restore normal mitochondrial structure and functions. Under severe oxidative stress condition, mitochondrial dynamics (fission/fusion) and mitophagy are predominantly activated to rescue mitochondrial structure and functions. Additionally, MDVs generation can be also triggered as the major MQC machinery to cope with unhealthy mitochondria when mitophagy is unsuccessful for eliminating the damaged mitochondria or mitochondrial fission/fusion fail to recover the mitochondrial structure and functions. This review summarizes the current knowledge on MDVs and discuss their roles in physiologic and pathophysiologic conditions. In addition, the potential clinical relevance of MDVs in therapeutics and diagnostics of kidney stone disease (KSD) are emphasized.
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