We are analyzing https://link.springer.com/article/10.1186/s12967-022-03405-8.

Title:
Patient-derived xenograft (PDX) models, applications and challenges in cancer research | Journal of Translational Medicine
Description:
The establishing of the first cancer models created a new perspective on the identification and evaluation of new anti-cancer therapies in preclinical studies. Patient-derived xenograft models are created by tumor tissue engraftment. These models accurately represent the biology and heterogeneity of different cancers and recapitulate tumor microenvironment. These features have made it a reliable model along with the development of humanized models. Therefore, they are used in many studies, such as the development of anti-cancer drugs, co-clinical trials, personalized medicine, immunotherapy, and PDX biobanks. This review summarizes patient-derived xenograft models development procedures, drug development applications in various cancers, challenges and limitations.
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Keywords {🔍}

models, cancer, pubmed, google, scholar, article, tumor, pdx, cas, model, mice, patientderived, human, cells, central, xenograft, cell, drug, clinical, xenografts, preclinical, humanized, research, mouse, tissue, development, animal, immune, res, studies, trials, rate, breast, prostate, lung, tumors, patients, primary, medicine, personalized, system, clin, engraftment, colorectal, cancers, table, establishment, oncol, evaluation, immunotherapy,

Topics {✒️}

anti-pd-1/pd-l1 immunotherapy nod/ltsz-scid/scid mice small-cell lung carcinoma patient-derived tumour xenografts cell-line derived xenografts establishing patient-derived xenografts cancer-related female death patient-derived cell line pdx patient-derived xenograft patient-derived xenograft models patient-derived xenograft model create patient-derived xenograft small-cell lung cancer patient-derived tumor xenografts evaluating cell-based therapies myeloid-derived suppressor cells post-transplant lymphoproliferative disorder article download pdf nod/scid/γcnull mouse patient-derived models repository nod/ltsz-scid mice patient-derived tumor cells c57bl/6j-scid bgmice patient-derived tumor organoids cb-17-scid/scid mice models accurately represent nod-scid il2rγnull mice humanized immune-pdx models patient-derived xenograft studying tumor progression-related patient-derived xenografts immune-deficient mice pdx-bearing humanized mice nu/nu athymic mice cetuximab-resistant colorectal cancer cell-based therapies [60] numerous pre-clinical trials recapitulate tumor microenvironment triple-negative breast cancer evaluate anti-cancer therapies evaluate anti-mesothelin car pd-l1 expression pd-1-targeted cancer immunotherapy drug-resistant pdx models human colorectal carcinoma long-term storage site patient-derived models mahshid saleh kaveh baghaei performing pre-clinical studies

Questions {❓}

Any challenges?
High drug attrition rates—where are we going wrong?
Patient-derived xenografts of non-small-cell lung cancer: a pre-clinical model to evaluate adjuvant chemotherapy?

Schema {🗺️}

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         Humanized model
         Avatar model of cancer
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         general
         Medicine/Public Health
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      name:Cell-Based Therapies Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran
      name:Department of Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
      name:Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran
      name:Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran

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