We are analyzing https://link.springer.com/article/10.1186/s12967-022-03337-3.

Title:
Study effect of probiotics and prebiotics on treatment of OVA-LPS-induced of allergic asthma inflammation and pneumonia by regulating the TLR4/NF-kB signaling pathway | Journal of Translational Medicine
Description:
Asthma is a common respiratory disease, and immune system dysregulation has direct relevance to asthma pathogenesis. Probiotics and prebiotics have immunomodulatory effects and can regulate immune responses and may attenuate allergic reactions. Therefore, in this study, we explored the role of probiotics and prebiotics in regulating acute airway inflammation and the TLR4/NF-kB pathway. Allergic asthma model of BALB/c mice was produced and treated with probiotics (LA-5, GG, and BB-12) and prebiotics (FOS and GOS). Then AHR, BALF cells count, EPO activity, IL-4, 5, 13, 17, 25, 33, as well as IFN-γ, total and OVA-specific IgE, IgG1, Cys-LT, LTB4, LTC4, and TSLP levels were measured. Also, the GTP/GOT assay was performed and gene expression of Akt, NLR3, NF-kB, PI3K, MyD88, TLR4, CCL11, CCL24, MUC5a, Eotaxin, IL-38, and IL-8 were determined. Finally, lung histopathological features were evaluated. Treatment with probiotics could control AHR, eosinophil infiltration to the BALF and reduce the levels of immunoglobulins, IL-17, GTP and also decrease mucus secretion, goblet cell hyperplasia, peribronchial and perivascular inflammation and also, EPO activity. It could reduce gene expression of TLR4 and CCL11. On the other hand, IL-38 gene expression was increased by both probiotic and prebiotic treatment. Treatment with probiotics and prebiotics could control levels of IL-4, 5, 13, 25, 33, leukotrienes, the gene expression of AKT, NLR3, NF-κB, MyD88, MUC5a. The prebiotic treatment could control peribronchial inflammation and PI3K gene expression. Both of the treatments had no significant effect on the GOT, TSLP and IL-8, eotaxin and CCL24 gene expression. Probiotics and prebiotics could induce tolerance in allegro-inflammatory reactions and alter immune responses in allergic conditions. Probiotics could also modulate cellular and humoral immune responses and prevent allergic disorders.
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Keywords {🔍}

probiotics, asthma, prebiotics, expression, allergic, probiotic, article, treatment, mice, group, inflammation, google, scholar, tlr, cells, control, levels, study, balf, gene, prebiotic, compared, effect, ovalps, asthmatic, cell, significantly, immune, animals, increased, ige, ccl, significant, production, responses, cytokines, signaling, lps, ova, airway, treated, inflammatory, effects, groups, decreased, ahr, treatments, reduced, total, myd,

Topics {✒️}

tgf-β/smad/bcl2/caspase/lc3 cascade nuclear factor kappa-light-chain-enhancer modulating ampk/pi3k/akt/p38-nf-κb tlr4/nf‐κb-mediated immune responses immune-mediated anti-microbial activity tlr4/nf-kb signaling pathway lps/tlr4/nf-kb pathway [9 tlr4-mediated nf-kb activation ova-lps sensitized/challenged group lps-ova-induced lung injury ova-lps-induced asthmatic mice tlr4-myd88-nfκb signaling pathway tlr4/nf‐κb signaling pathways seyyed shamsadin athari th2-related pro-inflammatory cytokines th1-related pro-inflammatory cytokine tgf-β-producing cells ova-lps-sensitized mice compared lwt-food sci technol article download pdf 1 mm o-phenylenediamine dihydrochloride tlr4/nf-kb pathway ova-lps sensitization/challenge animals balancing th1/th2 responses retinoic acid-inducible gene alleviating lps/tlr4 axis introducing inulin-type fructans modulating cd11c + cell functionality risperidone-induced oxidative stress ova-lps sensitized mice ova-lps-sensitized mice severe bronchospasm/airway hyperreactivity ova-lps challenged mice pre-biotic treated reduced pro-/pre-biotics implicated pre-biotic treated animals ova-lps challenge resulted pre-biotics treated mice angii-induced ros production th2-related allergic responses treated ova-lps group allegro-immune response related ova-lps-treated mice th2-type inflammatory cytokines treated ova-lps groups ova + lps control group ova-lps asthmatic animals allegro-inflammatory airway asthma increased t-bet expression ova-lps sensitization/challenge

Questions {❓}

Can probiotics be used in the prevention and treatment of bronchial asthma?
Immunomodulatory effects of probiotics: Can they be used to treat allergies and autoimmune diseases?

Schema {🗺️}

WebPage:
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         headline:Study effect of probiotics and prebiotics on treatment of OVA-LPS-induced of allergic asthma inflammation and pneumonia by regulating the TLR4/NF-kB signaling pathway
         description:Asthma is a common respiratory disease, and immune system dysregulation has direct relevance to asthma pathogenesis. Probiotics and prebiotics have immunomodulatory effects and can regulate immune responses and may attenuate allergic reactions. Therefore, in this study, we explored the role of probiotics and prebiotics in regulating acute airway inflammation and the TLR4/NF-kB pathway. Allergic asthma model of BALB/c mice was produced and treated with probiotics (LA-5, GG, and BB-12) and prebiotics (FOS and GOS). Then AHR, BALF cells count, EPO activity, IL-4, 5, 13, 17, 25, 33, as well as IFN-γ, total and OVA-specific IgE, IgG1, Cys-LT, LTB4, LTC4, and TSLP levels were measured. Also, the GTP/GOT assay was performed and gene expression of Akt, NLR3, NF-kB, PI3K, MyD88, TLR4, CCL11, CCL24, MUC5a, Eotaxin, IL-38, and IL-8 were determined. Finally, lung histopathological features were evaluated. Treatment with probiotics could control AHR, eosinophil infiltration to the BALF and reduce the levels of immunoglobulins, IL-17, GTP and also decrease mucus secretion, goblet cell hyperplasia, peribronchial and perivascular inflammation and also, EPO activity. It could reduce gene expression of TLR4 and CCL11. On the other hand, IL-38 gene expression was increased by both probiotic and prebiotic treatment. Treatment with probiotics and prebiotics could control levels of IL-4, 5, 13, 25, 33, leukotrienes, the gene expression of AKT, NLR3, NF-κB, MyD88, MUC5a. The prebiotic treatment could control peribronchial inflammation and PI3K gene expression. Both of the treatments had no significant effect on the GOT, TSLP and IL-8, eotaxin and CCL24 gene expression. Probiotics and prebiotics could induce tolerance in allegro-inflammatory reactions and alter immune responses in allergic conditions. Probiotics could also modulate cellular and humoral immune responses and prevent allergic disorders.
         datePublished:2022-03-16T00:00:00Z
         dateModified:2022-03-16T00:00:00Z
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            Microbe
            Diet
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            Biomedicine
            general
            Medicine/Public Health
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ScholarlyArticle:
      headline:Study effect of probiotics and prebiotics on treatment of OVA-LPS-induced of allergic asthma inflammation and pneumonia by regulating the TLR4/NF-kB signaling pathway
      description:Asthma is a common respiratory disease, and immune system dysregulation has direct relevance to asthma pathogenesis. Probiotics and prebiotics have immunomodulatory effects and can regulate immune responses and may attenuate allergic reactions. Therefore, in this study, we explored the role of probiotics and prebiotics in regulating acute airway inflammation and the TLR4/NF-kB pathway. Allergic asthma model of BALB/c mice was produced and treated with probiotics (LA-5, GG, and BB-12) and prebiotics (FOS and GOS). Then AHR, BALF cells count, EPO activity, IL-4, 5, 13, 17, 25, 33, as well as IFN-γ, total and OVA-specific IgE, IgG1, Cys-LT, LTB4, LTC4, and TSLP levels were measured. Also, the GTP/GOT assay was performed and gene expression of Akt, NLR3, NF-kB, PI3K, MyD88, TLR4, CCL11, CCL24, MUC5a, Eotaxin, IL-38, and IL-8 were determined. Finally, lung histopathological features were evaluated. Treatment with probiotics could control AHR, eosinophil infiltration to the BALF and reduce the levels of immunoglobulins, IL-17, GTP and also decrease mucus secretion, goblet cell hyperplasia, peribronchial and perivascular inflammation and also, EPO activity. It could reduce gene expression of TLR4 and CCL11. On the other hand, IL-38 gene expression was increased by both probiotic and prebiotic treatment. Treatment with probiotics and prebiotics could control levels of IL-4, 5, 13, 25, 33, leukotrienes, the gene expression of AKT, NLR3, NF-κB, MyD88, MUC5a. The prebiotic treatment could control peribronchial inflammation and PI3K gene expression. Both of the treatments had no significant effect on the GOT, TSLP and IL-8, eotaxin and CCL24 gene expression. Probiotics and prebiotics could induce tolerance in allegro-inflammatory reactions and alter immune responses in allergic conditions. Probiotics could also modulate cellular and humoral immune responses and prevent allergic disorders.
      datePublished:2022-03-16T00:00:00Z
      dateModified:2022-03-16T00:00:00Z
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      pageEnd:14
      license:http://creativecommons.org/publicdomain/zero/1.0/
      sameAs:https://doi.org/10.1186/s12967-022-03337-3
      keywords:
         Allergy
         Microbe
         Diet
         Immunomodulation
         Asthma
         Biomedicine
         general
         Medicine/Public Health
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         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12967-022-03337-3/MediaObjects/12967_2022_3337_Fig1_HTML.png
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      address:
         name:Department of Cardiology, School of Medicine, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
         type:PostalAddress
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      address:
         name:Department of Pharmacognosy and Phytochemistry, SGT College of Pharmacy, SGT University, Gurugram, India
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            address:
               name:General Internal Medicine Ward, Zhengzhou Central Hospital Affiliated To Zhengzhou University, Zhengzhou City, China
               type:PostalAddress
            type:Organization
      name:Entezar Mehrabi Nasab
      affiliation:
            name:Tehran Heart Center, Tehran University of Medical Sciences
            address:
               name:Department of Cardiology, School of Medicine, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
               type:PostalAddress
            type:Organization
      name:Poonam Arora
      affiliation:
            name:SGT College of Pharmacy, SGT University
            address:
               name:Department of Pharmacognosy and Phytochemistry, SGT College of Pharmacy, SGT University, Gurugram, India
               type:PostalAddress
            type:Organization
      name:Seyyed Shamsadin Athari
      affiliation:
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            address:
               name:Department of Immunology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
               type:PostalAddress
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PostalAddress:
      name:General Internal Medicine Ward, Zhengzhou Central Hospital Affiliated To Zhengzhou University, Zhengzhou City, China
      name:Department of Cardiology, School of Medicine, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
      name:Department of Pharmacognosy and Phytochemistry, SGT College of Pharmacy, SGT University, Gurugram, India
      name:Department of Immunology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran

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