We are analyzing https://link.springer.com/article/10.1186/s12964-020-00538-5.

Title:
IL-9 and IL-9-producing cells in tumor immunity | Cell Communication and Signaling
Description:
Abstract Interleukin (IL)-9 belongs to the IL-2Rγc chain family and is a multifunctional cytokine that can regulate the function of many kinds of cells. It was originally identified as a growth factor of T cells and mast cells. In previous studies, IL-9 was mainly involved in the development of allergic diseases, autoimmune diseases and parasite infections. Recently, IL-9, as a double-edged sword in the development of cancers, has attracted extensive attention. Since T-helper 9 (Th9) cell-derived IL-9 was verified to play a powerful antitumor role in solid tumors, an increasing number of researchers have started to pay attention to the role of IL-9-skewed CD8+ T (Tc9) cells, mast cells and Vδ2 T cell-derived IL-9 in tumor immunity. Here, we review recent studies on IL-9 and several kinds of IL-9-producing cells in tumor immunity to provide useful insight into tumorigenesis and treatment. Video Abstract Graphical abstract
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Science
Education
Health & Fitness

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We're unsure if the website is profiting.

The purpose of some websites isn't monetary gain; they're meant to inform, educate, or foster collaboration. Everyone has unique reasons for building websites. This could be an example. Link.springer.com has a revenue plan, but it's either invisible or we haven't found it.

Keywords {🔍}

cells, pubmed, article, google, scholar, tumor, cas, antitumor, immunity, cell, cancer, central, mast, effect, promote, mice, role, immunol, differentiation, ilproducing, wang, tumors, growth, expression, immune, diseases, melanoma, chen, promotes, zhang, function, factor, nat, clin, development, survival, human, lymphoma, subset, addition, regulate, allergic, solid, inhibit, patients, studies, cellderived, breast, adaptive, production,

Topics {✒️}

tnf-α-pd-l1 pathway pi3k-akt-mtor signaling pathways mir-200a/beta-catenin axis cell-induced immune suppression mir-200a/β-catenin axis promoting ccl20/ccr6-dependent recruitment conventional ifn-γ-producing cd8+ tumour-promoting role article download pdf long-lasting anti-tumor effect t-bet transcription factor modulating pi3k→fe00akt→gsk3β→ il-2rγc chain family cell-deficient mice dna-binding inhibitor id3 myeloid-derived suppressor cells cd4+ t-cell subset cd4 t-cell subset pmel-1/b16 melanoma models inducing il-9-producing helper b16 tumor-bearing mice cd8+ t-lymphocyte production mast cell-derived il-9 restrain stat1-mediated inhibition nf-κb signaling pathway experimental melanoma-bearing mice b16-ova-bearing cd45 mc38-gp100 tumor model human melanoma-infiltrating cd4 th9 cell-derived il-9 tumor-specific th9 cells tc1 cell-transferred mice janus kinase/stat pathway th9il-4 + il-1β cells nf-κb-dependent manner t-cell subset il-22-producing human vgamma2vdelta2 ccl20 induces epithelial-stromal membrane-bound form il-21-dependent anticancer functions short-lived effector cd8 tnfr-related protein 6 lymph nodes increased professional antigen-presentation function cell growth factor il-9-producing th9 cells t-helper 9 il-9-derived th9 cells targeting c-myc dna cell biol

Schema {🗺️}

WebPage:
      mainEntity:
         headline:IL-9 and IL-9-producing cells in tumor immunity
         description:Interleukin (IL)-9 belongs to the IL-2Rγc chain family and is a multifunctional cytokine that can regulate the function of many kinds of cells. It was originally identified as a growth factor of T cells and mast cells. In previous studies, IL-9 was mainly involved in the development of allergic diseases, autoimmune diseases and parasite infections. Recently, IL-9, as a double-edged sword in the development of cancers, has attracted extensive attention. Since T-helper 9 (Th9) cell-derived IL-9 was verified to play a powerful antitumor role in solid tumors, an increasing number of researchers have started to pay attention to the role of IL-9-skewed CD8+ T (Tc9) cells, mast cells and Vδ2 T cell-derived IL-9 in tumor immunity. Here, we review recent studies on IL-9 and several kinds of IL-9-producing cells in tumor immunity to provide useful insight into tumorigenesis and treatment.
         datePublished:2020-03-30T00:00:00Z
         dateModified:2020-03-30T00:00:00Z
         pageStart:1
         pageEnd:11
         license:http://creativecommons.org/publicdomain/zero/1.0/
         sameAs:https://doi.org/10.1186/s12964-020-00538-5
         keywords:
            IL-9
            Th9
            Tc9
            Mast cells
            Tumor
            Tumor diseases
            Cell Biology
            Protein-Ligand Interactions
            Receptors
            Cytokines and Growth Factors
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12964-020-00538-5/MediaObjects/12964_2020_538_Figa_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12964-020-00538-5/MediaObjects/12964_2020_538_Fig1_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12964-020-00538-5/MediaObjects/12964_2020_538_Fig2_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12964-020-00538-5/MediaObjects/12964_2020_538_Fig3_HTML.png
         isPartOf:
            name:Cell Communication and Signaling
            issn:
               1478-811X
            volumeNumber:18
            type:
               Periodical
               PublicationVolume
         publisher:
            name:BioMed Central
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Jie Wan
               affiliation:
                     name:Jiangsu University
                     address:
                        name:Department of Immunology, Jiangsu University, Zhenjiang, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Yinqiu Wu
               affiliation:
                     name:Jiangsu University
                     address:
                        name:Department of Immunology, Jiangsu University, Zhenjiang, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Xiaoyun Ji
               affiliation:
                     name:Jiangsu University
                     address:
                        name:Department of Immunology, Jiangsu University, Zhenjiang, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Lan Huang
               affiliation:
                     name:Jiangsu University
                     address:
                        name:Department of Immunology, Jiangsu University, Zhenjiang, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Wei Cai
               affiliation:
                     name:Jiangsu University
                     address:
                        name:Department of Immunology, Jiangsu University, Zhenjiang, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Zhaoliang Su
               affiliation:
                     name:Jiangsu University
                     address:
                        name:Department of Immunology, Jiangsu University, Zhenjiang, China
                        type:PostalAddress
                     type:Organization
                     name:Jiangsu University
                     address:
                        name:China International Genomics Research Center (IGRC), Jiangsu University, Zhenjiang, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Shengjun Wang
               affiliation:
                     name:Jiangsu University
                     address:
                        name:Department of Immunology, Jiangsu University, Zhenjiang, China
                        type:PostalAddress
                     type:Organization
                     name:Jiangsu University
                     address:
                        name:Department of Laboratory Medicine, The Affiliated People’s Hospital, Jiangsu University, Zhenjiang, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Huaxi Xu
               url:https://orcid.org/0000-0002-2568-7393
               affiliation:
                     name:Jiangsu University
                     address:
                        name:Department of Immunology, Jiangsu University, Zhenjiang, China
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:1
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:IL-9 and IL-9-producing cells in tumor immunity
      description:Interleukin (IL)-9 belongs to the IL-2Rγc chain family and is a multifunctional cytokine that can regulate the function of many kinds of cells. It was originally identified as a growth factor of T cells and mast cells. In previous studies, IL-9 was mainly involved in the development of allergic diseases, autoimmune diseases and parasite infections. Recently, IL-9, as a double-edged sword in the development of cancers, has attracted extensive attention. Since T-helper 9 (Th9) cell-derived IL-9 was verified to play a powerful antitumor role in solid tumors, an increasing number of researchers have started to pay attention to the role of IL-9-skewed CD8+ T (Tc9) cells, mast cells and Vδ2 T cell-derived IL-9 in tumor immunity. Here, we review recent studies on IL-9 and several kinds of IL-9-producing cells in tumor immunity to provide useful insight into tumorigenesis and treatment.
      datePublished:2020-03-30T00:00:00Z
      dateModified:2020-03-30T00:00:00Z
      pageStart:1
      pageEnd:11
      license:http://creativecommons.org/publicdomain/zero/1.0/
      sameAs:https://doi.org/10.1186/s12964-020-00538-5
      keywords:
         IL-9
         Th9
         Tc9
         Mast cells
         Tumor
         Tumor diseases
         Cell Biology
         Protein-Ligand Interactions
         Receptors
         Cytokines and Growth Factors
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12964-020-00538-5/MediaObjects/12964_2020_538_Figa_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12964-020-00538-5/MediaObjects/12964_2020_538_Fig1_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12964-020-00538-5/MediaObjects/12964_2020_538_Fig2_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12964-020-00538-5/MediaObjects/12964_2020_538_Fig3_HTML.png
      isPartOf:
         name:Cell Communication and Signaling
         issn:
            1478-811X
         volumeNumber:18
         type:
            Periodical
            PublicationVolume
      publisher:
         name:BioMed Central
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Jie Wan
            affiliation:
                  name:Jiangsu University
                  address:
                     name:Department of Immunology, Jiangsu University, Zhenjiang, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Yinqiu Wu
            affiliation:
                  name:Jiangsu University
                  address:
                     name:Department of Immunology, Jiangsu University, Zhenjiang, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Xiaoyun Ji
            affiliation:
                  name:Jiangsu University
                  address:
                     name:Department of Immunology, Jiangsu University, Zhenjiang, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Lan Huang
            affiliation:
                  name:Jiangsu University
                  address:
                     name:Department of Immunology, Jiangsu University, Zhenjiang, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Wei Cai
            affiliation:
                  name:Jiangsu University
                  address:
                     name:Department of Immunology, Jiangsu University, Zhenjiang, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Zhaoliang Su
            affiliation:
                  name:Jiangsu University
                  address:
                     name:Department of Immunology, Jiangsu University, Zhenjiang, China
                     type:PostalAddress
                  type:Organization
                  name:Jiangsu University
                  address:
                     name:China International Genomics Research Center (IGRC), Jiangsu University, Zhenjiang, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Shengjun Wang
            affiliation:
                  name:Jiangsu University
                  address:
                     name:Department of Immunology, Jiangsu University, Zhenjiang, China
                     type:PostalAddress
                  type:Organization
                  name:Jiangsu University
                  address:
                     name:Department of Laboratory Medicine, The Affiliated People’s Hospital, Jiangsu University, Zhenjiang, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Huaxi Xu
            url:https://orcid.org/0000-0002-2568-7393
            affiliation:
                  name:Jiangsu University
                  address:
                     name:Department of Immunology, Jiangsu University, Zhenjiang, China
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:1
["Periodical","PublicationVolume"]:
      name:Cell Communication and Signaling
      issn:
         1478-811X
      volumeNumber:18
Organization:
      name:BioMed Central
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Jiangsu University
      address:
         name:Department of Immunology, Jiangsu University, Zhenjiang, China
         type:PostalAddress
      name:Jiangsu University
      address:
         name:Department of Immunology, Jiangsu University, Zhenjiang, China
         type:PostalAddress
      name:Jiangsu University
      address:
         name:Department of Immunology, Jiangsu University, Zhenjiang, China
         type:PostalAddress
      name:Jiangsu University
      address:
         name:Department of Immunology, Jiangsu University, Zhenjiang, China
         type:PostalAddress
      name:Jiangsu University
      address:
         name:Department of Immunology, Jiangsu University, Zhenjiang, China
         type:PostalAddress
      name:Jiangsu University
      address:
         name:Department of Immunology, Jiangsu University, Zhenjiang, China
         type:PostalAddress
      name:Jiangsu University
      address:
         name:China International Genomics Research Center (IGRC), Jiangsu University, Zhenjiang, China
         type:PostalAddress
      name:Jiangsu University
      address:
         name:Department of Immunology, Jiangsu University, Zhenjiang, China
         type:PostalAddress
      name:Jiangsu University
      address:
         name:Department of Laboratory Medicine, The Affiliated People’s Hospital, Jiangsu University, Zhenjiang, China
         type:PostalAddress
      name:Jiangsu University
      address:
         name:Department of Immunology, Jiangsu University, Zhenjiang, China
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Jie Wan
      affiliation:
            name:Jiangsu University
            address:
               name:Department of Immunology, Jiangsu University, Zhenjiang, China
               type:PostalAddress
            type:Organization
      name:Yinqiu Wu
      affiliation:
            name:Jiangsu University
            address:
               name:Department of Immunology, Jiangsu University, Zhenjiang, China
               type:PostalAddress
            type:Organization
      name:Xiaoyun Ji
      affiliation:
            name:Jiangsu University
            address:
               name:Department of Immunology, Jiangsu University, Zhenjiang, China
               type:PostalAddress
            type:Organization
      name:Lan Huang
      affiliation:
            name:Jiangsu University
            address:
               name:Department of Immunology, Jiangsu University, Zhenjiang, China
               type:PostalAddress
            type:Organization
      name:Wei Cai
      affiliation:
            name:Jiangsu University
            address:
               name:Department of Immunology, Jiangsu University, Zhenjiang, China
               type:PostalAddress
            type:Organization
      name:Zhaoliang Su
      affiliation:
            name:Jiangsu University
            address:
               name:Department of Immunology, Jiangsu University, Zhenjiang, China
               type:PostalAddress
            type:Organization
            name:Jiangsu University
            address:
               name:China International Genomics Research Center (IGRC), Jiangsu University, Zhenjiang, China
               type:PostalAddress
            type:Organization
      name:Shengjun Wang
      affiliation:
            name:Jiangsu University
            address:
               name:Department of Immunology, Jiangsu University, Zhenjiang, China
               type:PostalAddress
            type:Organization
            name:Jiangsu University
            address:
               name:Department of Laboratory Medicine, The Affiliated People’s Hospital, Jiangsu University, Zhenjiang, China
               type:PostalAddress
            type:Organization
      name:Huaxi Xu
      url:https://orcid.org/0000-0002-2568-7393
      affiliation:
            name:Jiangsu University
            address:
               name:Department of Immunology, Jiangsu University, Zhenjiang, China
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Immunology, Jiangsu University, Zhenjiang, China
      name:Department of Immunology, Jiangsu University, Zhenjiang, China
      name:Department of Immunology, Jiangsu University, Zhenjiang, China
      name:Department of Immunology, Jiangsu University, Zhenjiang, China
      name:Department of Immunology, Jiangsu University, Zhenjiang, China
      name:Department of Immunology, Jiangsu University, Zhenjiang, China
      name:China International Genomics Research Center (IGRC), Jiangsu University, Zhenjiang, China
      name:Department of Immunology, Jiangsu University, Zhenjiang, China
      name:Department of Laboratory Medicine, The Affiliated People’s Hospital, Jiangsu University, Zhenjiang, China
      name:Department of Immunology, Jiangsu University, Zhenjiang, China

External Links {🔗}(364)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js
Video.js

CDN Services {📦}

Crossref
Net/play">

Video Abstract

LINK . SPRINGER . COM {}