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Keywords {🔍}

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Topics {✒️}

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Questions {❓}

• Positive correlation of fecal calprotectin with serum antioxidant enzymes in patients with inflammatory bowel disease: accidental numerical correlation or a new finding?

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WebPage:
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         headline:Biodegradable MoSe2-polyvinylpyrrolidone nanoparticles with multi-enzyme activity for ameliorating acute pancreatitis
         description:Exogenous antioxidant materials mimicking endogenous antioxidant systems are commonly used for the treatment of oxidative stress-induced injuries. Thus, artificial enzymes have emerged as promising candidates for balancing and treating the dysregulation of redox homeostasis in vivo. Herein, a one-pot hydrothermal strategy for the facile preparation of MoSe2-polyvinylpyrrolidone (PVP) nanoparticles (NPs) is reported. The synthesized NPs were biodegradable due to their exposure to oxygen and exhibited high stability. Moreover, they effectively mimicked various naturally occurring enzymes (including catalase, superoxide dismutase, peroxidase, and glutathione peroxidase) and scavenged free radicals, such as 3-ethylbenzothiazoline-6-sulfonic acid, ·OH, ·O2−, and 1,1-diphenyl-2-picrylhydrazyl radical. Further apoptosis detection studies revealed that MoSe2-PVP NPs significantly increased the cell survival probability in H2O2 in a concentration-dependent manner. The cytoprotective effect of MoSe2-PVP NPs was explored for an animal model of acute pancreatitis, which confirmed its remarkable therapeutic efficacy. Owing to the biodegradable and biocompatible nature of MoSe2-PVP NPs, the findings of this work can stimulate the development of other artificial nanoenzymes for antioxidant therapies.
         datePublished:2022-03-05T00:00:00Z
         dateModified:2022-03-05T00:00:00Z
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            Biodegradable nanoparticles
            Reactive oxygen species
            Acute pancreatitis
            Nanozyme
            Biotechnology
            Nanotechnology
            Molecular Medicine
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      headline:Biodegradable MoSe2-polyvinylpyrrolidone nanoparticles with multi-enzyme activity for ameliorating acute pancreatitis
      description:Exogenous antioxidant materials mimicking endogenous antioxidant systems are commonly used for the treatment of oxidative stress-induced injuries. Thus, artificial enzymes have emerged as promising candidates for balancing and treating the dysregulation of redox homeostasis in vivo. Herein, a one-pot hydrothermal strategy for the facile preparation of MoSe2-polyvinylpyrrolidone (PVP) nanoparticles (NPs) is reported. The synthesized NPs were biodegradable due to their exposure to oxygen and exhibited high stability. Moreover, they effectively mimicked various naturally occurring enzymes (including catalase, superoxide dismutase, peroxidase, and glutathione peroxidase) and scavenged free radicals, such as 3-ethylbenzothiazoline-6-sulfonic acid, ·OH, ·O2−, and 1,1-diphenyl-2-picrylhydrazyl radical. Further apoptosis detection studies revealed that MoSe2-PVP NPs significantly increased the cell survival probability in H2O2 in a concentration-dependent manner. The cytoprotective effect of MoSe2-PVP NPs was explored for an animal model of acute pancreatitis, which confirmed its remarkable therapeutic efficacy. Owing to the biodegradable and biocompatible nature of MoSe2-PVP NPs, the findings of this work can stimulate the development of other artificial nanoenzymes for antioxidant therapies.
      datePublished:2022-03-05T00:00:00Z
      dateModified:2022-03-05T00:00:00Z
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         MoSe2-polyvinylpyrrolidone
         Biodegradable nanoparticles
         Reactive oxygen species
         Acute pancreatitis
         Nanozyme
         Biotechnology
         Nanotechnology
         Molecular Medicine
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      name:Hang Wu
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            address:
               name:Department of Chemistry, School of Materials and Chemistry, University of Shanghai for Science and Technology, Shanghai, China
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            name:Changhai Hospital, Naval Military Medical University
            address:
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      name:Department of Chemistry, School of Materials and Chemistry, University of Shanghai for Science and Technology, Shanghai, China
      name:Department of Gastroenterology, Changhai Hospital, Naval Military Medical University, Shanghai, China
      name:Department of Gastroenterology, Changhai Hospital, Naval Military Medical University, Shanghai, China
      name:Department of Gastroenterology, Changhai Hospital, Naval Military Medical University, Shanghai, China
      name:Department of Chemistry, School of Materials and Chemistry, University of Shanghai for Science and Technology, Shanghai, China
      name:Department of Gastroenterology, Changhai Hospital, Naval Military Medical University, Shanghai, China

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