We are analyzing https://link.springer.com/article/10.1186/s12943-020-01247-w.

Title:
cGAS-STING pathway in cancer biotherapy | Molecular Cancer
Description:
The activation of the cGAS-STING pathway has tremendous potential to improve anti-tumor immunity by generating type I interferons. In recent decades, we have witnessed that producing dsDNA upon various stimuli is an initiative factor, triggering the cGAS-SING pathway for a defensive host. The understanding of both intracellular cascade reaction and the changes of molecular components gains insight into type I IFNs and adaptive immunity. Based on the immunological study, the STING-cGAS pathway is coupled to cancer biotherapy. The most challenging problem is the limited therapeutic effect. Therefore, people view 5, 6-dimethylxanthenone-4-acetic acid, cyclic dinucleotides and various derivative as cGAS-STING pathway agonists. Even so, these agonists have flaws in decreasing biotherapeutic efficacy. Subsequently, we exploited agonist delivery systems (nanocarriers, microparticles and hydrogels). The article will discuss the activation of the cGAS-STING pathway and underlying mechanisms, with an introduction of cGAS-STING agonists, related clinical trials and agonist delivery systems.
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Keywords {🔍}

pubmed, cancer, google, scholar, sting, cells, cas, cgassting, pathway, cell, tumor, immune, central, type, cgamp, agonists, antitumor, delivery, tumors, immunity, activation, dna, mice, responses, system, efficacy, dmxaa, signaling, cyclic, interferon, study, agonist, innate, ifn, ifns, cgas, cdns, production, patients, biotherapy, effect, therapeutic, clinical, vaccine, httpsclinicaltrialsgovshownct, acid, immunotherapy, response, lung, drugs,

Topics {✒️}

2-distearoyl-sn-glycero-3-phosphoethanolamine-n-[methoxy low dose c-di-gmp sting adjuvant c-di-gmp cd20-targeted tetrameric interferon-alpha gov/publications/dictionaries/cancer-drug c-di-gmp slows adding c-di-gmp generating t-cell-rich tme cell-mediated anti-tumor immunity β-sheets electrostatically crosslink ifn-dependent anti-tumor effect cgamp-induced anti-tumor effect synthesize cyclic di-nucleotides fish-specific protein kinase low-dose outpatient chemobiotherapy cgas-sting pathway agonist cgas-sting pathway fights allele-specific methylation occurs cgas-sting-mediated molecular galectin-3 captures interferon-gamma sting-dependent immune response activated cgas-sting pathway tumour cell-derived microparticles brca1-deficient ovarian cancer c7-functionalized dmxaa derivatives cgas-sting signaling pathway cgas-sting pathway agonists generate anti-tumor immunity cgas-sting signaling axis c-di-gmp er-golgi intermediate compartment interferon-dependent antitumor immunity polyinosinic-polycytidylic acid adjuvant immune response-targeting neoantigens improves anti-pd-1 immunotherapy tumor cell-derived microparticles nanoparticles incorporating ifn-gamma tumour necrosis factor-α sting-mediated interferon response cell–mediated tumor killing cell-mediated tumor killing elicit anti-tumor immunity triple-negative breast cancer cancer cell-autonomous contribution present-tumor specific antigens cyclic di-gmp pd-l1-insensitive models tumor-derived cgamp triggers cgas-sting pathway challenges anti-tumor biological response

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WebPage:
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         headline:cGAS-STING pathway in cancer biotherapy
         description:The activation of the cGAS-STING pathway has tremendous potential to improve anti-tumor immunity by generating type I interferons. In recent decades, we have witnessed that producing dsDNA upon various stimuli is an initiative factor, triggering the cGAS-SING pathway for a defensive host. The understanding of both intracellular cascade reaction and the changes of molecular components gains insight into type I IFNs and adaptive immunity. Based on the immunological study, the STING-cGAS pathway is coupled to cancer biotherapy. The most challenging problem is the limited therapeutic effect. Therefore, people view 5, 6-dimethylxanthenone-4-acetic acid, cyclic dinucleotides and various derivative as cGAS-STING pathway agonists. Even so, these agonists have flaws in decreasing biotherapeutic efficacy. Subsequently, we exploited agonist delivery systems (nanocarriers, microparticles and hydrogels). The article will discuss the activation of the cGAS-STING pathway and underlying mechanisms, with an introduction of cGAS-STING agonists, related clinical trials and agonist delivery systems.
         datePublished:2020-09-04T00:00:00Z
         dateModified:2020-09-04T00:00:00Z
         pageStart:1
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            Cancer biotherapy
            Interferon
            Cyclic dinucleotide
            Agonist
            Delivery system
            Clinical trials
            Cancer Research
            Oncology
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ScholarlyArticle:
      headline:cGAS-STING pathway in cancer biotherapy
      description:The activation of the cGAS-STING pathway has tremendous potential to improve anti-tumor immunity by generating type I interferons. In recent decades, we have witnessed that producing dsDNA upon various stimuli is an initiative factor, triggering the cGAS-SING pathway for a defensive host. The understanding of both intracellular cascade reaction and the changes of molecular components gains insight into type I IFNs and adaptive immunity. Based on the immunological study, the STING-cGAS pathway is coupled to cancer biotherapy. The most challenging problem is the limited therapeutic effect. Therefore, people view 5, 6-dimethylxanthenone-4-acetic acid, cyclic dinucleotides and various derivative as cGAS-STING pathway agonists. Even so, these agonists have flaws in decreasing biotherapeutic efficacy. Subsequently, we exploited agonist delivery systems (nanocarriers, microparticles and hydrogels). The article will discuss the activation of the cGAS-STING pathway and underlying mechanisms, with an introduction of cGAS-STING agonists, related clinical trials and agonist delivery systems.
      datePublished:2020-09-04T00:00:00Z
      dateModified:2020-09-04T00:00:00Z
      pageStart:1
      pageEnd:16
      license:http://creativecommons.org/publicdomain/zero/1.0/
      sameAs:https://doi.org/10.1186/s12943-020-01247-w
      keywords:
         cGAS-STING pathway
         Cancer biotherapy
         Interferon
         Cyclic dinucleotide
         Agonist
         Delivery system
         Clinical trials
         Cancer Research
         Oncology
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      name:Laboratory of Aging Research and Cancer Drug Target, State Key Laboratory of Biotherapy, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, PR China
      name:Laboratory of Aging Research and Cancer Drug Target, State Key Laboratory of Biotherapy, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, PR China
      name:Laboratory of Aging Research and Cancer Drug Target, State Key Laboratory of Biotherapy, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, PR China
      name:Laboratory of Aging Research and Cancer Drug Target, State Key Laboratory of Biotherapy, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, PR China
      name:Laboratory of Aging Research and Cancer Drug Target, State Key Laboratory of Biotherapy, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, PR China

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