We are analyzing https://link.springer.com/article/10.1186/s12943-020-01206-5.

Title:
RETRACTED ARTICLE: LncRNA BCRT1 promotes breast cancer progression by targeting miR-1303/PTBP3 axis | Molecular Cancer
Description:
Background Long noncoding RNAs (lncRNAs) play crucial roles in tumor progression and are aberrantly expressed in various cancers. However, the functional roles of lncRNAs in breast cancer remain largely unknown. Methods Based on public databases and integrating bioinformatics analyses, the overexpression of lncRNA BCRT1 in breast cancer tissues was detected and further validated in a cohort of breast cancer tissues. The effects of lncRNA BCRT1 on proliferation, migration, invasion and macrophage polarization were determined by in vitro and in vivo experiments. Luciferase reporter assay and RNA immunoprecipitation (RIP) were carried out to reveal the interaction between lncRNA BCRT1, miR-1303, and PTBP3. Chromatin immunoprecipitation (ChIP) and RT-PCR were used to evaluate the regulatory effect of hypoxia-inducible factor-1α (HIF-1α) on lncRNA BCRT1. Results LncRNA BCRT1 was significantly upregulated in breast cancer tissues, which was correlated with poor prognosis in breast cancer patients. LncRNA BCRT1 knockdown remarkably suppressed tumor growth and metastasis in vitro and in vivo. Mechanistically, lncRNA BCRT1 could competitively bind with miR-1303 to prevent the degradation of its target gene PTBP3, which acts as a tumor-promoter in breast cancer. LncRNA BCRT1 overexpression could promote M2 polarization of macrophages, mediated by exosomes, which further accelerated breast cancer progression. Furthermore, lncRNA BCRT1 was upregulated in response to hypoxia, which was attributed to the binding of HIF-1α to HREs in the lncRNA BCRT1 promoter. Conclusions Collectively, these results reveal a novel HIF-1α/lncRNA BCRT1/miR-1303/PTBP3 pathway for breast cancer progression and suggest that lncRNA BCRT1 might be a potential biomarker and therapeutic target for breast cancer.
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Keywords {🔍}

lncrna, bcrt, cancer, breast, cells, expression, ptbp, pubmed, fig, article, mdamb, cell, overexpression, google, scholar, knockdown, cas, tumor, assay, additional, macrophages, file, hypoxia, hifα, increased, proliferation, results, lncrnas, rtpcr, exosomes, figure, progression, metastasis, migration, central, zhang, assays, rna, tissues, usa, wang, patients, control, showed, bcrtoverexpressing, significantly, revealed, analysis, transfected, markers,

Topics {✒️}

hif-1α/lncrna bcrt1/mir-1303/ptbp3 pathway lps/inf-γ-induced m1 macrophages regulating mir-4766-5p/sirt1 axis nonhsat101069/mir-129-5p/twist1 axis hif-1α-mediated transcriptional regulation lncrna brct1/mir-1303/ptbp3 axis hif-1α-dependent transcriptional regulation kaplan-meier plotter tool full size image sihif-1α-repressed emt profile real-time pcr analysis effectively sponging mir-129-5p article download pdf lncrna bcrt1-overexpressing groups driving deacetylation-dependent accumulation full-length lncrna bcrt1 hypoxia-inducible factor-1α coding rna-prlb acts hif-1α knockdown reversed breast cancer-related transcript 1 national high-level talents allowing hif-1α translocation lncrna agap2-as1 hif-1α knockdown attenuated lncrna bcrt1/mir-1303 axis suppress hypoxia-induced proliferation facilitated hypoxia-induced emt hypoxia-induced cell proliferation hif-1α knockdown inhibited il-4/il-13-induced m2 macrophages anti-tumour strategies aiming lncrna bcrt1-overexpressing group targeting mir-1303/ptbp3 axis lncrna bcrt1-overexpressing cells lncrna bcrt1-overexpressing vector 5 μl annexin v-fitc kaplan–meier analysis showed open-access database analyzing multi-omics data 100 ng/ml cholera toxin polyethylene glycol-based method dual-luciferase reporter assays nuclear/cytoplasmic rna fractionation epithelial-mesenchymal transition anti-hif-1α antibody kaplan–meier survival analysis abundant immune-related cells lncrna bcrt1-overexpressing exosomes cell cytoplasmic/nuclear fractionation lps/inf-γ

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A ceRNA hypothesis: the Rosetta stone of a hidden RNA language?

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WebPage:
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         description:Long noncoding RNAs (lncRNAs) play crucial roles in tumor progression and are aberrantly expressed in various cancers. However, the functional roles of lncRNAs in breast cancer remain largely unknown. Based on public databases and integrating bioinformatics analyses, the overexpression of lncRNA BCRT1 in breast cancer tissues was detected and further validated in a cohort of breast cancer tissues. The effects of lncRNA BCRT1 on proliferation, migration, invasion and macrophage polarization were determined by in vitro and in vivo experiments. Luciferase reporter assay and RNA immunoprecipitation (RIP) were carried out to reveal the interaction between lncRNA BCRT1, miR-1303, and PTBP3. Chromatin immunoprecipitation (ChIP) and RT-PCR were used to evaluate the regulatory effect of hypoxia-inducible factor-1α (HIF-1α) on lncRNA BCRT1. LncRNA BCRT1 was significantly upregulated in breast cancer tissues, which was correlated with poor prognosis in breast cancer patients. LncRNA BCRT1 knockdown remarkably suppressed tumor growth and metastasis in vitro and in vivo. Mechanistically, lncRNA BCRT1 could competitively bind with miR-1303 to prevent the degradation of its target gene PTBP3, which acts as a tumor-promoter in breast cancer. LncRNA BCRT1 overexpression could promote M2 polarization of macrophages, mediated by exosomes, which further accelerated breast cancer progression. Furthermore, lncRNA BCRT1 was upregulated in response to hypoxia, which was attributed to the binding of HIF-1α to HREs in the lncRNA BCRT1 promoter. Collectively, these results reveal a novel HIF-1α/lncRNA BCRT1/miR-1303/PTBP3 pathway for breast cancer progression and suggest that lncRNA BCRT1 might be a potential biomarker and therapeutic target for breast cancer.
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            miR-1303
            PTBP3
            Progression
            Breast cancer
            Cancer Research
            Oncology
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      headline:RETRACTED ARTICLE: LncRNA BCRT1 promotes breast cancer progression by targeting miR-1303/PTBP3 axis
      description:Long noncoding RNAs (lncRNAs) play crucial roles in tumor progression and are aberrantly expressed in various cancers. However, the functional roles of lncRNAs in breast cancer remain largely unknown. Based on public databases and integrating bioinformatics analyses, the overexpression of lncRNA BCRT1 in breast cancer tissues was detected and further validated in a cohort of breast cancer tissues. The effects of lncRNA BCRT1 on proliferation, migration, invasion and macrophage polarization were determined by in vitro and in vivo experiments. Luciferase reporter assay and RNA immunoprecipitation (RIP) were carried out to reveal the interaction between lncRNA BCRT1, miR-1303, and PTBP3. Chromatin immunoprecipitation (ChIP) and RT-PCR were used to evaluate the regulatory effect of hypoxia-inducible factor-1α (HIF-1α) on lncRNA BCRT1. LncRNA BCRT1 was significantly upregulated in breast cancer tissues, which was correlated with poor prognosis in breast cancer patients. LncRNA BCRT1 knockdown remarkably suppressed tumor growth and metastasis in vitro and in vivo. Mechanistically, lncRNA BCRT1 could competitively bind with miR-1303 to prevent the degradation of its target gene PTBP3, which acts as a tumor-promoter in breast cancer. LncRNA BCRT1 overexpression could promote M2 polarization of macrophages, mediated by exosomes, which further accelerated breast cancer progression. Furthermore, lncRNA BCRT1 was upregulated in response to hypoxia, which was attributed to the binding of HIF-1α to HREs in the lncRNA BCRT1 promoter. Collectively, these results reveal a novel HIF-1α/lncRNA BCRT1/miR-1303/PTBP3 pathway for breast cancer progression and suggest that lncRNA BCRT1 might be a potential biomarker and therapeutic target for breast cancer.
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         LncRNA BCRT1
         miR-1303
         PTBP3
         Progression
         Breast cancer
         Cancer Research
         Oncology
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            name:Qilu Hospital of Shandong University
            address:
               name:Pathology Tissue Bank, Qilu Hospital of Shandong University, Jinan, People’s Republic of China
               type:PostalAddress
            type:Organization
      name:Hanwen Zhang
      affiliation:
            name:Qilu Hospital of Shandong University
            address:
               name:Department of Breast Surgery, Qilu Hospital of Shandong University, Jinan, People’s Republic of China
               type:PostalAddress
            type:Organization
      name:Ying Liu
      affiliation:
            name:Qilu Hospital of Shandong University
            address:
               name:Department of Breast Surgery, Qilu Hospital of Shandong University, Jinan, People’s Republic of China
               type:PostalAddress
            type:Organization
      name:Dianwen Han
      affiliation:
            name:Qilu Hospital of Shandong University
            address:
               name:Department of Breast Surgery, Qilu Hospital of Shandong University, Jinan, People’s Republic of China
               type:PostalAddress
            type:Organization
      name:Ning Zhang
      affiliation:
            name:Qilu Hospital of Shandong University
            address:
               name:Department of Breast Surgery, Qilu Hospital of Shandong University, Jinan, People’s Republic of China
               type:PostalAddress
            type:Organization
      name:Tingting Ma
      affiliation:
            name:Qilu Hospital of Shandong University
            address:
               name:Department of Breast Surgery, Qilu Hospital of Shandong University, Jinan, People’s Republic of China
               type:PostalAddress
            type:Organization
      name:Yajie Wang
      affiliation:
            name:Qilu Hospital of Shandong University
            address:
               name:Department of Breast Surgery, Qilu Hospital of Shandong University, Jinan, People’s Republic of China
               type:PostalAddress
            type:Organization
      name:Fangzhou Ye
      affiliation:
            name:Qilu Hospital of Shandong University
            address:
               name:Department of Breast Surgery, Qilu Hospital of Shandong University, Jinan, People’s Republic of China
               type:PostalAddress
            type:Organization
      name:Dan Luo
      affiliation:
            name:Qilu Hospital of Shandong University
            address:
               name:Pathology Tissue Bank, Qilu Hospital of Shandong University, Jinan, People’s Republic of China
               type:PostalAddress
            type:Organization
      name:Xiaoyan Li
      affiliation:
            name:Qilu Hospital of Shandong University
            address:
               name:Department of Breast Surgery, Qilu Hospital of Shandong University, Jinan, People’s Republic of China
               type:PostalAddress
            type:Organization
      name:Qifeng Yang
      url:http://orcid.org/0000-0003-0576-8513
      affiliation:
            name:Qilu Hospital of Shandong University
            address:
               name:Department of Breast Surgery, Qilu Hospital of Shandong University, Jinan, People’s Republic of China
               type:PostalAddress
            type:Organization
            name:Qilu Hospital of Shandong University
            address:
               name:Pathology Tissue Bank, Qilu Hospital of Shandong University, Jinan, People’s Republic of China
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Breast Surgery, Qilu Hospital of Shandong University, Jinan, People’s Republic of China
      name:Department of Breast Surgery, Qilu Hospital of Shandong University, Jinan, People’s Republic of China
      name:Department of Breast Surgery, Qilu Hospital of Shandong University, Jinan, People’s Republic of China
      name:Pathology Tissue Bank, Qilu Hospital of Shandong University, Jinan, People’s Republic of China
      name:Pathology Tissue Bank, Qilu Hospital of Shandong University, Jinan, People’s Republic of China
      name:Pathology Tissue Bank, Qilu Hospital of Shandong University, Jinan, People’s Republic of China
      name:Department of Breast Surgery, Qilu Hospital of Shandong University, Jinan, People’s Republic of China
      name:Department of Breast Surgery, Qilu Hospital of Shandong University, Jinan, People’s Republic of China
      name:Department of Breast Surgery, Qilu Hospital of Shandong University, Jinan, People’s Republic of China
      name:Department of Breast Surgery, Qilu Hospital of Shandong University, Jinan, People’s Republic of China
      name:Department of Breast Surgery, Qilu Hospital of Shandong University, Jinan, People’s Republic of China
      name:Department of Breast Surgery, Qilu Hospital of Shandong University, Jinan, People’s Republic of China
      name:Department of Breast Surgery, Qilu Hospital of Shandong University, Jinan, People’s Republic of China
      name:Pathology Tissue Bank, Qilu Hospital of Shandong University, Jinan, People’s Republic of China
      name:Department of Breast Surgery, Qilu Hospital of Shandong University, Jinan, People’s Republic of China
      name:Department of Breast Surgery, Qilu Hospital of Shandong University, Jinan, People’s Republic of China
      name:Pathology Tissue Bank, Qilu Hospital of Shandong University, Jinan, People’s Republic of China

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