We are analyzing https://link.springer.com/article/10.1186/s12943-019-1001-7.

Title:
Exosomes in gastric cancer: roles, mechanisms, and applications | Molecular Cancer
Description:
Exosomes are nanosized extracellular vesicles that can be released by almost all types of cells. Initially considered as the garbage bins acting to discard unwanted products of cells, exosomes are now recognized as an important way for cellular communication by transmitting bioactive molecules including proteins, DNA, mRNAs, and non-coding RNAs. The recent studies have shown that exosomes are critically involved in human health and diseases including cancer. Exosomes have been suggested to participate in the promotion of tumorigenesis, tumor growth and metastasis, tumor angiogenesis, tumor immune escape, and tumor therapy resistance. Increasing evidence indicate that exosomes play important roles in gastric cancer development and progression. In this review, we summarized the current understanding of exosomes in gastric cancer with an emphasis on the biological roles of exosomes in gastric cancer and their potential as biomarkers for gastric cancer diagnosis as well as potential targets for gastric cancer therapy.
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Keywords {🔍}

exosomes, cancer, cells, gastric, article, google, scholar, exosomal, cell, cas, derived, tumor, patients, zhang, wang, proteins, metastasis, protein, plasma, expression, biomarkers, mirp, potential, serum, growth, mirnas, vesicles, including, progression, promote, demonstrated, migration, diagnostic, diagnosis, proliferation, pathway, study, peritoneal, stem, extracellular, rna, roles, therapy, resistance, early, mirna, significantly, analysis, rnas, studies,

Topics {✒️}

activating wnt/β-catenin pathway nod/scid mouse model wnt/beta-catenin pathway activate nf-κb pathway mek/erk signaling pathways induced pericyte-fibroblast transition mesenchymal-epithelial transition factor lectin-induced agglutination method p53 wild-type mbmmsc pi3k/akt signaling pathway tumour-specific ctl response inactivating pi3k/akt signaling epstein-barr virus-transformed tgf-beta/smad pathway targeting c-myb article download pdf m2 macrophages-derived exosomes activating pro-tumor phenotypes microplate-based magneto-immunocapture mesenchymal stem cells exosomal mir-27a derived exosomal mir-21-5p derived exosomal tgf-β1 level post-surgery gc patients macrophages-derived exosomes promote gastric cancer stem exosome-mediated microrna-451 redistribution c-met receptor promotes disease progression exosomal mirna profiles promote cancer progression cd9-positive exosomes derived exert tumor-inhibitory effects paclitaxel-resistant gc cells tumor exosome-mediated promotion immunoaffinity capture-based techniques gc exosome-based immunotherapy identified exosomal mir-23b including ultracentrifugation-based techniques stem cell factors heat-treated malignant ascites gastric cancer progression early-stage gastric cancer bmp pathway inhibitor gc-specific exosomal dna nf-κb pathway pylori-infected gc cells rna-based therapeutic strategies promote cancer growth serum exosomal mir-424-5p

Schema {🗺️}

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         description:Exosomes are nanosized extracellular vesicles that can be released by almost all types of cells. Initially considered as the garbage bins acting to discard unwanted products of cells, exosomes are now recognized as an important way for cellular communication by transmitting bioactive molecules including proteins, DNA, mRNAs, and non-coding RNAs. The recent studies have shown that exosomes are critically involved in human health and diseases including cancer. Exosomes have been suggested to participate in the promotion of tumorigenesis, tumor growth and metastasis, tumor angiogenesis, tumor immune escape, and tumor therapy resistance. Increasing evidence indicate that exosomes play important roles in gastric cancer development and progression. In this review, we summarized the current understanding of exosomes in gastric cancer with an emphasis on the biological roles of exosomes in gastric cancer and their potential as biomarkers for gastric cancer diagnosis as well as potential targets for gastric cancer therapy.
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      headline:Exosomes in gastric cancer: roles, mechanisms, and applications
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         Gastric cancer
         Progression
         Biomarker
         Target
         Cancer Research
         Oncology
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      name:Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, China
      name:Departmemt of Clinical Laboratory Medicine, Nantong Tumor Hospital, Nantong, China
      name:Institute of Digestive Diseases, The Affiliated People’s Hospital of Jiangsu University, Zhenjiang, China
      name:Institute of Digestive Diseases, The Affiliated People’s Hospital of Jiangsu University, Zhenjiang, China
      name:Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, China
      name:Institute of Digestive Diseases, The Affiliated People’s Hospital of Jiangsu University, Zhenjiang, China
      name:Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, China
      name:Institute of Digestive Diseases, The Affiliated People’s Hospital of Jiangsu University, Zhenjiang, China
      name:Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, China

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