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Keywords {🔍}

cancer, mira, delivery, cells, tumor, cell, expression, treatment, therapy, nanoparticles, drug, therapeutic, targeted, systems, mirnas, gene, growth, mirna, clinical, studies, potential, regulation, suppressor, biological, target, reported, apoptosis, breast, including, system, article, researchers, multiple, lung, study, gnps, signaling, microrna, role, activity, shown, viral, molecular, metastasis, observed, human, anticancer, models, deliver, nanocomposites,

Topics {✒️}

p53/mir-34a/csf1r/stat3 feedback loop pegylated-thymoquinone-nanoparticle mediated retardation pam-ap/pmir-34a nps double-negative feedback loop javad sharifi-rad chitosan nanoparticle-mediated delivery peg-pcd micelles-based hyaluronic acid-chitosan nanoparticles porous silica-based nanoparticles triggers post-natal mortality mutant p53-dependent pathway mir-34a replacement therapy intratumor mir-34a proportion mir-34a expressing plasmid nano-conjugate delivery systems regulate epithelial-mesenchymal transitions nanoparticle-based delivery system microrna-targeted gene silencing eda sönmez gürer biologically active mir-34a microrna-based cancer therapeutics polymer-based delivery system microrna mir-34a inhibits micrornas-based nano-strategies multiple drug-resistant pathogens lipid-based nanoparticle formulation ros-responsive polymeric micelles nanoparticle-based cancer drug intact p53-dependent responses p53 binding domains/sites immune-related adverse effects c-terminal regulatory domain targeted mir-34a delivery alternative p53-independent strategies mir34a-based targeted therapy rna-induced silencing complex tumor suppressor microrna-34a mir34a-mediated suppression activity cancer-targeted gene delivery liposomal mir-34a mimic snalp encapsulating mir34a �rna-binding proteins/genetics” cancer-targeted drug delivery s6 aptamer-conjugated dendrimer �cell cycle checkpoints/genetics” amphiphilic nanocarrier-induced modulation transforming growth factor-β plk1 inhibitor/mir-34a anti-tumor immune response design therapeutically-effective candidates

Questions {❓}

• Slack FJJCr: OncomiR or tumor suppressor?
• Tassone PJMt-na: Mir-34: a new weapon against cancer?

Schema {🗺️}

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         headline:Targeted therapy using nanocomposite delivery systems in cancer treatment: highlighting miR34a regulation for clinical applications
         description:The clinical application of microRNAs in modern therapeutics holds great promise to uncover molecular limitations and conquer the unbeatable castle of cancer metastasis. miRNAs play a decisive role that regulating gene expression at the post-transcription level while controlling both the stability and translation capacity of mRNAs. Specifically, miR34a is a master regulator of the tumor suppressor gene, cancer progression, stemness, and drug resistance at the cell level in p53-dependent and independent signaling. With changing, trends in nanotechnology, in particular with the revolution in the field of nanomedicine, nano drug delivery systems have emerged as a prominent strategy in clinical practices coupled with miR34a delivery. Recently, it has been observed that forced miR34a expression in human cancer cell lines and model organisms limits cell proliferation and metastasis by targeting several signaling cascades, with various studies endorsing that miR34a deregulation in cancer cells modulates apoptosis and thus requires targeted nano-delivery systems for cancer treatment. In this sense, the present review aims to provide an overview of the clinical applications of miR34a regulation in targeted therapy of cancer.
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      headline:Targeted therapy using nanocomposite delivery systems in cancer treatment: highlighting miR34a regulation for clinical applications
      description:The clinical application of microRNAs in modern therapeutics holds great promise to uncover molecular limitations and conquer the unbeatable castle of cancer metastasis. miRNAs play a decisive role that regulating gene expression at the post-transcription level while controlling both the stability and translation capacity of mRNAs. Specifically, miR34a is a master regulator of the tumor suppressor gene, cancer progression, stemness, and drug resistance at the cell level in p53-dependent and independent signaling. With changing, trends in nanotechnology, in particular with the revolution in the field of nanomedicine, nano drug delivery systems have emerged as a prominent strategy in clinical practices coupled with miR34a delivery. Recently, it has been observed that forced miR34a expression in human cancer cell lines and model organisms limits cell proliferation and metastasis by targeting several signaling cascades, with various studies endorsing that miR34a deregulation in cancer cells modulates apoptosis and thus requires targeted nano-delivery systems for cancer treatment. In this sense, the present review aims to provide an overview of the clinical applications of miR34a regulation in targeted therapy of cancer.
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      name:Javad Sharifi-Rad
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      name:Department of Microbiology, University of Balochistan Quetta, Quetta, Pakistan
      name:Department of Pathobiology, KBCMA, CVAS, Sub Campus University of Veterinary and Animal Sciences, Narowal, Pakistan
      name:National Centre of Excellence in Molecular Biology, University of the Punjab, Lahore, Pakistan
      name:Department of Zoology, University of Gujrat, Gujrat, Pakistan
      name:Dipartimento di Scienze Biomediche, Chirurgiche ed Odontoiatriche, Università degli Studi di Milano, Milan, Italy
      name:Department of Agricultural and Environmental Sciences, Università degli Studi di Milano, Milan, Italy
      name:Faculty of Pharmacy, Department of Pharmacognosy, Sivas Cumhuriyet University, Sivas, Turkey
      name:Facultad de Medicina, Universidad del Azuay, Cuenca, Ecuador
      name:Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, Craiova, Romania

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