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         headline:Long-term effect of sitagliptin on endothelial function in type 2 diabetes: a sub-analysis of the PROLOGUE study
         description:As a sub-analysis of the PROLOGUE study, we evaluated the long-term effect of sitagliptin, a dipeptidyl peptidase 4 inhibitor, on endothelial function in the conduit brachial artery in patients with type 2 diabetes. In the PROLOGUE study, patients were randomly assigned to either add-on sitagliptin treatment (sitagliptin group) or continued conventional antihyperglycemic treatment (conventional group). Among the 463 participants in the PROLOGUE study, FMD was measured in 17 patients in the sitagliptin group and 18 patients in the conventional group at the beginning and after 12 and 24 months of treatment. HbA1c levels were significantly decreased after 12 and 24 months of treatment compared to baseline values in both groups (7.0 ± 0.4 vs. 6.6 ± 0.3 and 6.6 ± 0.4 % in the sitagliptin group; 7.0 ± 0.6 vs. 6.6 ± 0.7 and 6.6 ± 0.7 % in the conventional group; P < 0.05, respectively). There was no significant difference between FMD values at baseline and after 12 and 24 months in the sitagliptin group (4.3 ± 2.6 vs. 4.4 ± 2.1 and 4.4 ± 2.3 %, P = 1.0, respectively). Although FMD had a tendency to increase from 4.3 ± 2.4 % at baseline to 5.2 ± 1.9 % after 12 months and 5.1 ± 2.2 % after 24 months in the conventional group, there was no significant difference between FMD values at baseline and after 12 and 24 months (P = 0.36 and 0.33, respectively). Add-on sitagliptin to conventional antihyperglycemic drugs in patients with type 2 diabetes did not alter endothelial function in the conduit brachial artery measured by FMD during a 2-year study period. Sitagliptin may be used without concern for an adverse effect on endothelial function in patients with type 2 diabetes. Trial registration: University hospital Medical Information Network (UMIN) Center: ID UMIN000004490
         datePublished:2016-09-13T00:00:00Z
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      headline:Long-term effect of sitagliptin on endothelial function in type 2 diabetes: a sub-analysis of the PROLOGUE study
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               name:Department of Cardiology, Hiroshima City Hospital, Hiroshima, Japan
               type:PostalAddress
            type:Organization
      name:Jun Ohno
      affiliation:
            name:Tsushima Municipal Hospital
            address:
               name:Department of Cardiology, Tsushima Municipal Hospital, Tsushima, Japan
               type:PostalAddress
            type:Organization
      name:Masato Iida
      affiliation:
            name:Mitsubishi Nagoya Hospital
            address:
               name:Department of Cardiology, Mitsubishi Nagoya Hospital, Nagoya, Japan
               type:PostalAddress
            type:Organization
      name:Hiroaki Sano
      affiliation:
            name:Nagoya Ekisaikai Hospital
            address:
               name:Department of Cardiology, Nagoya Ekisaikai Hospital, Nagoya, Japan
               type:PostalAddress
            type:Organization
      name:Hirofumi Tomiyama
      affiliation:
            name:Tokyo Medical University
            address:
               name:Department of Cardiology, Tokyo Medical University, Tokyo, Japan
               type:PostalAddress
            type:Organization
      name:Teruo Inoue
      affiliation:
            name:Dokkyo Medical University
            address:
               name:Department of Cardiovascular Medicine, Dokkyo Medical University, Shimotsuga-gun, Japan
               type:PostalAddress
            type:Organization
      name:Atsushi Tanaka
      affiliation:
            name:Saga University
            address:
               name:Department of Cardiovascular Medicine, Saga University, Saga, Japan
               type:PostalAddress
            type:Organization
      name:Toyoaki Murohara
      affiliation:
            name:Nagoya University Graduate School of Medicine
            address:
               name:Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan
               type:PostalAddress
            type:Organization
      name:Koichi Node
      affiliation:
            name:Saga University
            address:
               name:Department of Cardiovascular Medicine, Saga University, Saga, Japan
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Department of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan
      name:Division of Regeneration and Medicine, Medical Center for Translational and Clinical Research, Hiroshima University Hospital, Hiroshima, Japan
      name:Department of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan
      name:Department of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan
      name:Department of Cardiovascular Medicine, Tokushima University Hospital, Tokushima, Japan
      name:Department of Cardiovascular Medicine, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan
      name:Department of Clinical Pharmacology and Therapeutics, University of the Ryukyus, Nishihara-cho, Japan
      name:Department of Diabetes, Endocrinology, Metabolism and Rheumatology, Tokyo Medical University, Tokyo, Japan
      name:Department of Endocrinology and Metabolism, Yokohama City University, Yokohama, Japan
      name:Department of Cardiology, Hiroshima City Hospital, Hiroshima, Japan
      name:Department of Cardiology, Tsushima Municipal Hospital, Tsushima, Japan
      name:Department of Cardiology, Mitsubishi Nagoya Hospital, Nagoya, Japan
      name:Department of Cardiology, Nagoya Ekisaikai Hospital, Nagoya, Japan
      name:Department of Cardiology, Tokyo Medical University, Tokyo, Japan
      name:Department of Cardiovascular Medicine, Dokkyo Medical University, Shimotsuga-gun, Japan
      name:Department of Cardiovascular Medicine, Saga University, Saga, Japan
      name:Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan
      name:Department of Cardiovascular Medicine, Saga University, Saga, Japan

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