We are analyzing https://link.springer.com/article/10.1186/s12915-016-0262-5.

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Background Programmed cell deaths in the nematode Caenorhabditis elegans are generally considered suicides. Dying cells are engulfed by neighboring cells in a process of phagocytosis. To better understand the interaction between the engulfment and death processes, we analyzed B.al/rapaav cell death, which has been previously described as engulfment-dependent and hence as a possible murder. Results We found that B.al/rapaav is resistant to caspase-pathway activation: the caspase-mediated suicide pathway initiates the cell-death process but is insufficient to cause B.al/rapaav death without the subsequent assistance of engulfment. When the engulfing cell P12.pa is absent, other typically non-phagocytic cells can display cryptic engulfment potential and facilitate this death. Conclusions We term this death an “assisted suicide” and propose that assisted suicides likely occur in other organisms. The study of assisted suicides might provide insight into non-cell autonomous influences on cell death. Understanding the mechanism that causes B.al/rapaav to be resistant to activation of the caspase pathway might reveal the basis of differences in the sensitivity to apoptotic stimuli of tumor and normal cells, a key issue in the field of cancer therapeutics.
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Keywords {🔍}

balrapaav, cell, death, engulfment, ced, cells, animals, ppa, egl, suicide, mutants, nis, fig, pubmed, elegans, article, genes, google, scholar, celldeath, balapaav, stage, cas, larval, engulfed, barapaav, dying, programmed, process, fourth, homolog, engulfing, animal, data, pathway, xnlsgfp, undead, caenorhabditis, evl, required, horvitz, deaths, additional, mcherryph, wildtype, hime, assisted, file, expressed, expression,

Topics {✒️}

mid-fourth larval stage article download pdf orca-er ccd camera short pro-apoptotic isoform regulates cell-death genes post-embryonic cell lineages fourth larval stage cell-death mutant backgrounds average background intensity core cell-death pathway elegans act cell-autonomously anti-apoptotic gene ced-9 al/rapaav death failing cell-death process requires al/rapaav death requires al/rapaav cell continued endogenous cell-death genes genes function cell-autonomously pro-apoptotic genes ced-3 pro-apoptotic genes egl-1 regulate cell death engulfment-defective double mutant phagocyte-dependent cell deaths cell-death suicide genes al/rapaav exhibited morphological cell-killing activity independent cell-death suicide pathway al/rapaav cell membranes al/rapaav cell death al/rapaav death occurs cell-killing activities independent elegans search search caspase-mediated suicide pathway privacy choices/manage cookies al/rapaav death process caenorhabditis elegans male cell-death genes egl-1 anti-cd47 antibodies programmed cell death larval stage animals al/rapaav cell corpse al/rapaav homolog survives engulfment-mediated cell deaths purified digestion products independent apoptotic pathways al/rapaav cytoplasmic refractility al/rapaav cell fated creative commons license wild-type male developing male tail

Questions {❓}

Are there other assisted suicides?
Do assisted suicides exist in other species?
How might engulfment promote the death process?
Al/rapaav require assistance by an engulfing cell to die?

Schema {🗺️}

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