We are analyzing https://link.springer.com/article/10.1186/s12903-023-03179-5.

Title:
Causal association between body mass index and temporomandibular disorders: a bidirectional two-sample Mendelian randomization analysis | BMC Oral Health
Description:
Background Observational studies have shown that body mass index (BMI) is highly correlated with the occurrence of temporomandibular disorders (TMDs). However, these studies failed to present a causal relationship. Thus, we aimed to performed a Mendelian randomization (MR) study to investigate causality between BMI and TMDs. Methods We performed a two-sample bidirectional MR analysis using large-scale genome-wide association studies (GWAS). Data were obtained from a large-scale BMI dataset (N = 322,154), TMDs dataset (N = 134,280). The causal effects were estimated with inverse-variance weighted (IVW) method, MR Egger, weighted median. Sensitivity analyses were implemented with Cochran’s Q test, MR-Egger intercept test, MR-PRESSO, leave-one-out analysis and the funnel plot. Results In the forward MR analysis, a genetic prediction of low BMI was causally associated with a higher risk of TMDs (IVW OR: 0.575, 95% CI: 0.415–0.798, p: 0.001). Similar results were obtained using other complementary methods (MR Egger OR: 0.270, 95% CI: 0.104–0.698, p: 0.009; weighted median OR: 0.496, 95% CI: 0.298–0.826, p: 0.007). In the reverse MR results, TMDs was shown to have no significant effect on BMI (all p > 0.05). No pleiotropy and heterogeneity were detected in the bidirectional analysis (p > 0.05). Conclusion A lower BMI might be causally associated with increased risk of TMDs, supporting the importance of weight control for the prevention of TMDs. Clinicians should pay more attention to the low-BMI patients among those seeking medical advice due to temporomandibular joint discomfort.
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Keywords {🔍}

tmds, bmi, article, temporomandibular, pubmed, study, google, scholar, causal, disorders, analysis, association, data, obesity, mendelian, genetic, risk, snps, randomization, studies, body, joint, table, supplementary, oral, mass, pain, central, index, factors, variants, exposure, research, relationship, methods, results, effect, pleiotropy, patients, outcome, material, health, weighted, method, egger, fig, bidirectional, chen, gwas, effects,

Topics {✒️}

including inverse-variance weighted genome-wide association studies inverse-variance weighted large-scale observational studies electronic supplementary material single nucleotide polymorphisms cranio-maxillo-facial surgery age-dependent body constitution large sample size article download pdf mendelian randomization analysis mendelian randomization studies mendelian randomization study community-based twin registry full access publishing summary data doctor-diagnosed tmds data large-scale bmi dataset gender-stratified gwas data oral mucosal diseases body mass index privacy choices/manage cookies high fat diet phenoscanner search supplementary material mr-egger intercept test central taiwan public health dent randomized controlled trials temporomandibular joint disorders korea national health estimated effects derived bone health revisited mr research support mr effect size bone mineral research enhancing muscle mass additional ethics statement forward mr analysis seeking medical advice mendelian randomization investigating causal relationships cross-sectional studies temporomandibular joint discomfort oxygen-ozone therapy [1] creative commons licence bone mineral density residual pleiotropic effects genetic variants related temporomandibular joint disorder

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         description:Observational studies have shown that body mass index (BMI) is highly correlated with the occurrence of temporomandibular disorders (TMDs). However, these studies failed to present a causal relationship. Thus, we aimed to performed a Mendelian randomization (MR) study to investigate causality between BMI and TMDs. We performed a two-sample bidirectional MR analysis using large-scale genome-wide association studies (GWAS). Data were obtained from a large-scale BMI dataset (N = 322,154), TMDs dataset (N = 134,280). The causal effects were estimated with inverse-variance weighted (IVW) method, MR Egger, weighted median. Sensitivity analyses were implemented with Cochran’s Q test, MR-Egger intercept test, MR-PRESSO, leave-one-out analysis and the funnel plot. In the forward MR analysis, a genetic prediction of low BMI was causally associated with a higher risk of TMDs (IVW OR: 0.575, 95% CI: 0.415–0.798, p: 0.001). Similar results were obtained using other complementary methods (MR Egger OR: 0.270, 95% CI: 0.104–0.698, p: 0.009; weighted median OR: 0.496, 95% CI: 0.298–0.826, p: 0.007). In the reverse MR results, TMDs was shown to have no significant effect on BMI (all p > 0.05). No pleiotropy and heterogeneity were detected in the bidirectional analysis (p > 0.05). A lower BMI might be causally associated with increased risk of TMDs, supporting the importance of weight control for the prevention of TMDs. Clinicians should pay more attention to the low-BMI patients among those seeking medical advice due to temporomandibular joint discomfort.
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      description:Observational studies have shown that body mass index (BMI) is highly correlated with the occurrence of temporomandibular disorders (TMDs). However, these studies failed to present a causal relationship. Thus, we aimed to performed a Mendelian randomization (MR) study to investigate causality between BMI and TMDs. We performed a two-sample bidirectional MR analysis using large-scale genome-wide association studies (GWAS). Data were obtained from a large-scale BMI dataset (N = 322,154), TMDs dataset (N = 134,280). The causal effects were estimated with inverse-variance weighted (IVW) method, MR Egger, weighted median. Sensitivity analyses were implemented with Cochran’s Q test, MR-Egger intercept test, MR-PRESSO, leave-one-out analysis and the funnel plot. In the forward MR analysis, a genetic prediction of low BMI was causally associated with a higher risk of TMDs (IVW OR: 0.575, 95% CI: 0.415–0.798, p: 0.001). Similar results were obtained using other complementary methods (MR Egger OR: 0.270, 95% CI: 0.104–0.698, p: 0.009; weighted median OR: 0.496, 95% CI: 0.298–0.826, p: 0.007). In the reverse MR results, TMDs was shown to have no significant effect on BMI (all p > 0.05). No pleiotropy and heterogeneity were detected in the bidirectional analysis (p > 0.05). A lower BMI might be causally associated with increased risk of TMDs, supporting the importance of weight control for the prevention of TMDs. Clinicians should pay more attention to the low-BMI patients among those seeking medical advice due to temporomandibular joint discomfort.
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