We are analyzing https://link.springer.com/article/10.1186/s12885-022-09972-9.

Title:
Machine learning for the micropeptide encoded by LINC02381 regulates ferroptosis through the glucose transporter SLC2A10 in glioblastoma | BMC Cancer
Description:
Glioblastoma (GBM) is the most common primary intracranial tumor in the central nervous system, and resistance to temozolomide is an important reason for the failure of GBM treatment. We screened out that Solute Carrier Family 2 Member 10 (SLC2A10) is significantly highly expressed in GBM with a poor prognosis, which is also enriched in the NF-E2 p45-related factor 2 (NRF2) signalling pathway. The NRF2 signalling pathway is an important defence mechanism against ferroptosis. SLC2A10 related LINC02381 is highly expressed in GBM, which is localized in the cytoplasm/exosomes, and LINC02381 encoded micropeptides are localized in the exosomes. The micropeptide encoded by LINC02381 may be a potential treatment strategy for GBM, but the underlying mechanism of its function is not precise yet. We put forward the hypothesis: “The micropeptide encoded by LINC02381 regulates ferroptosis through the glucose transporter SLC2A10 in GBM.” This study innovatively used machine learning for micropeptide to provide personalized diagnosis and treatment plans for precise treatment of GBM, thereby promoting the development of translational medicine. The study aimed to help find new disease diagnoses and prognostic biomarkers and provide a new strategy for experimental scientists to design the downstream validation experiments.
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28 years and 1 months (reg. 1997-05-29).

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Keywords {🔍}

gbm, pubmed, article, linc, slca, google, scholar, analysis, ferroptosis, encoded, central, sweets, micropeptides, fig, cas, expression, glioblastoma, expressed, nrf, cancer, micropeptide, jiang, tumor, significantly, potential, cell, pathway, survival, data, found, highly, pancancer, tumors, function, research, glucose, signalling, transporter, family, prognosis, prognostic, role, functional, desweets, cerna, information, learning, prediction, transporters, enrichment,

Topics {✒️}

linc02381/hsa-mir-27a-3p/slc2a10 axis linc02381/hsa-mir-27a-3p/slc2a10 circ-akt3 encoded akt3-174aa circrna-coded micropeptide akt3-174aa mir-34a primary transcription icgc/tcga pan-cancer analysis tyrosine kinase src/yes1 hmg-box family establishes article download pdf active phosphoinositide-dependent kinase-1 pubmed literature search sweets protein–protein interaction sugar-phosphate/phosphate exchanger large-scale expression profiling mir-34a pri-mirna �slc-mediated transmembrane transport” org/gsea/msigdb/search tumor-suppressor microprotein encoded anti-tumor medicinal plants central nervous system map genome-wide data high-grade gliomas mitochondrial metabolism-related genes poorly prognostic de-sweets sorf-encoded peptides targeted ddit4/slc2a3 signal writing–review & editing privacy choices/manage cookies functional enrichment analyses full access potential clinical applications lactic acid products functional enrichment analysis public database tcga akt3-174aa plays regulate cell proliferation conduct enrichment analysis mri derived radiomics article jiang mapk signalling pathway significantly lower levels nrf2 signalling pathway including gene clusters exosomal noncoding rnas high-dimensional embedding subcellular position prediction nrf2 signal pathway creative commons licence significantly high expression physically relevant concentrations

Schema {🗺️}

WebPage:
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         headline:Machine learning for the micropeptide encoded by LINC02381 regulates ferroptosis through the glucose transporter SLC2A10 in glioblastoma
         description:Glioblastoma (GBM) is the most common primary intracranial tumor in the central nervous system, and resistance to temozolomide is an important reason for the failure of GBM treatment. We screened out that Solute Carrier Family 2 Member 10 (SLC2A10) is significantly highly expressed in GBM with a poor prognosis, which is also enriched in the NF-E2 p45-related factor 2 (NRF2) signalling pathway. The NRF2 signalling pathway is an important defence mechanism against ferroptosis. SLC2A10 related LINC02381 is highly expressed in GBM, which is localized in the cytoplasm/exosomes, and LINC02381 encoded micropeptides are localized in the exosomes. The micropeptide encoded by LINC02381 may be a potential treatment strategy for GBM, but the underlying mechanism of its function is not precise yet. We put forward the hypothesis: “The micropeptide encoded by LINC02381 regulates ferroptosis through the glucose transporter SLC2A10 in GBM.” This study innovatively used machine learning for micropeptide to provide personalized diagnosis and treatment plans for precise treatment of GBM, thereby promoting the development of translational medicine. The study aimed to help find new disease diagnoses and prognostic biomarkers and provide a new strategy for experimental scientists to design the downstream validation experiments.
         datePublished:2022-08-12T00:00:00Z
         dateModified:2022-08-12T00:00:00Z
         pageStart:1
         pageEnd:11
         license:http://creativecommons.org/publicdomain/zero/1.0/
         sameAs:https://doi.org/10.1186/s12885-022-09972-9
         keywords:
            Micropeptide
            Glioblastoma
            SLC2A10
            LINC02381
            NRF2
            Cancer Research
            Oncology
            Surgical Oncology
            Health Promotion and Disease Prevention
            Biomedicine
            general
            Medicine/Public Health
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            issn:
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                        type:PostalAddress
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                     address:
                        name:Anhui Provincial Clinical Research Center for Critical Respiratory Disease, Wuhu, China
                        type:PostalAddress
                     type:Organization
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               affiliation:
                     name:Wannan Medical College
                     address:
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                        type:PostalAddress
                     type:Organization
               type:Person
               name:Qiancheng Xu
               affiliation:
                     name:Anhui Provincial Clinical Research Center for Critical Respiratory Disease
                     address:
                        name:Anhui Provincial Clinical Research Center for Critical Respiratory Disease, Wuhu, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Kun Lv
               affiliation:
                     name:Yijishan Hospital of Wannan Medical College
                     address:
                        name:Key Laboratory of Non-Coding RNA Transformation Research of Anhui Higher Education Institution, Yijishan Hospital of Wannan Medical College, Wuhu, China
                        type:PostalAddress
                     type:Organization
                     name:Yijishan Hospital of Wannan Medical College
                     address:
                        name:Central Laboratory, Yijishan Hospital of Wannan Medical College, Wuhu, China
                        type:PostalAddress
                     type:Organization
                     name:Anhui Provincial Clinical Research Center for Critical Respiratory Disease
                     address:
                        name:Anhui Provincial Clinical Research Center for Critical Respiratory Disease, Wuhu, China
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Yunpeng Cao
               affiliation:
                     name:Chinese Academy of Sciences
                     address:
                        name:Wuhan Botanical Garden, Chinese Academy of Sciences, Wuhan, China
                        type:PostalAddress
                     type:Organization
               email:[email protected]
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ScholarlyArticle:
      headline:Machine learning for the micropeptide encoded by LINC02381 regulates ferroptosis through the glucose transporter SLC2A10 in glioblastoma
      description:Glioblastoma (GBM) is the most common primary intracranial tumor in the central nervous system, and resistance to temozolomide is an important reason for the failure of GBM treatment. We screened out that Solute Carrier Family 2 Member 10 (SLC2A10) is significantly highly expressed in GBM with a poor prognosis, which is also enriched in the NF-E2 p45-related factor 2 (NRF2) signalling pathway. The NRF2 signalling pathway is an important defence mechanism against ferroptosis. SLC2A10 related LINC02381 is highly expressed in GBM, which is localized in the cytoplasm/exosomes, and LINC02381 encoded micropeptides are localized in the exosomes. The micropeptide encoded by LINC02381 may be a potential treatment strategy for GBM, but the underlying mechanism of its function is not precise yet. We put forward the hypothesis: “The micropeptide encoded by LINC02381 regulates ferroptosis through the glucose transporter SLC2A10 in GBM.” This study innovatively used machine learning for micropeptide to provide personalized diagnosis and treatment plans for precise treatment of GBM, thereby promoting the development of translational medicine. The study aimed to help find new disease diagnoses and prognostic biomarkers and provide a new strategy for experimental scientists to design the downstream validation experiments.
      datePublished:2022-08-12T00:00:00Z
      dateModified:2022-08-12T00:00:00Z
      pageStart:1
      pageEnd:11
      license:http://creativecommons.org/publicdomain/zero/1.0/
      sameAs:https://doi.org/10.1186/s12885-022-09972-9
      keywords:
         Micropeptide
         Glioblastoma
         SLC2A10
         LINC02381
         NRF2
         Cancer Research
         Oncology
         Surgical Oncology
         Health Promotion and Disease Prevention
         Biomedicine
         general
         Medicine/Public Health
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         issn:
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         volumeNumber:22
         type:
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         name:BioMed Central
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Lan Jiang
            affiliation:
                  name:Yijishan Hospital of Wannan Medical College
                  address:
                     name:Key Laboratory of Non-Coding RNA Transformation Research of Anhui Higher Education Institution, Yijishan Hospital of Wannan Medical College, Wuhu, China
                     type:PostalAddress
                  type:Organization
                  name:Yijishan Hospital of Wannan Medical College
                  address:
                     name:Central Laboratory, Yijishan Hospital of Wannan Medical College, Wuhu, China
                     type:PostalAddress
                  type:Organization
                  name:Anhui Provincial Clinical Research Center for Critical Respiratory Disease
                  address:
                     name:Anhui Provincial Clinical Research Center for Critical Respiratory Disease, Wuhu, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jianke Yang
            affiliation:
                  name:Wannan Medical College
                  address:
                     name:School of Preclinical Medicine, Wannan Medical College, Wuhu, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Qiancheng Xu
            affiliation:
                  name:Anhui Provincial Clinical Research Center for Critical Respiratory Disease
                  address:
                     name:Anhui Provincial Clinical Research Center for Critical Respiratory Disease, Wuhu, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Kun Lv
            affiliation:
                  name:Yijishan Hospital of Wannan Medical College
                  address:
                     name:Key Laboratory of Non-Coding RNA Transformation Research of Anhui Higher Education Institution, Yijishan Hospital of Wannan Medical College, Wuhu, China
                     type:PostalAddress
                  type:Organization
                  name:Yijishan Hospital of Wannan Medical College
                  address:
                     name:Central Laboratory, Yijishan Hospital of Wannan Medical College, Wuhu, China
                     type:PostalAddress
                  type:Organization
                  name:Anhui Provincial Clinical Research Center for Critical Respiratory Disease
                  address:
                     name:Anhui Provincial Clinical Research Center for Critical Respiratory Disease, Wuhu, China
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Yunpeng Cao
            affiliation:
                  name:Chinese Academy of Sciences
                  address:
                     name:Wuhan Botanical Garden, Chinese Academy of Sciences, Wuhan, China
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
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      name:Yijishan Hospital of Wannan Medical College
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      name:Yijishan Hospital of Wannan Medical College
      address:
         name:Central Laboratory, Yijishan Hospital of Wannan Medical College, Wuhu, China
         type:PostalAddress
      name:Anhui Provincial Clinical Research Center for Critical Respiratory Disease
      address:
         name:Anhui Provincial Clinical Research Center for Critical Respiratory Disease, Wuhu, China
         type:PostalAddress
      name:Wannan Medical College
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         name:School of Preclinical Medicine, Wannan Medical College, Wuhu, China
         type:PostalAddress
      name:Anhui Provincial Clinical Research Center for Critical Respiratory Disease
      address:
         name:Anhui Provincial Clinical Research Center for Critical Respiratory Disease, Wuhu, China
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      address:
         name:Key Laboratory of Non-Coding RNA Transformation Research of Anhui Higher Education Institution, Yijishan Hospital of Wannan Medical College, Wuhu, China
         type:PostalAddress
      name:Yijishan Hospital of Wannan Medical College
      address:
         name:Central Laboratory, Yijishan Hospital of Wannan Medical College, Wuhu, China
         type:PostalAddress
      name:Anhui Provincial Clinical Research Center for Critical Respiratory Disease
      address:
         name:Anhui Provincial Clinical Research Center for Critical Respiratory Disease, Wuhu, China
         type:PostalAddress
      name:Chinese Academy of Sciences
      address:
         name:Wuhan Botanical Garden, Chinese Academy of Sciences, Wuhan, China
         type:PostalAddress
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      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Lan Jiang
      affiliation:
            name:Yijishan Hospital of Wannan Medical College
            address:
               name:Key Laboratory of Non-Coding RNA Transformation Research of Anhui Higher Education Institution, Yijishan Hospital of Wannan Medical College, Wuhu, China
               type:PostalAddress
            type:Organization
            name:Yijishan Hospital of Wannan Medical College
            address:
               name:Central Laboratory, Yijishan Hospital of Wannan Medical College, Wuhu, China
               type:PostalAddress
            type:Organization
            name:Anhui Provincial Clinical Research Center for Critical Respiratory Disease
            address:
               name:Anhui Provincial Clinical Research Center for Critical Respiratory Disease, Wuhu, China
               type:PostalAddress
            type:Organization
      name:Jianke Yang
      affiliation:
            name:Wannan Medical College
            address:
               name:School of Preclinical Medicine, Wannan Medical College, Wuhu, China
               type:PostalAddress
            type:Organization
      name:Qiancheng Xu
      affiliation:
            name:Anhui Provincial Clinical Research Center for Critical Respiratory Disease
            address:
               name:Anhui Provincial Clinical Research Center for Critical Respiratory Disease, Wuhu, China
               type:PostalAddress
            type:Organization
      name:Kun Lv
      affiliation:
            name:Yijishan Hospital of Wannan Medical College
            address:
               name:Key Laboratory of Non-Coding RNA Transformation Research of Anhui Higher Education Institution, Yijishan Hospital of Wannan Medical College, Wuhu, China
               type:PostalAddress
            type:Organization
            name:Yijishan Hospital of Wannan Medical College
            address:
               name:Central Laboratory, Yijishan Hospital of Wannan Medical College, Wuhu, China
               type:PostalAddress
            type:Organization
            name:Anhui Provincial Clinical Research Center for Critical Respiratory Disease
            address:
               name:Anhui Provincial Clinical Research Center for Critical Respiratory Disease, Wuhu, China
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Yunpeng Cao
      affiliation:
            name:Chinese Academy of Sciences
            address:
               name:Wuhan Botanical Garden, Chinese Academy of Sciences, Wuhan, China
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Key Laboratory of Non-Coding RNA Transformation Research of Anhui Higher Education Institution, Yijishan Hospital of Wannan Medical College, Wuhu, China
      name:Central Laboratory, Yijishan Hospital of Wannan Medical College, Wuhu, China
      name:Anhui Provincial Clinical Research Center for Critical Respiratory Disease, Wuhu, China
      name:School of Preclinical Medicine, Wannan Medical College, Wuhu, China
      name:Anhui Provincial Clinical Research Center for Critical Respiratory Disease, Wuhu, China
      name:Key Laboratory of Non-Coding RNA Transformation Research of Anhui Higher Education Institution, Yijishan Hospital of Wannan Medical College, Wuhu, China
      name:Central Laboratory, Yijishan Hospital of Wannan Medical College, Wuhu, China
      name:Anhui Provincial Clinical Research Center for Critical Respiratory Disease, Wuhu, China
      name:Wuhan Botanical Garden, Chinese Academy of Sciences, Wuhan, China

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