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LINK . SPRINGER . COM {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Link.springer.com Make Money
  6. Keywords
  7. Topics
  8. Questions
  9. Schema
  10. External Links
  11. Analytics And Tracking
  12. Libraries

We are analyzing https://link.springer.com/article/10.1186/s12868-016-0284-5.

Title:
Col1a1+ perivascular cells in the brain are a source of retinoic acid following stroke | BMC Neuroscience
Description:
Background Perivascular stromal cells (PSCs) are a recently identified cell type that comprises a small percentage of the platelet derived growth factor receptor-β+ cells within the CNS perivascular space. PSCs are activated following injury to the brain or spinal cord, expand in number and contribute to fibrotic scar formation within the injury site. Beyond fibrosis, their high density in the lesion core makes them a potential significant source of signals that act on neural cells adjacent to the lesion site. Results Our developmental analysis of PSCs, defined by expression of Collagen1a1 in the maturing brain, revealed that PSCs first appear postnatally and may originate from the meninges. PSCs express many of the same markers as meningeal fibroblasts, including expression of the retinoic acid (RA) synthesis proteins Raldh1 and Raldh2. Using a focal brain ischemia injury model to induce PSC activation and expansion, we show a substantial increase in Raldh1+/Raldh2+ PSCs and Raldh1+ activated macrophages in the lesion core. We find that RA levels are significantly elevated in the ischemic hemisphere and induce signaling in astrocytes and neurons in the peri-infarct region. Conclusions This study highlights a dual role for activated, non-neural cells where PSCs deposit fibrotic ECM proteins and, along with macrophages, act as a potentially important source of RA, a potent signaling molecule that could influence recovery events in a neuroprotective fashion following brain injury.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

  • Science
  • Education
  • Health & Fitness

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
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How Does Link.springer.com Make Money? {💸}

We can't figure out the monetization strategy.

Many websites are intended to earn money, but some serve to share ideas or build connections. Websites exist for all kinds of purposes. This might be one of them. Link.springer.com might be earning cash quietly, but we haven't detected the monetization method.

Keywords {🔍}

pscs, brain, cells, raldh, fig, cola, pubmed, article, google, scholar, injury, lesion, cas, arrows, cell, stroke, meningeal, expressed, carets, ischemic, hemisphere, expression, meninges, perivascular, acid, retinoic, scar, core, postnatal, vessels, green, analysis, signaling, macrophages, tissue, mouse, red, cns, express, number, mcao, central, spinal, cord, synthesis, blood, pdgfrα, crabp, fibrotic, psc,

Topics {✒️}

rare-hsp68-lacz transgene activity β-gal+/pdgfrβ-negative cell bodies rare-lacz transgene activity rare-hsp26-lacz/+ maintained rare-lacz reporter gene article download pdf alexafluor 633-conjugated isolectin-b4 stromal progenitors full size image transforming growth factor-beta2 rare-hsp68-lacz liquid–liquid extraction method low-amplitude eeg activity chicken anti-β-galactosidase 1 possibly β-galactosidase+ astrocyte central nervous system astrocyte-meningeal fibroblast interactions col1a1-gfp transgenic line anschutz medical campus fast lc-mrm3 quantification adult microglial cells rabbit anti-β-galactosidase 1 scale bars 2 mm alexafluor-conjugated secondary antibodies couptf1+/raldh2-negative cells pdgfrβ-expressing perivascular cells overlapping β-gal expression ischemia-induced cerebral injury scale bars 20 µm post-natal time point neural cells adjacent internal carotid artery pdgfrα+/crabp2-negative cells neural tissue continued tile-scan image related subjects retinoic acid synthesis retinoic acid-synthesizing trans-retinoic acid astrocyte marker gfap flush cellular debris local cellular response age-related failure neun+/β-gal+ neurons privacy choices/manage cookies retinoic acid homeostasis gfap+/β-gal+ astrocytes retinoic acid signaling post-natal brain synthesis proteins raldh1

Questions {❓}

  • New therapeutic target for CNS injury?

Schema {🗺️}

WebPage:
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         headline:Col1a1+ perivascular cells in the brain are a source of retinoic acid following stroke
         description:Perivascular stromal cells (PSCs) are a recently identified cell type that comprises a small percentage of the platelet derived growth factor receptor-β+ cells within the CNS perivascular space. PSCs are activated following injury to the brain or spinal cord, expand in number and contribute to fibrotic scar formation within the injury site. Beyond fibrosis, their high density in the lesion core makes them a potential significant source of signals that act on neural cells adjacent to the lesion site. Our developmental analysis of PSCs, defined by expression of Collagen1a1 in the maturing brain, revealed that PSCs first appear postnatally and may originate from the meninges. PSCs express many of the same markers as meningeal fibroblasts, including expression of the retinoic acid (RA) synthesis proteins Raldh1 and Raldh2. Using a focal brain ischemia injury model to induce PSC activation and expansion, we show a substantial increase in Raldh1+/Raldh2+ PSCs and Raldh1+ activated macrophages in the lesion core. We find that RA levels are significantly elevated in the ischemic hemisphere and induce signaling in astrocytes and neurons in the peri-infarct region. This study highlights a dual role for activated, non-neural cells where PSCs deposit fibrotic ECM proteins and, along with macrophages, act as a potentially important source of RA, a potent signaling molecule that could influence recovery events in a neuroprotective fashion following brain injury.
         datePublished:2016-07-15T00:00:00Z
         dateModified:2016-07-15T00:00:00Z
         pageStart:1
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         sameAs:https://doi.org/10.1186/s12868-016-0284-5
         keywords:
            Pericyte
            Perivascular stromal cell
            Retinoic acid
            Stroke
            Brain fibrosis
            Meninges
            Neurosciences
            Neurobiology
            Animal Models
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                     address:
                        name:Department of Pediatrics, Section of Developmental Biology, University of Colorado Denver-Anschutz Medical Campus, Aurora, USA
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ScholarlyArticle:
      headline:Col1a1+ perivascular cells in the brain are a source of retinoic acid following stroke
      description:Perivascular stromal cells (PSCs) are a recently identified cell type that comprises a small percentage of the platelet derived growth factor receptor-β+ cells within the CNS perivascular space. PSCs are activated following injury to the brain or spinal cord, expand in number and contribute to fibrotic scar formation within the injury site. Beyond fibrosis, their high density in the lesion core makes them a potential significant source of signals that act on neural cells adjacent to the lesion site. Our developmental analysis of PSCs, defined by expression of Collagen1a1 in the maturing brain, revealed that PSCs first appear postnatally and may originate from the meninges. PSCs express many of the same markers as meningeal fibroblasts, including expression of the retinoic acid (RA) synthesis proteins Raldh1 and Raldh2. Using a focal brain ischemia injury model to induce PSC activation and expansion, we show a substantial increase in Raldh1+/Raldh2+ PSCs and Raldh1+ activated macrophages in the lesion core. We find that RA levels are significantly elevated in the ischemic hemisphere and induce signaling in astrocytes and neurons in the peri-infarct region. This study highlights a dual role for activated, non-neural cells where PSCs deposit fibrotic ECM proteins and, along with macrophages, act as a potentially important source of RA, a potent signaling molecule that could influence recovery events in a neuroprotective fashion following brain injury.
      datePublished:2016-07-15T00:00:00Z
      dateModified:2016-07-15T00:00:00Z
      pageStart:1
      pageEnd:14
      license:http://creativecommons.org/publicdomain/zero/1.0/
      sameAs:https://doi.org/10.1186/s12868-016-0284-5
      keywords:
         Pericyte
         Perivascular stromal cell
         Retinoic acid
         Stroke
         Brain fibrosis
         Meninges
         Neurosciences
         Neurobiology
         Animal Models
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         name:BioMed Central
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            name:Kathleen K. Kelly
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                     type:PostalAddress
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            type:Person
            name:Amber M. MacPherson
            affiliation:
                  name:University of Colorado Denver-Anschutz Medical Campus
                  address:
                     name:Department of Pediatrics, Section of Developmental Biology, University of Colorado Denver-Anschutz Medical Campus, Aurora, USA
                     type:PostalAddress
                  type:Organization
            type:Person
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                  name:University of Colorado Denver-Anschutz Medical Campus
                  address:
                     name:Department of Anesthesiology, University of Colorado Denver-Anschutz Medical Campus, Aurora, USA
                     type:PostalAddress
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            name:Frank Strnad
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                  name:University of Colorado Denver-Anschutz Medical Campus
                  address:
                     name:Department of Anesthesiology, University of Colorado Denver-Anschutz Medical Campus, Aurora, USA
                     type:PostalAddress
                  type:Organization
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            name:Jace W. Jones
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                  name:University of Maryland, Baltimore School of Pharmacy
                  address:
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                     type:PostalAddress
                  type:Organization
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            name:Jianshi Yu
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            name:Maureen A. Kane
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                     type:PostalAddress
                  type:Organization
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            name:Paco S. Herson
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                  name:University of Colorado Denver-Anschutz Medical Campus
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                     type:PostalAddress
                  type:Organization
                  name:University of Colorado Denver-Anschutz Medical Campus
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            name:Julie A. Siegenthaler
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      affiliation:
            name:University of Colorado Denver-Anschutz Medical Campus
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      name:Himmat Grewal
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            name:University of Colorado Denver-Anschutz Medical Campus
            address:
               name:Department of Anesthesiology, University of Colorado Denver-Anschutz Medical Campus, Aurora, USA
               type:PostalAddress
            type:Organization
      name:Frank Strnad
      affiliation:
            name:University of Colorado Denver-Anschutz Medical Campus
            address:
               name:Department of Anesthesiology, University of Colorado Denver-Anschutz Medical Campus, Aurora, USA
               type:PostalAddress
            type:Organization
      name:Jace W. Jones
      affiliation:
            name:University of Maryland, Baltimore School of Pharmacy
            address:
               name:Department of Pharmaceutical Sciences, University of Maryland, Baltimore School of Pharmacy, Baltimore, USA
               type:PostalAddress
            type:Organization
      name:Jianshi Yu
      affiliation:
            name:University of Maryland, Baltimore School of Pharmacy
            address:
               name:Department of Pharmaceutical Sciences, University of Maryland, Baltimore School of Pharmacy, Baltimore, USA
               type:PostalAddress
            type:Organization
      name:Keely Pierzchalski
      affiliation:
            name:University of Maryland, Baltimore School of Pharmacy
            address:
               name:Department of Pharmaceutical Sciences, University of Maryland, Baltimore School of Pharmacy, Baltimore, USA
               type:PostalAddress
            type:Organization
      name:Maureen A. Kane
      affiliation:
            name:University of Maryland, Baltimore School of Pharmacy
            address:
               name:Department of Pharmaceutical Sciences, University of Maryland, Baltimore School of Pharmacy, Baltimore, USA
               type:PostalAddress
            type:Organization
      name:Paco S. Herson
      affiliation:
            name:University of Colorado Denver-Anschutz Medical Campus
            address:
               name:Department of Anesthesiology, University of Colorado Denver-Anschutz Medical Campus, Aurora, USA
               type:PostalAddress
            type:Organization
            name:University of Colorado Denver-Anschutz Medical Campus
            address:
               name:Department of Pharmacology, University of Colorado Denver-Anschutz Medical Campus, Aurora, USA
               type:PostalAddress
            type:Organization
            name:University of Colorado Denver-Anschutz Medical Campus
            address:
               name:Neuronal Injury Program, University of Colorado Denver-Anschutz Medical Campus, Aurora, USA
               type:PostalAddress
            type:Organization
      name:Julie A. Siegenthaler
      affiliation:
            name:University of Colorado Denver-Anschutz Medical Campus
            address:
               name:Department of Pediatrics, Section of Developmental Biology, University of Colorado Denver-Anschutz Medical Campus, Aurora, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Pediatrics, Section of Developmental Biology, University of Colorado Denver-Anschutz Medical Campus, Aurora, USA
      name:Department of Pediatrics, Section of Developmental Biology, University of Colorado Denver-Anschutz Medical Campus, Aurora, USA
      name:Department of Anesthesiology, University of Colorado Denver-Anschutz Medical Campus, Aurora, USA
      name:Department of Anesthesiology, University of Colorado Denver-Anschutz Medical Campus, Aurora, USA
      name:Department of Pharmaceutical Sciences, University of Maryland, Baltimore School of Pharmacy, Baltimore, USA
      name:Department of Pharmaceutical Sciences, University of Maryland, Baltimore School of Pharmacy, Baltimore, USA
      name:Department of Pharmaceutical Sciences, University of Maryland, Baltimore School of Pharmacy, Baltimore, USA
      name:Department of Pharmaceutical Sciences, University of Maryland, Baltimore School of Pharmacy, Baltimore, USA
      name:Department of Anesthesiology, University of Colorado Denver-Anschutz Medical Campus, Aurora, USA
      name:Department of Pharmacology, University of Colorado Denver-Anschutz Medical Campus, Aurora, USA
      name:Neuronal Injury Program, University of Colorado Denver-Anschutz Medical Campus, Aurora, USA
      name:Department of Pediatrics, Section of Developmental Biology, University of Colorado Denver-Anschutz Medical Campus, Aurora, USA

External Links {🔗}(210)

Analytics and Tracking {📊}

  • Google Tag Manager

Libraries {📚}

  • Clipboard.js
  • Prism.js

5.68s.