We are analyzing https://link.springer.com/article/10.1186/s12864-017-4193-5.

Title:
Physical activity in the prevention of human diseases: role of epigenetic modifications | BMC Genomics
Description:
Epigenetic modification refers to heritable changes in gene function that cannot be explained by alterations in the DNA sequence. The current literature clearly demonstrates that the epigenetic response is highly dynamic and influenced by different biological and environmental factors such as aging, nutrient availability and physical exercise. As such, it is well accepted that physical activity and exercise can modulate gene expression through epigenetic alternations although the type and duration of exercise eliciting specific epigenetic effects that can result in health benefits and prevent chronic diseases remains to be determined. This review highlights the most significant findings from epigenetic studies involving physical activity/exercise interventions known to benefit chronic diseases such as metabolic syndrome, diabetes, cancer, cardiovascular and neurodegenerative diseases.
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Keywords {🔍}

pubmed, article, google, scholar, exercise, methylation, epigenetic, cas, dna, cancer, human, diseases, physical, expression, genes, training, studies, central, gene, histone, activity, effects, patients, modifications, cardiovascular, cell, muscle, cpg, disease, specific, metabolic, epigenetics, factor, involved, levels, mirnas, global, sci, factors, study, risk, skeletal, related, cells, mechanisms, breast, authors, type, heart, found,

Topics {✒️}

guan wang yannis pitsiladis brain-derived neurotrophic factor calcium channel-related gene integrated epigenomic-transcriptome networks n-terminal tail protruding beltran valls mr multi-omic microarray analysis inhibiting tumor proto-oncogene �healthier” methylation profile borderline/contradictory findings summarized glucose-stimulated insulin secretion including x-chromosome inactivation article download pdf global methylation profiles tissue-tissue cross-talk [25] int/iris/bitstream/10665/44399/1/9789241599979_eng high-intensity interval training author information authors gene-specific promoter methylation reduced fatty-acid synthesis genome-wide dna demethylation athlome project consortium mmp-related cardiovascular alteration post-diagnosis physical activity pro-bdnf protein content promoting chromatin modification /articles/supplements/volume-18-supplement-8 peripheral mononuclear cells gene-specific dna hypomethylation protein-coding genes moderate-intensity aerobic training transcriptionally silence genes methylation profile chromosomal instability correlates jumonji c-domain exercise-related epigenetic modulations privacy choices/manage cookies small rna molecules c57bl/6j male mice author correspondence original author di luigi sanchis-gomar randomised clinical trial specific sequences localised epigenetic profile aberrant methylation patterns wistar rats submitted putative key factor

Questions {❓}

Cancer genetics and epigenetics: two sides of the same coin?

Schema {🗺️}

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         headline:Physical activity in the prevention of human diseases: role of epigenetic modifications
         description:Epigenetic modification refers to heritable changes in gene function that cannot be explained by alterations in the DNA sequence. The current literature clearly demonstrates that the epigenetic response is highly dynamic and influenced by different biological and environmental factors such as aging, nutrient availability and physical exercise. As such, it is well accepted that physical activity and exercise can modulate gene expression through epigenetic alternations although the type and duration of exercise eliciting specific epigenetic effects that can result in health benefits and prevent chronic diseases remains to be determined. This review highlights the most significant findings from epigenetic studies involving physical activity/exercise interventions known to benefit chronic diseases such as metabolic syndrome, diabetes, cancer, cardiovascular and neurodegenerative diseases.
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            Life Sciences
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            Microbial Genetics and Genomics
            Plant Genetics and Genomics
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      headline:Physical activity in the prevention of human diseases: role of epigenetic modifications
      description:Epigenetic modification refers to heritable changes in gene function that cannot be explained by alterations in the DNA sequence. The current literature clearly demonstrates that the epigenetic response is highly dynamic and influenced by different biological and environmental factors such as aging, nutrient availability and physical exercise. As such, it is well accepted that physical activity and exercise can modulate gene expression through epigenetic alternations although the type and duration of exercise eliciting specific epigenetic effects that can result in health benefits and prevent chronic diseases remains to be determined. This review highlights the most significant findings from epigenetic studies involving physical activity/exercise interventions known to benefit chronic diseases such as metabolic syndrome, diabetes, cancer, cardiovascular and neurodegenerative diseases.
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         DNA methylation
         Histone modification
         Exercise
         Disease prevention
         Life Sciences
         general
         Microarrays
         Proteomics
         Animal Genetics and Genomics
         Microbial Genetics and Genomics
         Plant Genetics and Genomics
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      name:Department of Movement, Human and Health Sciences, Unit of Biology, Genetics and Biochemistry, University of Rome “Foro Italico”, Rome, Italy
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      name:Department of Movement, Human and Health Sciences, Unit of Endocrinology, University of Rome “Foro Italico”, Rome, Italy
      name:Department of Movement, Human and Health Sciences, Unit of Biology, Genetics and Biochemistry, University of Rome “Foro Italico”, Rome, Italy

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