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  1. Analyzed Page
  2. Matching Content Categories
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We are analyzing https://link.springer.com/article/10.1186/s12864-016-3230-0.

Title:
Insights into the human mesenchymal stromal/stem cell identity through integrative transcriptomic profiling | BMC Genomics
Description:
Background Mesenchymal Stromal/Stem Cells (MSCs), isolated under the criteria established by the ISCT, still have a poorly characterized phenotype that is difficult to distinguish from similar cell populations. Although the field of transcriptomics and functional genomics has quickly grown in the last decade, a deep comparative analysis of human MSCs expression profiles in a meaningful cellular context has not been yet performed. There is also a need to find a well-defined MSCs gene-signature because many recent biomedical studies show that key cellular interaction processes (i.e. inmuno-modulation, cellular cross-talk, cellular maintenance, differentiation, epithelial-mesenchymal transition) are dependent on the mesenchymal stem cells within the stromal niche. Results In this work we define a core mesenchymal lineage signature of 489 genes based on a deep comparative analysis of multiple transcriptomic expression data series that comprise: (i) MSCs of different tissue origins; (ii) MSCs in different states of commitment; (iii) other related non-mesenchymal human cell types. The work integrates several public datasets, as well as de-novo produced microarray and RNA-Seq datasets. The results present tissue-specific signatures for adipose tissue, chorionic placenta, and bone marrow MSCs, as well as for dermal fibroblasts; providing a better definition of the relationship between fibroblasts and MSCs. Finally, novel CD marker patterns and cytokine-receptor profiles are unravelled, especially for BM-MSCs; with MCAM (CD146) revealed as a prevalent marker in this subtype of MSCs. Conclusions The improved biomolecular characterization and the released genome-wide expression signatures of human MSCs provide a comprehensive new resource that can drive further functional studies and redesigned cell therapy applications.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {šŸ“š}

  • Science
  • Education
  • Telecommunications

Content Management System {šŸ“}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {šŸ“ˆ}

What is the average monthly size of link.springer.com audience?

šŸŒ  Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 7,626,432 visitors per month in the current month.

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How Does Link.springer.com Make Money? {šŸ’ø}

We don't see any clear sign of profit-making.

Some websites aren't about earning revenue; they're built to connect communities or raise awareness. There are numerous motivations behind creating websites. This might be one of them. Link.springer.com might be plotting its profit, but the way they're doing it isn't detectable yet.

Keywords {šŸ”}

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Topics {āœ’ļø}

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Schema {šŸ—ŗļø}

WebPage:
      mainEntity:
         headline:Insights into the human mesenchymal stromal/stem cell identity through integrative transcriptomic profiling
         description:Mesenchymal Stromal/Stem Cells (MSCs), isolated under the criteria established by the ISCT, still have a poorly characterized phenotype that is difficult to distinguish from similar cell populations. Although the field of transcriptomics and functional genomics has quickly grown in the last decade, a deep comparative analysis of human MSCs expression profiles in a meaningful cellular context has not been yet performed. There is also a need to find a well-defined MSCs gene-signature because many recent biomedical studies show that key cellular interaction processes (i.e. inmuno-modulation, cellular cross-talk, cellular maintenance, differentiation, epithelial-mesenchymal transition) are dependent on the mesenchymal stem cells within the stromal niche. In this work we define a core mesenchymal lineage signature of 489 genes based on a deep comparative analysis of multiple transcriptomic expression data series that comprise: (i) MSCs of different tissue origins; (ii) MSCs in different states of commitment; (iii) other related non-mesenchymal human cell types. The work integrates several public datasets, as well as de-novo produced microarray and RNA-Seq datasets. The results present tissue-specific signatures for adipose tissue, chorionic placenta, and bone marrow MSCs, as well as for dermal fibroblasts; providing a better definition of the relationship between fibroblasts and MSCs. Finally, novel CD marker patterns and cytokine-receptor profiles are unravelled, especially for BM-MSCs; with MCAM (CD146) revealed as a prevalent marker in this subtype of MSCs. The improved biomolecular characterization and the released genome-wide expression signatures of human MSCs provide a comprehensive new resource that can drive further functional studies and redesigned cell therapy applications.
         datePublished:2016-11-21T00:00:00Z
         dateModified:2016-11-21T00:00:00Z
         pageStart:1
         pageEnd:27
         license:http://creativecommons.org/publicdomain/zero/1.0/
         sameAs:https://doi.org/10.1186/s12864-016-3230-0
         keywords:
            Stromal cells
            Mesenchymal stem cells
            Placenta
            Bone marrow
            Adipose tissue
            Human gene expression
            Bioinformatic meta-analysis
            Cytokines
            CD marker
            Life Sciences
            general
            Microarrays
            Proteomics
            Animal Genetics and Genomics
            Microbial Genetics and Genomics
            Plant Genetics and Genomics
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            name:BMC Genomics
            issn:
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            name:BioMed Central
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         author:
               name:Beatriz Roson-Burgo
               affiliation:
                     name:Cancer Research Center (IBMCC, CSIC/USAL) and IBSAL, Consejo Superior de Investigaciones Cientificas (CSIC)
                     address:
                        name:Bioinformatics and Functional Genomics Group, Cancer Research Center (IBMCC, CSIC/USAL) and IBSAL, Consejo Superior de Investigaciones Cientificas (CSIC), Salamanca, Spain
                        type:PostalAddress
                     type:Organization
                     name:IBSAL-Hospital Universitario de Salamanca
                     address:
                        name:Hematology Department, IBSAL-Hospital Universitario de Salamanca, Salamanca, Spain
                        type:PostalAddress
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                     name:Centro en Red de Medicina Regenerativa y Terapia Celular de Castilla y LeĆ³n
                     address:
                        name:Centro en Red de Medicina Regenerativa y Terapia Celular de Castilla y LeĆ³n, Salamanca, Spain
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Fermin Sanchez-Guijo
               affiliation:
                     name:IBSAL-Hospital Universitario de Salamanca
                     address:
                        name:Hematology Department, IBSAL-Hospital Universitario de Salamanca, Salamanca, Spain
                        type:PostalAddress
                     type:Organization
                     name:Centro en Red de Medicina Regenerativa y Terapia Celular de Castilla y LeĆ³n
                     address:
                        name:Centro en Red de Medicina Regenerativa y Terapia Celular de Castilla y LeĆ³n, Salamanca, Spain
                        type:PostalAddress
                     type:Organization
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               name:Consuelo Del CaƱizo
               affiliation:
                     name:IBSAL-Hospital Universitario de Salamanca
                     address:
                        name:Hematology Department, IBSAL-Hospital Universitario de Salamanca, Salamanca, Spain
                        type:PostalAddress
                     type:Organization
                     name:Centro en Red de Medicina Regenerativa y Terapia Celular de Castilla y LeĆ³n
                     address:
                        name:Centro en Red de Medicina Regenerativa y Terapia Celular de Castilla y LeĆ³n, Salamanca, Spain
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Javier De Las Rivas
               affiliation:
                     name:Cancer Research Center (IBMCC, CSIC/USAL) and IBSAL, Consejo Superior de Investigaciones Cientificas (CSIC)
                     address:
                        name:Bioinformatics and Functional Genomics Group, Cancer Research Center (IBMCC, CSIC/USAL) and IBSAL, Consejo Superior de Investigaciones Cientificas (CSIC), Salamanca, Spain
                        type:PostalAddress
                     type:Organization
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ScholarlyArticle:
      headline:Insights into the human mesenchymal stromal/stem cell identity through integrative transcriptomic profiling
      description:Mesenchymal Stromal/Stem Cells (MSCs), isolated under the criteria established by the ISCT, still have a poorly characterized phenotype that is difficult to distinguish from similar cell populations. Although the field of transcriptomics and functional genomics has quickly grown in the last decade, a deep comparative analysis of human MSCs expression profiles in a meaningful cellular context has not been yet performed. There is also a need to find a well-defined MSCs gene-signature because many recent biomedical studies show that key cellular interaction processes (i.e. inmuno-modulation, cellular cross-talk, cellular maintenance, differentiation, epithelial-mesenchymal transition) are dependent on the mesenchymal stem cells within the stromal niche. In this work we define a core mesenchymal lineage signature of 489 genes based on a deep comparative analysis of multiple transcriptomic expression data series that comprise: (i) MSCs of different tissue origins; (ii) MSCs in different states of commitment; (iii) other related non-mesenchymal human cell types. The work integrates several public datasets, as well as de-novo produced microarray and RNA-Seq datasets. The results present tissue-specific signatures for adipose tissue, chorionic placenta, and bone marrow MSCs, as well as for dermal fibroblasts; providing a better definition of the relationship between fibroblasts and MSCs. Finally, novel CD marker patterns and cytokine-receptor profiles are unravelled, especially for BM-MSCs; with MCAM (CD146) revealed as a prevalent marker in this subtype of MSCs. The improved biomolecular characterization and the released genome-wide expression signatures of human MSCs provide a comprehensive new resource that can drive further functional studies and redesigned cell therapy applications.
      datePublished:2016-11-21T00:00:00Z
      dateModified:2016-11-21T00:00:00Z
      pageStart:1
      pageEnd:27
      license:http://creativecommons.org/publicdomain/zero/1.0/
      sameAs:https://doi.org/10.1186/s12864-016-3230-0
      keywords:
         Stromal cells
         Mesenchymal stem cells
         Placenta
         Bone marrow
         Adipose tissue
         Human gene expression
         Bioinformatic meta-analysis
         Cytokines
         CD marker
         Life Sciences
         general
         Microarrays
         Proteomics
         Animal Genetics and Genomics
         Microbial Genetics and Genomics
         Plant Genetics and Genomics
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12864-016-3230-0/MediaObjects/12864_2016_3230_Fig1_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12864-016-3230-0/MediaObjects/12864_2016_3230_Fig2_HTML.gif
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      isPartOf:
         name:BMC Genomics
         issn:
            1471-2164
         volumeNumber:17
         type:
            Periodical
            PublicationVolume
      publisher:
         name:BioMed Central
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Beatriz Roson-Burgo
            affiliation:
                  name:Cancer Research Center (IBMCC, CSIC/USAL) and IBSAL, Consejo Superior de Investigaciones Cientificas (CSIC)
                  address:
                     name:Bioinformatics and Functional Genomics Group, Cancer Research Center (IBMCC, CSIC/USAL) and IBSAL, Consejo Superior de Investigaciones Cientificas (CSIC), Salamanca, Spain
                     type:PostalAddress
                  type:Organization
                  name:IBSAL-Hospital Universitario de Salamanca
                  address:
                     name:Hematology Department, IBSAL-Hospital Universitario de Salamanca, Salamanca, Spain
                     type:PostalAddress
                  type:Organization
                  name:Centro en Red de Medicina Regenerativa y Terapia Celular de Castilla y LeĆ³n
                  address:
                     name:Centro en Red de Medicina Regenerativa y Terapia Celular de Castilla y LeĆ³n, Salamanca, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Fermin Sanchez-Guijo
            affiliation:
                  name:IBSAL-Hospital Universitario de Salamanca
                  address:
                     name:Hematology Department, IBSAL-Hospital Universitario de Salamanca, Salamanca, Spain
                     type:PostalAddress
                  type:Organization
                  name:Centro en Red de Medicina Regenerativa y Terapia Celular de Castilla y LeĆ³n
                  address:
                     name:Centro en Red de Medicina Regenerativa y Terapia Celular de Castilla y LeĆ³n, Salamanca, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Consuelo Del CaƱizo
            affiliation:
                  name:IBSAL-Hospital Universitario de Salamanca
                  address:
                     name:Hematology Department, IBSAL-Hospital Universitario de Salamanca, Salamanca, Spain
                     type:PostalAddress
                  type:Organization
                  name:Centro en Red de Medicina Regenerativa y Terapia Celular de Castilla y LeĆ³n
                  address:
                     name:Centro en Red de Medicina Regenerativa y Terapia Celular de Castilla y LeĆ³n, Salamanca, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Javier De Las Rivas
            affiliation:
                  name:Cancer Research Center (IBMCC, CSIC/USAL) and IBSAL, Consejo Superior de Investigaciones Cientificas (CSIC)
                  address:
                     name:Bioinformatics and Functional Genomics Group, Cancer Research Center (IBMCC, CSIC/USAL) and IBSAL, Consejo Superior de Investigaciones Cientificas (CSIC), Salamanca, Spain
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:1
["Periodical","PublicationVolume"]:
      name:BMC Genomics
      issn:
         1471-2164
      volumeNumber:17
Organization:
      name:BioMed Central
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Cancer Research Center (IBMCC, CSIC/USAL) and IBSAL, Consejo Superior de Investigaciones Cientificas (CSIC)
      address:
         name:Bioinformatics and Functional Genomics Group, Cancer Research Center (IBMCC, CSIC/USAL) and IBSAL, Consejo Superior de Investigaciones Cientificas (CSIC), Salamanca, Spain
         type:PostalAddress
      name:IBSAL-Hospital Universitario de Salamanca
      address:
         name:Hematology Department, IBSAL-Hospital Universitario de Salamanca, Salamanca, Spain
         type:PostalAddress
      name:Centro en Red de Medicina Regenerativa y Terapia Celular de Castilla y LeĆ³n
      address:
         name:Centro en Red de Medicina Regenerativa y Terapia Celular de Castilla y LeĆ³n, Salamanca, Spain
         type:PostalAddress
      name:IBSAL-Hospital Universitario de Salamanca
      address:
         name:Hematology Department, IBSAL-Hospital Universitario de Salamanca, Salamanca, Spain
         type:PostalAddress
      name:Centro en Red de Medicina Regenerativa y Terapia Celular de Castilla y LeĆ³n
      address:
         name:Centro en Red de Medicina Regenerativa y Terapia Celular de Castilla y LeĆ³n, Salamanca, Spain
         type:PostalAddress
      name:IBSAL-Hospital Universitario de Salamanca
      address:
         name:Hematology Department, IBSAL-Hospital Universitario de Salamanca, Salamanca, Spain
         type:PostalAddress
      name:Centro en Red de Medicina Regenerativa y Terapia Celular de Castilla y LeĆ³n
      address:
         name:Centro en Red de Medicina Regenerativa y Terapia Celular de Castilla y LeĆ³n, Salamanca, Spain
         type:PostalAddress
      name:Cancer Research Center (IBMCC, CSIC/USAL) and IBSAL, Consejo Superior de Investigaciones Cientificas (CSIC)
      address:
         name:Bioinformatics and Functional Genomics Group, Cancer Research Center (IBMCC, CSIC/USAL) and IBSAL, Consejo Superior de Investigaciones Cientificas (CSIC), Salamanca, Spain
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Beatriz Roson-Burgo
      affiliation:
            name:Cancer Research Center (IBMCC, CSIC/USAL) and IBSAL, Consejo Superior de Investigaciones Cientificas (CSIC)
            address:
               name:Bioinformatics and Functional Genomics Group, Cancer Research Center (IBMCC, CSIC/USAL) and IBSAL, Consejo Superior de Investigaciones Cientificas (CSIC), Salamanca, Spain
               type:PostalAddress
            type:Organization
            name:IBSAL-Hospital Universitario de Salamanca
            address:
               name:Hematology Department, IBSAL-Hospital Universitario de Salamanca, Salamanca, Spain
               type:PostalAddress
            type:Organization
            name:Centro en Red de Medicina Regenerativa y Terapia Celular de Castilla y LeĆ³n
            address:
               name:Centro en Red de Medicina Regenerativa y Terapia Celular de Castilla y LeĆ³n, Salamanca, Spain
               type:PostalAddress
            type:Organization
      name:Fermin Sanchez-Guijo
      affiliation:
            name:IBSAL-Hospital Universitario de Salamanca
            address:
               name:Hematology Department, IBSAL-Hospital Universitario de Salamanca, Salamanca, Spain
               type:PostalAddress
            type:Organization
            name:Centro en Red de Medicina Regenerativa y Terapia Celular de Castilla y LeĆ³n
            address:
               name:Centro en Red de Medicina Regenerativa y Terapia Celular de Castilla y LeĆ³n, Salamanca, Spain
               type:PostalAddress
            type:Organization
      name:Consuelo Del CaƱizo
      affiliation:
            name:IBSAL-Hospital Universitario de Salamanca
            address:
               name:Hematology Department, IBSAL-Hospital Universitario de Salamanca, Salamanca, Spain
               type:PostalAddress
            type:Organization
            name:Centro en Red de Medicina Regenerativa y Terapia Celular de Castilla y LeĆ³n
            address:
               name:Centro en Red de Medicina Regenerativa y Terapia Celular de Castilla y LeĆ³n, Salamanca, Spain
               type:PostalAddress
            type:Organization
      name:Javier De Las Rivas
      affiliation:
            name:Cancer Research Center (IBMCC, CSIC/USAL) and IBSAL, Consejo Superior de Investigaciones Cientificas (CSIC)
            address:
               name:Bioinformatics and Functional Genomics Group, Cancer Research Center (IBMCC, CSIC/USAL) and IBSAL, Consejo Superior de Investigaciones Cientificas (CSIC), Salamanca, Spain
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Bioinformatics and Functional Genomics Group, Cancer Research Center (IBMCC, CSIC/USAL) and IBSAL, Consejo Superior de Investigaciones Cientificas (CSIC), Salamanca, Spain
      name:Hematology Department, IBSAL-Hospital Universitario de Salamanca, Salamanca, Spain
      name:Centro en Red de Medicina Regenerativa y Terapia Celular de Castilla y LeĆ³n, Salamanca, Spain
      name:Hematology Department, IBSAL-Hospital Universitario de Salamanca, Salamanca, Spain
      name:Centro en Red de Medicina Regenerativa y Terapia Celular de Castilla y LeĆ³n, Salamanca, Spain
      name:Hematology Department, IBSAL-Hospital Universitario de Salamanca, Salamanca, Spain
      name:Centro en Red de Medicina Regenerativa y Terapia Celular de Castilla y LeĆ³n, Salamanca, Spain
      name:Bioinformatics and Functional Genomics Group, Cancer Research Center (IBMCC, CSIC/USAL) and IBSAL, Consejo Superior de Investigaciones Cientificas (CSIC), Salamanca, Spain

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