We are analyzing https://link.springer.com/article/10.1186/gb4184.

Title:
Cyclin-dependent kinases | Genome Biology
Description:
Cyclin-dependent kinases (CDKs) are protein kinases characterized by needing a separate subunit - a cyclin - that provides domains essential for enzymatic activity. CDKs play important roles in the control of cell division and modulate transcription in response to several extra- and intracellular cues. The evolutionary expansion of the CDK family in mammals led to the division of CDKs into three cell-cycle-related subfamilies (Cdk1, Cdk4 and Cdk5) and five transcriptional subfamilies (Cdk7, Cdk8, Cdk9, Cdk11 and Cdk20). Unlike the prototypical Cdc28 kinase of budding yeast, most of these CDKs bind one or a few cyclins, consistent with functional specialization during evolution. This review summarizes how, although CDKs are traditionally separated into cell-cycle or transcriptional CDKs, these activities are frequently combined in many family members. Not surprisingly, deregulation of this family of proteins is a hallmark of several diseases, including cancer, and drug-targeted inhibition of specific members has generated very encouraging results in clinical trials.
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Keywords {🔍}

cdk, pubmed, cdks, article, cell, google, scholar, cyclin, kinase, cas, transcription, kinases, cyclins, cyclindependent, cycle, protein, yeast, central, figure, phosphorylation, family, complex, activity, proteins, cancer, multiple, activation, biol, transcriptional, cellcycle, domain, ctd, control, members, regulation, factor, subfamilies, mammalian, cak, malumbres, cellcyclerelated, gene, required, activated, binding, rnapii, function, group, major, cells,

Topics {✒️}

consensus sequence tyr-ser-pro-thr-ser-pro-ser phospho-acceptor ser/thr region proline-directed serine/threonine-protein kinases additional arg/ser-rich motifs dual-specificity tyrosine-regulated kinase including n-ethylmaleimide-sensitive factor nf-kappab-dependent gene expression major cell-cycle-related kinases multi-tasking p-tefb complex cyclin-dependent kinase pitslre/cdk11 med4 mediator subunits multi-subunit mediator complex yeast cell-cycle-related cdks cell-cycle-related kinases article download pdf cell cycle-related kinase cell factor-dependent hepatocarcinogenesis modulate cell-cycle-promoting activity cell-cycle-dependent manner cyclin-y-related kinases cyclin-y-dependent recruitment separate cell-cycle-related cyclin-dependent protein kinases cell-cycle-related subfamilies cdk1-related b-type cdks cyclin-dependent kinases suggest wnt-β-catenin pathway mitogen-activated protein kinases preventing cell-cycle progression cell-cycle-related cdks mammalian cyclin-dependent kinases regulates beta-catenin activity adding gene-specific layers cell-cycle-related group full size image glycine-rich inhibitory element amino-terminal myristoylation motif carboxy-terminal extensions involved transcriptional cyclin-dependent kinases cyclin-dependent kinase biochemical pivotal transcription/repair factor cyclin-y-wnt pathway intrinsic cdk-activating kinase plant specific cyclin-dependent kinase inhibition increased ets2-dependent transcription serine/threonine kinases cyclin-dependent kinase control cyclin-dependent kinase regulation undergone lineage-specific expansion

Questions {❓}

Boutros R, Lobjois V, Ducommun B: CDC25 phosphatases in cancer cells: key players?

Schema {🗺️}

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         headline:Cyclin-dependent kinases
         description:Cyclin-dependent kinases (CDKs) are protein kinases characterized by needing a separate subunit - a cyclin - that provides domains essential for enzymatic activity. CDKs play important roles in the control of cell division and modulate transcription in response to several extra- and intracellular cues. The evolutionary expansion of the CDK family in mammals led to the division of CDKs into three cell-cycle-related subfamilies (Cdk1, Cdk4 and Cdk5) and five transcriptional subfamilies (Cdk7, Cdk8, Cdk9, Cdk11 and Cdk20). Unlike the prototypical Cdc28 kinase of budding yeast, most of these CDKs bind one or a few cyclins, consistent with functional specialization during evolution. This review summarizes how, although CDKs are traditionally separated into cell-cycle or transcriptional CDKs, these activities are frequently combined in many family members. Not surprisingly, deregulation of this family of proteins is a hallmark of several diseases, including cancer, and drug-targeted inhibition of specific members has generated very encouraging results in clinical trials.
         datePublished:2014-06-30T00:00:00Z
         dateModified:2014-06-30T00:00:00Z
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            Mediator Complex
            Cdk8 Module
            Cdk5 Subfamily
            Med4 Mediator Subunit
            Animal Genetics and Genomics
            Human Genetics
            Plant Genetics and Genomics
            Microbial Genetics and Genomics
            Bioinformatics
            Evolutionary Biology
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      headline:Cyclin-dependent kinases
      description:Cyclin-dependent kinases (CDKs) are protein kinases characterized by needing a separate subunit - a cyclin - that provides domains essential for enzymatic activity. CDKs play important roles in the control of cell division and modulate transcription in response to several extra- and intracellular cues. The evolutionary expansion of the CDK family in mammals led to the division of CDKs into three cell-cycle-related subfamilies (Cdk1, Cdk4 and Cdk5) and five transcriptional subfamilies (Cdk7, Cdk8, Cdk9, Cdk11 and Cdk20). Unlike the prototypical Cdc28 kinase of budding yeast, most of these CDKs bind one or a few cyclins, consistent with functional specialization during evolution. This review summarizes how, although CDKs are traditionally separated into cell-cycle or transcriptional CDKs, these activities are frequently combined in many family members. Not surprisingly, deregulation of this family of proteins is a hallmark of several diseases, including cancer, and drug-targeted inhibition of specific members has generated very encouraging results in clinical trials.
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      dateModified:2014-06-30T00:00:00Z
      pageStart:1
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      sameAs:https://doi.org/10.1186/gb4184
      keywords:
         Activation Segment
         Mediator Complex
         Cdk8 Module
         Cdk5 Subfamily
         Med4 Mediator Subunit
         Animal Genetics and Genomics
         Human Genetics
         Plant Genetics and Genomics
         Microbial Genetics and Genomics
         Bioinformatics
         Evolutionary Biology
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