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Title:
Systematic bioinformatic analysis of expression levels of 17,330 human genes across 9,783 samples from 175 types of healthy and pathological tissues | Genome Biology
Description:
Our knowledge on tissue- and disease-specific functions of human genes is rather limited and highly context-specific. Here, we have developed a method for the comparison of mRNA expression levels of most human genes across 9,783 Affymetrix gene expression array experiments representing 43 normal human tissue types, 68 cancer types, and 64 other diseases. This database of gene expression patterns in normal human tissues and pathological conditions covers 113 million datapoints and is available from the GeneSapiens website.
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Keywords {🔍}
expression, data, gene, pubmed, genes, samples, array, article, google, scholar, tissues, cancer, cas, human, generations, normalization, additional, figure, file, analysis, tissue, values, agc, types, genesapiens, central, database, healthy, normal, profiles, sample, microarray, generation, profile, method, files, biological, type, methods, affymetrix, disease, distribution, clustering, malignant, based, correlations, cell, levels, system, clusters,
Topics {✒️}
cyclic redundancy checks integrated view matthias nees body-wide expression profile author correspondence article number r139 array-generation-based gene centering body-wide expression profiles sami kilpinen body-wide expression map short-term risk stratification genome-wide expression patterns providing body-wide overviews disease-wide expression profiles article download pdf disease-specific expression profiles cell cycle-maintaining proteins systematic bioinformatic analysis outlier expression profile article kilpinen rikshospitalet-radiumhospitalet medical centre assess low-level processing shows heart-specific expression full size image central nervous system genesapiens expression profile integrating probe-level expression highly testis-specific gene multi-dimensional scaling term pre-processing refers tissue-specific genes matched disease-specific gene functions aforementioned tumor types extremely tissue-specific genes gene expression profiling integrated data-mining platform genesapiens profile demonstrated critically important feature gene ontology consortium tissue-specific marker genes cancer gene profiles low-dimensional space sysbio research program generate expression profiles affymetrix microarray experiments gene expression profiles authors’ original file privacy choices/manage cookies genome-wide discovery rhodes dr
Questions {❓}
- Jarvinen AK, Hautaniemi S, Edgren H, Auvinen P, Saarela J, Kallioniemi OP, Monni O: Are data from different gene expression microarray platforms comparable?
- Seo J, Hoffman EP: Probe set algorithms: is there a rational best bet?
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Malignant Peripheral Nerve Sheath Tumor
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Cyclic Redundancy Check
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Human Genetics
Plant Genetics and Genomics
Microbial Genetics and Genomics
Bioinformatics
Evolutionary Biology
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name:Medical Biotechnology, VTT Technical Research Centre and University of Turku, Turku, Finland
type:PostalAddress
type:Organization
name:University of Helsinki
address:
name:Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland
type:PostalAddress
type:Organization
name:Maija Wolf
affiliation:
name:VTT Technical Research Centre and University of Turku
address:
name:Medical Biotechnology, VTT Technical Research Centre and University of Turku, Turku, Finland
type:PostalAddress
type:Organization
name:University of Helsinki
address:
name:Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland
type:PostalAddress
type:Organization
name:Jaakko Astola
affiliation:
name:Tampere University of Technology
address:
name:Department of Signal Processing, Tampere University of Technology, Tampere, Finland
type:PostalAddress
type:Organization
name:Matthias Nees
affiliation:
name:VTT Technical Research Centre and University of Turku
address:
name:Medical Biotechnology, VTT Technical Research Centre and University of Turku, Turku, Finland
type:PostalAddress
type:Organization
name:Sampsa Hautaniemi
affiliation:
name:Institute of Biomedicine and Genome-Scale Biology Research Program, University of Helsinki
address:
name:Computational Systems Biology Laboratory, Institute of Biomedicine and Genome-Scale Biology Research Program, University of Helsinki, Finland
type:PostalAddress
type:Organization
name:Olli Kallioniemi
affiliation:
name:VTT Technical Research Centre and University of Turku
address:
name:Medical Biotechnology, VTT Technical Research Centre and University of Turku, Turku, Finland
type:PostalAddress
type:Organization
name:University of Helsinki
address:
name:Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland
type:PostalAddress
type:Organization
email:[email protected]
PostalAddress:
name:Medical Biotechnology, VTT Technical Research Centre and University of Turku, Turku, Finland
name:Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland
name:Department of Signal Processing, Tampere University of Technology, Tampere, Finland
name:Medical Biotechnology, VTT Technical Research Centre and University of Turku, Turku, Finland
name:Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland
name:Medical Biotechnology, VTT Technical Research Centre and University of Turku, Turku, Finland
name:Medical Biotechnology, VTT Technical Research Centre and University of Turku, Turku, Finland
name:Medical Biotechnology, VTT Technical Research Centre and University of Turku, Turku, Finland
name:Medical Biotechnology, VTT Technical Research Centre and University of Turku, Turku, Finland
name:Department of Signal Processing, Tampere University of Technology, Tampere, Finland
name:Medical Biotechnology, VTT Technical Research Centre and University of Turku, Turku, Finland
name:Department of Cancer Prevention, Institute for Cancer Research, Rikshospitalet-Radiumhospitalet Medical Centre, Oslo, Norway
name:Medical Biotechnology, VTT Technical Research Centre and University of Turku, Turku, Finland
name:Medical Biotechnology, VTT Technical Research Centre and University of Turku, Turku, Finland
name:Medical Biotechnology, VTT Technical Research Centre and University of Turku, Turku, Finland
name:Medical Biotechnology, VTT Technical Research Centre and University of Turku, Turku, Finland
name:Medical Biotechnology, VTT Technical Research Centre and University of Turku, Turku, Finland
name:Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland
name:Medical Biotechnology, VTT Technical Research Centre and University of Turku, Turku, Finland
name:Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland
name:Department of Signal Processing, Tampere University of Technology, Tampere, Finland
name:Medical Biotechnology, VTT Technical Research Centre and University of Turku, Turku, Finland
name:Computational Systems Biology Laboratory, Institute of Biomedicine and Genome-Scale Biology Research Program, University of Helsinki, Finland
name:Medical Biotechnology, VTT Technical Research Centre and University of Turku, Turku, Finland
name:Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland
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