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Title:
Analysis of alternative splicing with microarrays: successes and challenges | Genome Biology
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Recently, DNA microarrays have emerged as potentially powerful tools for analyzing alternative splicing. We briefly review the latest results in this field and highlight the current challenges that they have revealed.
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Keywords {π}
alternative, splicing, pubmed, article, splice, genes, data, google, scholar, analysis, gene, forms, cas, human, probes, microarray, exon, est, genome, microarrays, studies, array, lee, johnson, central, challenges, expression, alternativesplicing, reported, designed, show, transcript, results, largescale, individual, ests, evidence, events, exons, nat, res, biology, number, mrna, tissues, form, cell, types, problem, validation,
Topics {βοΈ}
large-scale transcriptional activity nonsense-mediated mrna decay consecutive exon-exon junction specific exon-exon junction alternative-splicing events involve large-scale microarray studies fiber-optic microarray platform previous large-scale mrna detect exon-skipping events putative alternative-splicing predictions 'exon-skip' form exon-skip form standard expression-data analysis predicting splice variant specific alternative-splicing event privacy choices/manage cookies individual exon-junction probes splice form profiling alternative splicing detect splice junctions exon-skipping events multiple splice forms 000 multi-exon genes intron information system large-scale studies [7β9] large-scale studies distinct splice forms alternative splice forms lending general support rna amplification protocols splice probe 3' splice-site usage cdna spotted array genuine alternative splicing fiber-optic arrays full-length isoforms exon creation/loss genome-wide survey article lee 'human transcriptome project' 1186/gb-2003-4-10-r66 model-based analysis microarray experiments tend alternative-splicing predictions expression index computation transcript fragments distant affymetrix microarray platform exon junction microarrays related subjects high-throughput manner
Questions {β}
- Are we ready for the complexities of 'one gene, many products' and for all the data required to track these many forms?
- [8] shed on the previous results from EST analysis?
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WebPage:
mainEntity:
headline:Analysis of alternative splicing with microarrays: successes and challenges
description:Recently, DNA microarrays have emerged as potentially powerful tools for analyzing alternative splicing. We briefly review the latest results in this field and highlight the current challenges that they have revealed.
datePublished:2004-06-21T00:00:00Z
dateModified:2004-06-21T00:00:00Z
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keywords:
Alternative Splice
Splice Form
Alternative Splice Form
Exon Probe
Splice Array
Animal Genetics and Genomics
Human Genetics
Plant Genetics and Genomics
Microbial Genetics and Genomics
Bioinformatics
Evolutionary Biology
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headline:Analysis of alternative splicing with microarrays: successes and challenges
description:Recently, DNA microarrays have emerged as potentially powerful tools for analyzing alternative splicing. We briefly review the latest results in this field and highlight the current challenges that they have revealed.
datePublished:2004-06-21T00:00:00Z
dateModified:2004-06-21T00:00:00Z
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Alternative Splice
Splice Form
Alternative Splice Form
Exon Probe
Splice Array
Animal Genetics and Genomics
Human Genetics
Plant Genetics and Genomics
Microbial Genetics and Genomics
Bioinformatics
Evolutionary Biology
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