We are analyzing https://link.springer.com/article/10.1186/cc5158.

Title:
Growth arrest-specific protein 6 plasma concentrations during septic shock | Critical Care
Description:
Introduction The product of growth arrest-specific gene 6 (Gas6) is a vitamin K dependent protein that is secreted by leucocytes and endothelial cells in response to injury and participates in cell survival, proliferation, migration and adhesion. Our purpose was to investigate plasma Gas6 concentration and its relation to organ dysfunction in patients with septic shock. Methods Forty-five patients with septic shock admitted to a medical adult intensive care unit were enrolled. Plasma Gas6 concentration was determined using enzyme-linked immunosorbent assay at days 1, 3, 7 and 14. Results The median (interquartile range) Gas6 concentration was 51 (5 to 95) pg/ml at admission. A positive correlation (Spearman rank-order coefficient [rs] = 0.37, P = 0.01) was found between Gas6 level and Sepsis-related Organ Failure Assessment score. Patients requiring renal support had higher Gas6 concentration that those without need for haemofiltration (76.5 [52 to 164] pg/ml versus 10.5 [1.5 to 80.5] pg/ml; P = 0.04). Moreover, there was a positive correlation between Gas6 and aspartate transaminase (rs = 0.42, P = 0.006) and between Gas6 and prothrombin time (rs = 0.45, P = 0.02). Although there was a progressive decline in Gas6 concentration in survivors (analysis of variance, P = 0.01), nonsurvivors exhibited persistently elevated Gas6. However, the two populations diverged only after day 7 (P = 0.04). Conclusion Plasma concentrations of Gas6 correlate with disease severity, especially with renal and hepatic dysfunction, in septic shock.
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Keywords {🔍}

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Topics {✒️}

sccm/esicm/accp/ats/sis growth arrest-specific gene necrotizing fasciitis inhibits tnf-alpha production article download pdf natural killer cells lipopolysaccharide-induced endotoxic shock alphavbeta5 integrin-mediated phagocytosis phosphatidylinositol 3-kinase-dependent pathway acute renal failure enzyme-linked immunosorbent assay gas6-axl-mediated survival investigate plasma concentrations anti-apoptotic effect c-reactive protein intensive care unit plasma strem-1 levels gas6 plasma concentrations suffered increased mortality including acute physiology mer tyrosine kinase gas6/axl system participates subsequent transcriptional activation authors’ original file delay cell death privacy choices/manage cookies plasma gas6 concentration gas6 plasma concentration infecting micro-organism recombinant human gas6 full access gas6 plasma level related subjects article number r8 organ transplant recipients increased glomerular expression renal support plasma concentrations higher gas6 concentration septic shock admitted article gibot maintaining cell function gas6/axl system gas6-axl mitogenic c-mer respiratory variables reliable severity markers logistic regression model recently attracted attention phosphate-buffered saline

Questions {❓}

Does Gas6 stimulate the release of these proteins?
How can these findings be reconciled?

Schema {🗺️}

WebPage:
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         headline:Growth arrest-specific protein 6 plasma concentrations during septic shock
         description:The product of growth arrest-specific gene 6 (Gas6) is a vitamin K dependent protein that is secreted by leucocytes and endothelial cells in response to injury and participates in cell survival, proliferation, migration and adhesion. Our purpose was to investigate plasma Gas6 concentration and its relation to organ dysfunction in patients with septic shock. Forty-five patients with septic shock admitted to a medical adult intensive care unit were enrolled. Plasma Gas6 concentration was determined using enzyme-linked immunosorbent assay at days 1, 3, 7 and 14. The median (interquartile range) Gas6 concentration was 51 (5 to 95) pg/ml at admission. A positive correlation (Spearman rank-order coefficient [rs] = 0.37, P = 0.01) was found between Gas6 level and Sepsis-related Organ Failure Assessment score. Patients requiring renal support had higher Gas6 concentration that those without need for haemofiltration (76.5 [52 to 164] pg/ml versus 10.5 [1.5 to 80.5] pg/ml; P = 0.04). Moreover, there was a positive correlation between Gas6 and aspartate transaminase (rs = 0.42, P = 0.006) and between Gas6 and prothrombin time (rs = 0.45, P = 0.02). Although there was a progressive decline in Gas6 concentration in survivors (analysis of variance, P = 0.01), nonsurvivors exhibited persistently elevated Gas6. However, the two populations diverged only after day 7 (P = 0.04). Plasma concentrations of Gas6 correlate with disease severity, especially with renal and hepatic dysfunction, in septic shock.
         datePublished:2007-01-22T00:00:00Z
         dateModified:2007-01-22T00:00:00Z
         pageStart:1
         pageEnd:5
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            Necrotizing Fasciitis
            Renal Support
            Activate Natural Killer Cell Receptor
            High Gas6 Concentration
            Intensive / Critical Care Medicine
            Emergency Medicine
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ScholarlyArticle:
      headline:Growth arrest-specific protein 6 plasma concentrations during septic shock
      description:The product of growth arrest-specific gene 6 (Gas6) is a vitamin K dependent protein that is secreted by leucocytes and endothelial cells in response to injury and participates in cell survival, proliferation, migration and adhesion. Our purpose was to investigate plasma Gas6 concentration and its relation to organ dysfunction in patients with septic shock. Forty-five patients with septic shock admitted to a medical adult intensive care unit were enrolled. Plasma Gas6 concentration was determined using enzyme-linked immunosorbent assay at days 1, 3, 7 and 14. The median (interquartile range) Gas6 concentration was 51 (5 to 95) pg/ml at admission. A positive correlation (Spearman rank-order coefficient [rs] = 0.37, P = 0.01) was found between Gas6 level and Sepsis-related Organ Failure Assessment score. Patients requiring renal support had higher Gas6 concentration that those without need for haemofiltration (76.5 [52 to 164] pg/ml versus 10.5 [1.5 to 80.5] pg/ml; P = 0.04). Moreover, there was a positive correlation between Gas6 and aspartate transaminase (rs = 0.42, P = 0.006) and between Gas6 and prothrombin time (rs = 0.45, P = 0.02). Although there was a progressive decline in Gas6 concentration in survivors (analysis of variance, P = 0.01), nonsurvivors exhibited persistently elevated Gas6. However, the two populations diverged only after day 7 (P = 0.04). Plasma concentrations of Gas6 correlate with disease severity, especially with renal and hepatic dysfunction, in septic shock.
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      dateModified:2007-01-22T00:00:00Z
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         Necrotizing Fasciitis
         Renal Support
         Activate Natural Killer Cell Receptor
         High Gas6 Concentration
         Intensive / Critical Care Medicine
         Emergency Medicine
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               name:Service de Réanimation Médicale, Avenue du Maréchal de Lattre de Tassigny, Hôpital Central, Nancy, France
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      name:Coordination Circulation, Projet Avenir INSERM, France
      name:Laboratoire d'Immunologie, Nancy, France
      name:Service de Réanimation Médicale, Avenue du Maréchal de Lattre de Tassigny, Hôpital Central, Nancy, France
      name:Service de Réanimation Médicale, Avenue du Maréchal de Lattre de Tassigny, Hôpital Central, Nancy, France
      name:Service de Réanimation Médicale, Avenue du Maréchal de Lattre de Tassigny, Hôpital Central, Nancy, France
      name:Service de Réanimation Médicale, Avenue du Maréchal de Lattre de Tassigny, Hôpital Central, Nancy, France
      name:Service de Réanimation Médicale, Avenue du Maréchal de Lattre de Tassigny, Hôpital Central, Nancy, France

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