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Title:
Reactive oxygen species: toxic molecules or spark of life? | Critical Care
Description:
Increases in reactive oxygen species (ROS) and tissue evidence of oxidative injury are common in patients with inflammatory processes or tissue injury. This has led to many clinical attempts to scavenge ROS and reduce oxidative injury. However, we live in an oxygen rich environment and ROS and their chemical reactions are part of the basic chemical processes of normal metabolism. Accordingly, organisms have evolved sophisticated mechanisms to control these reactive molecules. Recently, it has become increasingly evident that ROS also play a role in the regulation of many intracellular signaling pathways that are important for normal cell growth and inflammatory responses that are essential for host defense. Thus, simply trying to scavenge ROS is likely not possible and potentially harmful. The
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Keywords {🔍}

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Topics {✒️}

chronic granulomatous disease tnf-alpha-induced oxidant generation sarco/endoplasmic reticulum calcium reactive nitrogen species polyethylene glycol-superoxide dismutase n-acetylcysteine decreases measures n-acetylcysteine enhances recovery multi-organ system failure n-acetylcysteine versus placebo apoptosis signal-regulating kinase anti-oxidant mechanisms cu/zn isoform present arginine-depleted cells leading human manganese-superoxide dismutase superoxide-generating oxidase mox1 small g-protein rac nadh/nadph oxidase-derived irreversible protein cross-linking reactive oxygen species 'reactive oxygen species' glutathione disulfide/glutathione couple de gaudio ar authors’ original file peroxynitrite-mediated cellular injury acute lung injury lung lipid peroxidation signal transduction pathways privacy choices/manage cookies mccord jm lipid peroxides including lipid peroxidation related subjects article magder random destructive species smooth muscle growth p22phox-based nadh oxidase nitric oxide synthases killing invading microorganisms vascular smooth muscle intracellular signal transduction n-acetylcysteine reduces hepatic blood flow critical care tumour necrosis factor oxygen radical scavenger neutrophil chemotactic factor mixed disulfide prevents synthetic superoxide dismutase tumor suppressor pten central role

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Reactive oxygen species: toxic molecules or spark of life?
Reactive oxygen species: toxic molecules or spark of life?

Schema {🗺️}

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         headline:Reactive oxygen species: toxic molecules or spark of life?
         description:Increases in reactive oxygen species (ROS) and tissue evidence of oxidative injury are common in patients with inflammatory processes or tissue injury. This has led to many clinical attempts to scavenge ROS and reduce oxidative injury. However, we live in an oxygen rich environment and ROS and their chemical reactions are part of the basic chemical processes of normal metabolism. Accordingly, organisms have evolved sophisticated mechanisms to control these reactive molecules. Recently, it has become increasingly evident that ROS also play a role in the regulation of many intracellular signaling pathways that are important for normal cell growth and inflammatory responses that are essential for host defense. Thus, simply trying to scavenge ROS is likely not possible and potentially harmful. The 'normal' level of ROS will also likely vary in different tissues and even in different parts of cells. In this paper, the terminology and basic chemistry of reactive species are reviewed. Examples and mechanisms of tissue injury by ROS as well as their positive role as signaling molecules are discussed. Hopefully, a better understanding of the nature of ROS will lead to better planned therapeutic attempts to manipulate the concentrations of these important molecules. We need to regulate ROS, not eradicate them.
         datePublished:2006-02-03T00:00:00Z
         dateModified:2006-02-03T00:00:00Z
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            Nitric Oxide
            Chronic Granulomatous Disease
            Oxidative Injury
            Reactive Nitrogen Species
            Intensive / Critical Care Medicine
            Emergency Medicine
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      headline:Reactive oxygen species: toxic molecules or spark of life?
      description:Increases in reactive oxygen species (ROS) and tissue evidence of oxidative injury are common in patients with inflammatory processes or tissue injury. This has led to many clinical attempts to scavenge ROS and reduce oxidative injury. However, we live in an oxygen rich environment and ROS and their chemical reactions are part of the basic chemical processes of normal metabolism. Accordingly, organisms have evolved sophisticated mechanisms to control these reactive molecules. Recently, it has become increasingly evident that ROS also play a role in the regulation of many intracellular signaling pathways that are important for normal cell growth and inflammatory responses that are essential for host defense. Thus, simply trying to scavenge ROS is likely not possible and potentially harmful. The 'normal' level of ROS will also likely vary in different tissues and even in different parts of cells. In this paper, the terminology and basic chemistry of reactive species are reviewed. Examples and mechanisms of tissue injury by ROS as well as their positive role as signaling molecules are discussed. Hopefully, a better understanding of the nature of ROS will lead to better planned therapeutic attempts to manipulate the concentrations of these important molecules. We need to regulate ROS, not eradicate them.
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