We are analyzing https://link.springer.com/article/10.1186/cc2872.

Title:
Acute renal failure – definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group | Critical Care
Description:
Introduction There is no consensus definition of acute renal failure (ARF) in critically ill patients. More than 30 different definitions have been used in the literature, creating much confusion and making comparisons difficult. Similarly, strong debate exists on the validity and clinical relevance of animal models of ARF; on choices of fluid management and of end-points for trials of new interventions in this field; and on how information technology can be used to assist this process. Accordingly, we sought to review the available evidence, make recommendations and delineate key questions for future studies. Methods We undertook a systematic review of the literature using Medline and PubMed searches. We determined a list of key questions and convened a 2-day consensus conference to develop summary statements via a series of alternating breakout and plenary sessions. In these sessions, we identified supporting evidence and generated recommendations and/or directions for future research. Results We found sufficient consensus on 47 questions to allow the development of recommendations. Importantly, we were able to develop a consensus definition for ARF. In some cases it was also possible to issue useful consensus recommendations for future investigations. We present a summary of the findings. (Full versions of the six workgroups
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Keywords {🔍}

arf, renal, article, acute, google, scholar, pubmed, failure, care, clinical, patients, cas, consensus, creatinine, kidney, models, therapy, information, outcome, patient, fluid, med, function, animal, dialysis, studies, disease, technology, endpoints, classification, definition, critically, adqi, ill, recommendations, criteria, table, data, research, questions, study, serum, baseline, conference, full, workgroup, trials, evidence, system, intensive,

Topics {✒️}

randomized controlled trial glomerular filtration rate continuous veno-venous haemofiltration renal replacement therapy 'end-stage renal disease' end-stage kidney disease endotoxin-induced renal failure le gall jr 'early goal-directed' therapy early goal-directed therapy full size image acute renal failure article download pdf randomized clinical trial altering clinical end-points acute circulatory failure acute lung injury prospective randomized study acute dialysis therapy central venous pressure acute renal dysfunction renal support technology volume replacement chronic renal disease blood urea nitrogen pulmonary-artery catheters acute dialysis care authors’ original file surrogate end-points research studies testing chronic kidney disease serum urea nitrogen renal blood flow related subjects privacy choices/manage cookies organ dysfunction/failure full access ensure full participation leading animal models animal models investigating primary renal diseases english language articles acute dialysis setting renal failure stable survival rate adqi group reviewed article number r204 steady-state condition tubular hypoxic damage pinsky mr

Questions {❓}

Capuzzo M, Valpondi V, Zardi S, Belin M, De Luca S, Alvisi R: Mortality of intensive care patients: at a fixed point in time or in the hospital?

Schema {🗺️}

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         description:There is no consensus definition of acute renal failure (ARF) in critically ill patients. More than 30 different definitions have been used in the literature, creating much confusion and making comparisons difficult. Similarly, strong debate exists on the validity and clinical relevance of animal models of ARF; on choices of fluid management and of end-points for trials of new interventions in this field; and on how information technology can be used to assist this process. Accordingly, we sought to review the available evidence, make recommendations and delineate key questions for future studies. We undertook a systematic review of the literature using Medline and PubMed searches. We determined a list of key questions and convened a 2-day consensus conference to develop summary statements via a series of alternating breakout and plenary sessions. In these sessions, we identified supporting evidence and generated recommendations and/or directions for future research. We found sufficient consensus on 47 questions to allow the development of recommendations. Importantly, we were able to develop a consensus definition for ARF. In some cases it was also possible to issue useful consensus recommendations for future investigations. We present a summary of the findings. (Full versions of the six workgroups' findings are available on the internet at http://www.ADQI.net ) Despite limited data, broad areas of consensus exist for the physiological and clinical principles needed to guide the development of consensus recommendations for defining ARF, selection of animal models, methods of monitoring fluid therapy, choice of physiological and clinical end-points for trials, and the possible role of information technology.
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      headline:Acute renal failure – definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group
      description:There is no consensus definition of acute renal failure (ARF) in critically ill patients. More than 30 different definitions have been used in the literature, creating much confusion and making comparisons difficult. Similarly, strong debate exists on the validity and clinical relevance of animal models of ARF; on choices of fluid management and of end-points for trials of new interventions in this field; and on how information technology can be used to assist this process. Accordingly, we sought to review the available evidence, make recommendations and delineate key questions for future studies. We undertook a systematic review of the literature using Medline and PubMed searches. We determined a list of key questions and convened a 2-day consensus conference to develop summary statements via a series of alternating breakout and plenary sessions. In these sessions, we identified supporting evidence and generated recommendations and/or directions for future research. We found sufficient consensus on 47 questions to allow the development of recommendations. Importantly, we were able to develop a consensus definition for ARF. In some cases it was also possible to issue useful consensus recommendations for future investigations. We present a summary of the findings. (Full versions of the six workgroups' findings are available on the internet at http://www.ADQI.net ) Despite limited data, broad areas of consensus exist for the physiological and clinical principles needed to guide the development of consensus recommendations for defining ARF, selection of animal models, methods of monitoring fluid therapy, choice of physiological and clinical end-points for trials, and the possible role of information technology.
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         Emergency Medicine
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      name:Department of Medicine, University of California, San Diego, USA
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