We are analyzing https://link.springer.com/article/10.1186/bcr52.

Title:
Tyrosine kinase signalling in breast cancer: Epidermal growth factor receptor - convergence point for signal integration and diversification | Breast Cancer Research
Description:
Cross-communication between different signalling systems is critical for the integration of multiple and changing environmental influences on individual cells. The epidermal growth factor receptor (EGFR) has been identified as a key element in the complex signalling network that is utilized by various classes of cell-surface receptors. This nonclassical mode of signalling system cross-talk, in distinction to receptor activation induced by cognate ligands, has been termed
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Keywords {🔍}

receptor, egfr, pubmed, article, growth, google, scholar, cas, kinase, factor, tyrosine, activation, epidermal, transactivation, signalling, phosphorylation, protein, biol, cells, receptors, chem, jbc, signal, signaling, cell, cancer, egf, src, critical, stimulation, activity, gpcrs, breast, ullrich, gproteincoupled, kinases, pathway, nature, crosstalk, mapk, gpcrinduced, central, family, role, cellular, pathways, mitogenactivated, zwick, downstream, calcium,

Topics {✒️}

ras-mitogen-activated protein kinase g-protein-mediated growth control g-protein-coupled receptor genes g-protein-coupled p2y2 receptor mitogen-activated protein kinase g-protein-coupled receptor agonists g-protein-mediated signal generation g-protein-transactivated egf receptor pi-3k-stimulated phospholipid turnover g-protein-coupled receptors ca2+/calmodulin dependent transactivation mitogenic g-protein signalling couples g-protein signalling platelet-derived growth factor intracellular rtk-rtk cross-talk transforming growth factor-α key elements pro-hb-egf important membrane-spanning protein inter-receptor cross-talk michael leserer & axel ullrich c-src-mediated phosphorylation signalling system cross-talk c-src tyrosine kinase combinatorial ligand-receptor interactions cell-type specific phosphorylation adhesion-dependent cell survival della rocca gj kinase-inactive pyk2 mutant gpcr-induced tyrosine phosphorylation β-arrestin-dependent formation protein-coupled receptor membrane-anchored growth factors protein-coupled receptors noradrenaline-induced mapk activation gpcr-induced egfr transactivation lpa-induced mapk activation cell-density dependent manner gpcr-induced mapk activation gpcr-induced egfr activation dominant-negative egfr mutant breast cancer research c-fos gene transcription growth factor signaling distinct calcium-dependent pathways g-protein signaling angiotensin ii stimulation gq-mediated mapk activation c-jun transcription growth factor precursor g-protein activation [25

Schema {🗺️}

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         headline:Tyrosine kinase signalling in breast cancer: Epidermal growth factor receptor - convergence point for signal integration and diversification
         description:Cross-communication between different signalling systems is critical for the integration of multiple and changing environmental influences on individual cells. The epidermal growth factor receptor (EGFR) has been identified as a key element in the complex signalling network that is utilized by various classes of cell-surface receptors. This nonclassical mode of signalling system cross-talk, in distinction to receptor activation induced by cognate ligands, has been termed 'signal transactivation'. With the EGFR as the convergence point and distribution focus, this scenario may involve signals emitted by other members of the tyrosine kinase family, cytokine receptors, ion channels, G-protein-coupled receptors and integrins.
         datePublished:2000-06-01T00:00:00Z
         dateModified:2000-06-01T00:00:00Z
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            Cancer Research
            Oncology
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      headline:Tyrosine kinase signalling in breast cancer: Epidermal growth factor receptor - convergence point for signal integration and diversification
      description:Cross-communication between different signalling systems is critical for the integration of multiple and changing environmental influences on individual cells. The epidermal growth factor receptor (EGFR) has been identified as a key element in the complex signalling network that is utilized by various classes of cell-surface receptors. This nonclassical mode of signalling system cross-talk, in distinction to receptor activation induced by cognate ligands, has been termed 'signal transactivation'. With the EGFR as the convergence point and distribution focus, this scenario may involve signals emitted by other members of the tyrosine kinase family, cytokine receptors, ion channels, G-protein-coupled receptors and integrins.
      datePublished:2000-06-01T00:00:00Z
      dateModified:2000-06-01T00:00:00Z
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         epidermal growth factor receptor
         G-protein-coupled receptors
         integrins
         metalloproteinases
         Ras-mitogen-activated protein kinase
         transactivation
         Cancer Research
         Oncology
         Surgical Oncology
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