We are analyzing https://link.springer.com/article/10.1186/bcr50.

Title:
Tyrosine kinase signalling in breast cancer: Insulin-like growth factors and their receptors in breast cancer | Breast Cancer Research
Description:
The insulin-like growth factor (IGF) system exerts pleiotropic effects on mammalian cells. This review focuses on type I IGF receptor (IGF1R)-mediated signal transduction and its relevance in breast cancer. Upon activation by the IGFs, IGF1R, a transmembrane tyrosine kinase receptor, undergoes autophosphorylation, and then binds and phosphorylates additional signaling molecules. These intermediates initiate a series of downstream signaling events that are involved in multiple physiologic processes for cells. Recent data demonstrate that the IGF receptor system actively interacts with the estrogen receptor and integrin receptor systems. Cross-talk among these pathways regulates breast cancer proliferation, protection from cell death, and metastasis. Better understanding of IGF biochemical signaling pathways is of utmost importance for developing therapies for breast cancer.
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Keywords {🔍}

cancer, breast, pubmed, google, scholar, growth, cas, receptor, article, insulinlike, cells, factor, igf, insulin, igfr, signaling, kinase, human, activation, irs, igfii, res, tyrosine, cell, expression, receptors, pathways, proteins, substrate, igfi, biol, estrogen, binding, protein, chem, igfs, factori, jbc, central, activity, signalling, integrin, malignant, gene, endocrinol, factors, yee, system, role, phosphorylation,

Topics {✒️}

cation-independent mannose-6-phosphate receptor ras-mitogen-activated protein kinase src-homology 2/collagen-α proteins chemotherapy-induced cell death growth-factor-i-receptor igf-i-mimetic antibody carboxyl-terminal src kinase growth factor-binding protein named igfbp-related proteins alpha-v-beta3 integrin tyrosine kinase signalling growth factor-ii receptor hormone-binding domain recruits grb-2-sos complexes decreased disease-free survival ceramide signalling pathways article zhang adhesion-dependent signaling system hormone-receptor complex related subjects ligand-activated transcription factor inhibiting ligand-independent activation douglas yee high-affinity binding proteins igf-ii binding domain mediated signal transduction characterized igf1r-signaling molecule myers mg jones ji inhibited igf-mediated activation mitogenic signal transduction high igf-ii expression dominant negative mutant privacy choices/manage cookies insulin receptor-igf1r hybrids human breast cancer messenger ribonucleic acid beitner-johnson tumor suppressor gene natl cancer inst multifunctional binding protein breast cancer treatment protein grb2 interacts increased igf-ii expression single-chain molecules ras signalling human breast diseases smooth muscle cells growth factor-ii programmed cell death

Schema {🗺️}

WebPage:
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         headline:Tyrosine kinase signalling in breast cancer: Insulin-like growth factors and their receptors in breast cancer
         description:The insulin-like growth factor (IGF) system exerts pleiotropic effects on mammalian cells. This review focuses on type I IGF receptor (IGF1R)-mediated signal transduction and its relevance in breast cancer. Upon activation by the IGFs, IGF1R, a transmembrane tyrosine kinase receptor, undergoes autophosphorylation, and then binds and phosphorylates additional signaling molecules. These intermediates initiate a series of downstream signaling events that are involved in multiple physiologic processes for cells. Recent data demonstrate that the IGF receptor system actively interacts with the estrogen receptor and integrin receptor systems. Cross-talk among these pathways regulates breast cancer proliferation, protection from cell death, and metastasis. Better understanding of IGF biochemical signaling pathways is of utmost importance for developing therapies for breast cancer.
         datePublished:2000-06-01T00:00:00Z
         dateModified:2000-06-01T00:00:00Z
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            insulin-like growth factor
            insulin-like growth factor receptor
            signal transduction
            Cancer Research
            Oncology
            Surgical Oncology
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      headline:Tyrosine kinase signalling in breast cancer: Insulin-like growth factors and their receptors in breast cancer
      description:The insulin-like growth factor (IGF) system exerts pleiotropic effects on mammalian cells. This review focuses on type I IGF receptor (IGF1R)-mediated signal transduction and its relevance in breast cancer. Upon activation by the IGFs, IGF1R, a transmembrane tyrosine kinase receptor, undergoes autophosphorylation, and then binds and phosphorylates additional signaling molecules. These intermediates initiate a series of downstream signaling events that are involved in multiple physiologic processes for cells. Recent data demonstrate that the IGF receptor system actively interacts with the estrogen receptor and integrin receptor systems. Cross-talk among these pathways regulates breast cancer proliferation, protection from cell death, and metastasis. Better understanding of IGF biochemical signaling pathways is of utmost importance for developing therapies for breast cancer.
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      dateModified:2000-06-01T00:00:00Z
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         insulin-like growth factor
         insulin-like growth factor receptor
         signal transduction
         Cancer Research
         Oncology
         Surgical Oncology
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                  type:Organization
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      name:University of Minnesota Cancer Center
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Person:
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               type:PostalAddress
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PostalAddress:
      name:University of Minnesota Cancer Center, Minneapolis, USA
      name:University of Minnesota Cancer Center, Minneapolis, USA

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