We are analyzing https://link.springer.com/article/10.1186/bcr452.

Title:
Progesterone receptors - animal models and cell signaling in breast cancer: The role of oestrogen and progesterone receptors in human mammary development and tumorigenesis | Breast Cancer Research
Description:
A relatively small number of cells in the normal human mammary gland express receptors for oestrogen and progesterone (ER and PR), and there is almost complete dissociation between steroid receptor expression and proliferation. Increased expression of the ER alpha (ERα) and loss of the inverse relationship between receptor expression and proliferation occur at the very earliest stages of tumorigenesis, implying that dysregulation of ERα expression contributes to breast tumour formation. There is evidence also for alterations in the ratio between the two PR isoforms in premalignant breast lesions. Elucidation of the factors mediating the effects of oestradiol and progesterone on development of the normal breast and of the mechanisms by which expression of the ERα and the PR isoforms is controlled could identify new targets for breast cancer prevention and improved prediction of breast cancer risk.
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Keywords {🔍}

breast, receptor, expression, cancer, human, progesterone, erα, article, mammary, google, scholar, pubmed, cells, cas, normal, receptors, development, gland, proliferation, oestradiol, estrogen, studies, erβ, tumorigenesis, tumours, role, epithelium, ductal, oestrogen, steroid, pra, prb, therapy, data, risk, nuclear, tissue, early, luminal, invasive, cell, lesions, epithelial, mice, function, anderson, increased, effects, hormone, activity,

Topics {✒️}

dual-label immunofluorescent techniques estrogen receptor β-isoform nearby division-competent cells nuclear receptor superfamily estrogen-progestin replacement therapy fewer erα-positive cells prevailing oestradiol/progesterone concentrations steroid receptor-expressing cells hormone replacement therapy proliferating erα-positive cells human estrogen receptor oestrogen receptor β present article reviews privacy choices/manage cookies estrogen receptor knock estrogen versus estrogen intermediate nuclear grade related subjects estrogen receptor alpha human progesterone receptor estrogen receptor expression breast cancer risk postmenopausal breast cancer high nuclear grade normal human breast good prognostic factor invasive breast carcinomas invasive breast cancer positive growth factors human mammary gland mammary gland indirectly human mammary epithelium normal mammary gland normal breast epithelium normal mammary epithelium human breast tissue natl cancer inst human breast tumours article anderson cancer clin oncol oestrogen replacement therapy oestrogen receptor expression steroid receptor expression breast cancer prevention breast cancer compared juxtacrine growth factors human breast development human mammary development breast tumours arise progesterone receptor expression

Questions {❓}

Couse JF, Korach K: Estrogen receptor null mice: what have we learned and where will they lead us?
Speirs V: Oestrogen receptor β in breast cancer: good, bad or still too early to tell?

Schema {🗺️}

WebPage:
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         headline:Progesterone receptors - animal models and cell signaling in breast cancer: The role of oestrogen and progesterone receptors in human mammary development and tumorigenesis
         description:A relatively small number of cells in the normal human mammary gland express receptors for oestrogen and progesterone (ER and PR), and there is almost complete dissociation between steroid receptor expression and proliferation. Increased expression of the ER alpha (ERα) and loss of the inverse relationship between receptor expression and proliferation occur at the very earliest stages of tumorigenesis, implying that dysregulation of ERα expression contributes to breast tumour formation. There is evidence also for alterations in the ratio between the two PR isoforms in premalignant breast lesions. Elucidation of the factors mediating the effects of oestradiol and progesterone on development of the normal breast and of the mechanisms by which expression of the ERα and the PR isoforms is controlled could identify new targets for breast cancer prevention and improved prediction of breast cancer risk.
         datePublished:2002-10-01T00:00:00Z
         dateModified:2002-10-01T00:00:00Z
         pageStart:1
         pageEnd:5
         sameAs:https://doi.org/10.1186/bcr452
         keywords:
            breast tumours
            normal mammary epithelium
            oestrogen receptor
            progesterone receptor
            Cancer Research
            Oncology
            Surgical Oncology
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            issn:
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         author:
               name:Elizabeth Anderson
               affiliation:
                     name:Tumour Biochemistry Laboratory, Christie Hospital NHS Trust
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                        name:Tumour Biochemistry Laboratory, Christie Hospital NHS Trust, Manchester, UK
                        type:PostalAddress
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ScholarlyArticle:
      headline:Progesterone receptors - animal models and cell signaling in breast cancer: The role of oestrogen and progesterone receptors in human mammary development and tumorigenesis
      description:A relatively small number of cells in the normal human mammary gland express receptors for oestrogen and progesterone (ER and PR), and there is almost complete dissociation between steroid receptor expression and proliferation. Increased expression of the ER alpha (ERα) and loss of the inverse relationship between receptor expression and proliferation occur at the very earliest stages of tumorigenesis, implying that dysregulation of ERα expression contributes to breast tumour formation. There is evidence also for alterations in the ratio between the two PR isoforms in premalignant breast lesions. Elucidation of the factors mediating the effects of oestradiol and progesterone on development of the normal breast and of the mechanisms by which expression of the ERα and the PR isoforms is controlled could identify new targets for breast cancer prevention and improved prediction of breast cancer risk.
      datePublished:2002-10-01T00:00:00Z
      dateModified:2002-10-01T00:00:00Z
      pageStart:1
      pageEnd:5
      sameAs:https://doi.org/10.1186/bcr452
      keywords:
         breast tumours
         normal mammary epithelium
         oestrogen receptor
         progesterone receptor
         Cancer Research
         Oncology
         Surgical Oncology
      image:
      isPartOf:
         name:Breast Cancer Research
         issn:
            1465-542X
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                     name:Tumour Biochemistry Laboratory, Christie Hospital NHS Trust, Manchester, UK
                     type:PostalAddress
                  type:Organization
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      name:BioMed Central
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         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
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Person:
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      affiliation:
            name:Tumour Biochemistry Laboratory, Christie Hospital NHS Trust
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               name:Tumour Biochemistry Laboratory, Christie Hospital NHS Trust, Manchester, UK
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PostalAddress:
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