We are analyzing https://link.springer.com/article/10.1186/bcr416.

Title:
E-cadherin and loss of heterozygosity at chromosome 16 in breast carcinogenesis: different genetic pathways in ductal and lobular breast cancer? | Breast Cancer Research
Description:
Loss of heterozygosity at the long arm of chromosome 16 is one of the most frequent genetic events in breast cancer. In the search for tumour suppressor genes that are the target of loss of heterozygosity at 16q, the E-cadherin gene CDH1 was unveiled by the identification of truncating mutations in the retained copy. However, only lobular tumours showed E-cadherin mutations. Whereas investigations are still devoted to finding the target genes in the more frequent ductal breast cancers, other studies suspect the E-cadherin gene to also be the target in this tumour type. The present article discusses the plausibility of those two lines of thought.
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Keywords {🔍}

ecadherin, breast, cancer, pubmed, lobular, loh, google, scholar, article, carcinoma, cas, ductal, tumour, loss, gene, cdh, van, situ, genetic, mutations, tumours, expression, heterozygosity, cletonjansen, gastric, genes, dcis, lcis, chromosome, suppressor, central, data, target, carcinomas, protein, inactivation, cornelisse, frequent, mutation, cells, model, invasive, role, vos, human, roy, function, cellular, event, progression,

Topics {✒️}

suppresses beta-catenin–lef/tcf-dependent transcription anne-marie cleton-jansen e-cadherin invasion-suppressor gene high-throughput screening methods de leeuw wj e-cadherin mutation status detectable e-cadherin mutation germline e-cadherin gene regulate e-cadherin transcription article cleton-jansen e-cadherin gene expression e-cadherin protein expression e-cadherin germline mutations somatic e-cadherin mutations e-cadherin gene cdh1 absent e-cadherin protein e-cadherin plasma membrane decreased e-cadherin expression de leeuw wjf dr cbj vos e-cadherin staining tumour suppressor gene present article discusses privacy choices/manage cookies e-cadherin gene cleton-jansen a mutation detection method de herreros ag e-cadherin expression human e-cadherin tumour suppressor genes references vleminckx e-cadherin molecules anchor e-cadherin e-cadherin activity detect e-cadherin breast cancer progression e-cad-herin central role breast tumors stratified diffuse gastric cancer invasion suppressor function epithelial tumour cells lobular tumour cells invasion suppressor role e-cadherin inactivation european economic area integrin-linked kinase [6] comparative genomic hybridisation rate-limiting factor

Questions {❓}

Beavon IR: Regulation of E-cadherin: does hypoxia initiate the metastatic cascade?
E-cadherin and loss of heterozygosity at chromosome 16 in breast carcinogenesis: different genetic pathways in ductal and lobular breast cancer?
E-cadherin and loss of heterozygosity at chromosome 16 in breast carcinogenesis: different genetic pathways in ductal and lobular breast cancer?

Schema {🗺️}

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         headline:E-cadherin and loss of heterozygosity at chromosome 16 in breast carcinogenesis: different genetic pathways in ductal and lobular breast cancer?
         description:Loss of heterozygosity at the long arm of chromosome 16 is one of the most frequent genetic events in breast cancer. In the search for tumour suppressor genes that are the target of loss of heterozygosity at 16q, the E-cadherin gene CDH1 was unveiled by the identification of truncating mutations in the retained copy. However, only lobular tumours showed E-cadherin mutations. Whereas investigations are still devoted to finding the target genes in the more frequent ductal breast cancers, other studies suspect the E-cadherin gene to also be the target in this tumour type. The present article discusses the plausibility of those two lines of thought.
         datePublished:2001-12-31T00:00:00Z
         dateModified:2001-12-31T00:00:00Z
         pageStart:1
         pageEnd:4
         sameAs:https://doi.org/10.1186/bcr416
         keywords:
            hereditary cancer
            loss of heterozygosity
            mutation
            tumour progression
            tumour suppressor genes
            Cancer Research
            Oncology
            Surgical Oncology
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      headline:E-cadherin and loss of heterozygosity at chromosome 16 in breast carcinogenesis: different genetic pathways in ductal and lobular breast cancer?
      description:Loss of heterozygosity at the long arm of chromosome 16 is one of the most frequent genetic events in breast cancer. In the search for tumour suppressor genes that are the target of loss of heterozygosity at 16q, the E-cadherin gene CDH1 was unveiled by the identification of truncating mutations in the retained copy. However, only lobular tumours showed E-cadherin mutations. Whereas investigations are still devoted to finding the target genes in the more frequent ductal breast cancers, other studies suspect the E-cadherin gene to also be the target in this tumour type. The present article discusses the plausibility of those two lines of thought.
      datePublished:2001-12-31T00:00:00Z
      dateModified:2001-12-31T00:00:00Z
      pageStart:1
      pageEnd:4
      sameAs:https://doi.org/10.1186/bcr416
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         hereditary cancer
         loss of heterozygosity
         mutation
         tumour progression
         tumour suppressor genes
         Cancer Research
         Oncology
         Surgical Oncology
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Person:
      name:Anne-Marie Cleton-Jansen
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            address:
               name:Departments of Pathology and Human and Clinical Genetics, Leiden University Medical Centre, Leiden, The Netherlands
               type:PostalAddress
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      email:[email protected]
PostalAddress:
      name:Departments of Pathology and Human and Clinical Genetics, Leiden University Medical Centre, Leiden, The Netherlands

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