We are analyzing https://link.springer.com/article/10.1186/bcr3401.

Title:
The Hedgehog signalling pathway in breast development, carcinogenesis and cancer therapy | Breast Cancer Research
Description:
Despite the progress achieved in breast cancer screening and therapeutic innovations, the basal-like subtype of breast cancer (BLBC) still represents a particular clinical challenge. In order to make an impact on survival in this type of aggressive breast cancer, new targeted therapeutic agents are urgently needed. Aberrant activation of the Hedgehog (Hh) signalling pathway has been unambiguously tied to cancer development and progression in a variety of solid malignancies, and the recent approval of vismodegib, an orally bioavailable small-molecule inhibitor of Smoothened, validates Hh signalling as a valuable therapeutic target. A number of recent publications have highlighted a role for Hh signalling in breast cancer models and clinical specimens. Interestingly, Hh ligand overexpression is associated with the BLBC phenotype and a poor outcome in terms of metastasis and breast cancer-related death. In this review, we provide a comprehensive overview of the canonical Hh signalling pathway in mammals, highlight its roles in mammary gland development and breast carcinogenesis and discuss its potential therapeutic value in BLBC.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Science
Health & Fitness

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We're unsure how the site profits.

Earning money isn't the goal of every website; some are designed to offer support or promote social causes. People have different reasons for creating websites. This might be one such reason. Link.springer.com could be getting rich in stealth mode, or the way it's monetizing isn't detectable.

Keywords {🔍}

pubmed, cancer, breast, article, google, scholar, cas, hedgehog, signalling, cells, pathway, mammary, gli, development, cell, ptch, central, expression, smo, signaling, ligand, gland, activation, tumour, nature, epithelial, mouse, paracrine, stem, shh, blbc, growth, cancers, human, figure, res, target, metastasis, primary, clinical, protein, stromal, therapeutic, role, transcription, metastatic, identified, proteins, evidence, biol,

Topics {✒️}

parathyroid hormone-related protein transforming growth factor-β transcription factor nf-κb surrounding wild-type cells enhanced mammosphere-forming efficiency hh-ptch1-smo-gli paradigm patched/hedgehog/smoothened signalling pathway rna interference-mediated knockdown gov/ct2/home] dlugosz 7-pass transmembrane-spanning protein triple-negative model attenuated breast cancer-related death growth arrest-specific gene g-protein-coupled receptors [13] tamoxifen-resistant breast tumours experience loco-regional recurrence hedgehog-gli signaling drives alternative growth-promoting mechanism neutralising anti-hh antibody reduced lobular-alveolar development division-competent cell types blocking hedgehog/gli pathway bulb-shaped structures made tissue/cell-specific pattern multiple hh-responsive tissues progesterone receptor-negative status advanced basal-cell carcinoma long-lived unipotent basal genome-wide transcript analysis acquired tumour-specific mutation human melanoma-initiating cells autocrine/juxtacrine loop post-pubertal ductal elongation ras-mek/akt pathways full size image ligand-independent signalling observed hh ligand-dependent activation dose-limiting side effects ligand-dependent breast carcinogenesis exclude autocrine signalling active hh signalling autocrine/juxtacrine manner intact primary cilium reis-filho js o'brien sj o'toole small-molecule hedgehog larger tumour size small molecule robotnikinin promotes osteoclast maturation

Questions {❓}

Bissell MJ, Hines WC: Why don't we get more cancer?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:The Hedgehog signalling pathway in breast development, carcinogenesis and cancer therapy
         description:Despite the progress achieved in breast cancer screening and therapeutic innovations, the basal-like subtype of breast cancer (BLBC) still represents a particular clinical challenge. In order to make an impact on survival in this type of aggressive breast cancer, new targeted therapeutic agents are urgently needed. Aberrant activation of the Hedgehog (Hh) signalling pathway has been unambiguously tied to cancer development and progression in a variety of solid malignancies, and the recent approval of vismodegib, an orally bioavailable small-molecule inhibitor of Smoothened, validates Hh signalling as a valuable therapeutic target. A number of recent publications have highlighted a role for Hh signalling in breast cancer models and clinical specimens. Interestingly, Hh ligand overexpression is associated with the BLBC phenotype and a poor outcome in terms of metastasis and breast cancer-related death. In this review, we provide a comprehensive overview of the canonical Hh signalling pathway in mammals, highlight its roles in mammary gland development and breast carcinogenesis and discuss its potential therapeutic value in BLBC.
         datePublished:2013-03-28T00:00:00Z
         dateModified:2013-03-28T00:00:00Z
         pageStart:1
         pageEnd:14
         sameAs:https://doi.org/10.1186/bcr3401
         keywords:
            Breast Cancer
            Basal Cell Carcinoma
            Primary Cilium
            Mammary Gland Development
            Cyclopamine
            Cancer Research
            Oncology
            Surgical Oncology
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fbcr3401/MediaObjects/13058_2013_3197_Fig1_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fbcr3401/MediaObjects/13058_2013_3197_Fig2_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fbcr3401/MediaObjects/13058_2013_3197_Fig3_HTML.jpg
         isPartOf:
            name:Breast Cancer Research
            issn:
               1465-542X
            volumeNumber:15
            type:
               Periodical
               PublicationVolume
         publisher:
            name:BioMed Central
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Mun Hui
               affiliation:
                     name:Garvan Institute of Medical Research
                     address:
                        name:The Kinghorn Cancer Center and Cancer Res Division, Garvan Institute of Medical Research, Australia
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Aurélie Cazet
               affiliation:
                     name:Garvan Institute of Medical Research
                     address:
                        name:The Kinghorn Cancer Center and Cancer Res Division, Garvan Institute of Medical Research, Australia
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Radhika Nair
               affiliation:
                     name:Garvan Institute of Medical Research
                     address:
                        name:The Kinghorn Cancer Center and Cancer Res Division, Garvan Institute of Medical Research, Australia
                        type:PostalAddress
                     type:Organization
               type:Person
               name:D Neil Watkins
               affiliation:
                     name:Monash University
                     address:
                        name:Monash Institute of Medical Research, Monash University, Clayton, Australia
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Sandra A O'Toole
               affiliation:
                     name:Garvan Institute of Medical Research
                     address:
                        name:The Kinghorn Cancer Center and Cancer Res Division, Garvan Institute of Medical Research, Australia
                        type:PostalAddress
                     type:Organization
                     name:University of New South Wales
                     address:
                        name:St Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Australia
                        type:PostalAddress
                     type:Organization
                     name:Royal Prince Alfred Hospital
                     address:
                        name:Department of Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Camperdown, Australia
                        type:PostalAddress
                     type:Organization
                     name:Sydney Medical School, University of Sydney
                     address:
                        name:Sydney Medical School, University of Sydney, Australia
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Alexander Swarbrick
               affiliation:
                     name:Garvan Institute of Medical Research
                     address:
                        name:The Kinghorn Cancer Center and Cancer Res Division, Garvan Institute of Medical Research, Australia
                        type:PostalAddress
                     type:Organization
                     name:University of New South Wales
                     address:
                        name:St Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Australia
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:1
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:The Hedgehog signalling pathway in breast development, carcinogenesis and cancer therapy
      description:Despite the progress achieved in breast cancer screening and therapeutic innovations, the basal-like subtype of breast cancer (BLBC) still represents a particular clinical challenge. In order to make an impact on survival in this type of aggressive breast cancer, new targeted therapeutic agents are urgently needed. Aberrant activation of the Hedgehog (Hh) signalling pathway has been unambiguously tied to cancer development and progression in a variety of solid malignancies, and the recent approval of vismodegib, an orally bioavailable small-molecule inhibitor of Smoothened, validates Hh signalling as a valuable therapeutic target. A number of recent publications have highlighted a role for Hh signalling in breast cancer models and clinical specimens. Interestingly, Hh ligand overexpression is associated with the BLBC phenotype and a poor outcome in terms of metastasis and breast cancer-related death. In this review, we provide a comprehensive overview of the canonical Hh signalling pathway in mammals, highlight its roles in mammary gland development and breast carcinogenesis and discuss its potential therapeutic value in BLBC.
      datePublished:2013-03-28T00:00:00Z
      dateModified:2013-03-28T00:00:00Z
      pageStart:1
      pageEnd:14
      sameAs:https://doi.org/10.1186/bcr3401
      keywords:
         Breast Cancer
         Basal Cell Carcinoma
         Primary Cilium
         Mammary Gland Development
         Cyclopamine
         Cancer Research
         Oncology
         Surgical Oncology
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fbcr3401/MediaObjects/13058_2013_3197_Fig1_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fbcr3401/MediaObjects/13058_2013_3197_Fig2_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fbcr3401/MediaObjects/13058_2013_3197_Fig3_HTML.jpg
      isPartOf:
         name:Breast Cancer Research
         issn:
            1465-542X
         volumeNumber:15
         type:
            Periodical
            PublicationVolume
      publisher:
         name:BioMed Central
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Mun Hui
            affiliation:
                  name:Garvan Institute of Medical Research
                  address:
                     name:The Kinghorn Cancer Center and Cancer Res Division, Garvan Institute of Medical Research, Australia
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Aurélie Cazet
            affiliation:
                  name:Garvan Institute of Medical Research
                  address:
                     name:The Kinghorn Cancer Center and Cancer Res Division, Garvan Institute of Medical Research, Australia
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Radhika Nair
            affiliation:
                  name:Garvan Institute of Medical Research
                  address:
                     name:The Kinghorn Cancer Center and Cancer Res Division, Garvan Institute of Medical Research, Australia
                     type:PostalAddress
                  type:Organization
            type:Person
            name:D Neil Watkins
            affiliation:
                  name:Monash University
                  address:
                     name:Monash Institute of Medical Research, Monash University, Clayton, Australia
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Sandra A O'Toole
            affiliation:
                  name:Garvan Institute of Medical Research
                  address:
                     name:The Kinghorn Cancer Center and Cancer Res Division, Garvan Institute of Medical Research, Australia
                     type:PostalAddress
                  type:Organization
                  name:University of New South Wales
                  address:
                     name:St Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Australia
                     type:PostalAddress
                  type:Organization
                  name:Royal Prince Alfred Hospital
                  address:
                     name:Department of Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Camperdown, Australia
                     type:PostalAddress
                  type:Organization
                  name:Sydney Medical School, University of Sydney
                  address:
                     name:Sydney Medical School, University of Sydney, Australia
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Alexander Swarbrick
            affiliation:
                  name:Garvan Institute of Medical Research
                  address:
                     name:The Kinghorn Cancer Center and Cancer Res Division, Garvan Institute of Medical Research, Australia
                     type:PostalAddress
                  type:Organization
                  name:University of New South Wales
                  address:
                     name:St Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Australia
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:1
["Periodical","PublicationVolume"]:
      name:Breast Cancer Research
      issn:
         1465-542X
      volumeNumber:15
Organization:
      name:BioMed Central
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Garvan Institute of Medical Research
      address:
         name:The Kinghorn Cancer Center and Cancer Res Division, Garvan Institute of Medical Research, Australia
         type:PostalAddress
      name:Garvan Institute of Medical Research
      address:
         name:The Kinghorn Cancer Center and Cancer Res Division, Garvan Institute of Medical Research, Australia
         type:PostalAddress
      name:Garvan Institute of Medical Research
      address:
         name:The Kinghorn Cancer Center and Cancer Res Division, Garvan Institute of Medical Research, Australia
         type:PostalAddress
      name:Monash University
      address:
         name:Monash Institute of Medical Research, Monash University, Clayton, Australia
         type:PostalAddress
      name:Garvan Institute of Medical Research
      address:
         name:The Kinghorn Cancer Center and Cancer Res Division, Garvan Institute of Medical Research, Australia
         type:PostalAddress
      name:University of New South Wales
      address:
         name:St Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Australia
         type:PostalAddress
      name:Royal Prince Alfred Hospital
      address:
         name:Department of Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Camperdown, Australia
         type:PostalAddress
      name:Sydney Medical School, University of Sydney
      address:
         name:Sydney Medical School, University of Sydney, Australia
         type:PostalAddress
      name:Garvan Institute of Medical Research
      address:
         name:The Kinghorn Cancer Center and Cancer Res Division, Garvan Institute of Medical Research, Australia
         type:PostalAddress
      name:University of New South Wales
      address:
         name:St Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Australia
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Mun Hui
      affiliation:
            name:Garvan Institute of Medical Research
            address:
               name:The Kinghorn Cancer Center and Cancer Res Division, Garvan Institute of Medical Research, Australia
               type:PostalAddress
            type:Organization
      name:Aurélie Cazet
      affiliation:
            name:Garvan Institute of Medical Research
            address:
               name:The Kinghorn Cancer Center and Cancer Res Division, Garvan Institute of Medical Research, Australia
               type:PostalAddress
            type:Organization
      name:Radhika Nair
      affiliation:
            name:Garvan Institute of Medical Research
            address:
               name:The Kinghorn Cancer Center and Cancer Res Division, Garvan Institute of Medical Research, Australia
               type:PostalAddress
            type:Organization
      name:D Neil Watkins
      affiliation:
            name:Monash University
            address:
               name:Monash Institute of Medical Research, Monash University, Clayton, Australia
               type:PostalAddress
            type:Organization
      name:Sandra A O'Toole
      affiliation:
            name:Garvan Institute of Medical Research
            address:
               name:The Kinghorn Cancer Center and Cancer Res Division, Garvan Institute of Medical Research, Australia
               type:PostalAddress
            type:Organization
            name:University of New South Wales
            address:
               name:St Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Australia
               type:PostalAddress
            type:Organization
            name:Royal Prince Alfred Hospital
            address:
               name:Department of Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Camperdown, Australia
               type:PostalAddress
            type:Organization
            name:Sydney Medical School, University of Sydney
            address:
               name:Sydney Medical School, University of Sydney, Australia
               type:PostalAddress
            type:Organization
      name:Alexander Swarbrick
      affiliation:
            name:Garvan Institute of Medical Research
            address:
               name:The Kinghorn Cancer Center and Cancer Res Division, Garvan Institute of Medical Research, Australia
               type:PostalAddress
            type:Organization
            name:University of New South Wales
            address:
               name:St Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Australia
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:The Kinghorn Cancer Center and Cancer Res Division, Garvan Institute of Medical Research, Australia
      name:The Kinghorn Cancer Center and Cancer Res Division, Garvan Institute of Medical Research, Australia
      name:The Kinghorn Cancer Center and Cancer Res Division, Garvan Institute of Medical Research, Australia
      name:Monash Institute of Medical Research, Monash University, Clayton, Australia
      name:The Kinghorn Cancer Center and Cancer Res Division, Garvan Institute of Medical Research, Australia
      name:St Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Australia
      name:Department of Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Camperdown, Australia
      name:Sydney Medical School, University of Sydney, Australia
      name:The Kinghorn Cancer Center and Cancer Res Division, Garvan Institute of Medical Research, Australia
      name:St Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Australia

External Links {🔗}(367)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

7.03s.

LINK . SPRINGER . COM {}