We are analyzing https://link.springer.com/article/10.1186/bcr2851.

Title:
Jekyll or Hyde: does Matrigel provide a more or less physiological environment in mammary repopulating assays? | Breast Cancer Research
Description:
In vivo transplantation is the current
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28 years and 1 months (reg. 1997-05-29).

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Keywords {🔍}

cells, matrigel, mammary, cell, stem, pubmed, article, luminal, google, scholar, transplantation, outgrowths, cas, cancer, activity, data, progenitor, subset, breast, repopulating, assays, lindeman, visvader, matrix, shown, central, research, vaillant, population, nature, capacity, mascs, subpopulation, human, growth, number, vivo, mouse, fat, epithelial, mascenriched, glands, mice, privacy, cookies, function, masc, studies, transplanted, selfrenewal,

Topics {✒️}

engelbreth-holm-swarm mouse sarcoma fvb/n-rosa26 female mice enhance tumor-initiating capacity current 'gold-standard' assay luminal cell-fate commitment x-gal-stained outgrowths limited regenerative potential vivo regenerative ability altered extracellular matrix rare bipotent cells mammary stem cell growth factor-reduced matrigel mammary stem cells tumor stem cells cell stem cell cancer stem cells breast cancer res human breast cancers human breast carcinomas privacy choices/manage cookies single stem cell transplanted double-sorted cells moraes rc stem cell activity mouse sarcoma line human breast tissue reconstituted basement membrane functional mammary gland mammary repopulating frequency luminal progenitor cells unsorted mammary cells mammary epithelial outgrowths squamous cell carcinomas luminal cell-derived x-gal staining small branched structures masc-enriched basal population stem cells dev β-galactosidase activity mammary fat pad mammary repopulating assays mature luminal cells single cell suspensions provide tumor cells bona fide mascs fat pads transplanted luminal cell subset authors’ original file central point aberrant luminal progenitors

Questions {❓}

Bissell MJ, Labarge MA: Context, tissue plasticity, and cancer: are tumor stem cells also regulated by the microenvironment?
Jekyll or Hyde: does Matrigel provide a more or less physiological environment in mammary repopulating assays?
Jekyll or Hyde: does Matrigel provide a more or less physiological environment in mammary repopulating assays?

Schema {🗺️}

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         headline:Jekyll or Hyde: does Matrigel provide a more or less physiological environment in mammary repopulating assays?
         description:In vivo transplantation is the current 'gold-standard' assay for evaluating mammary stem cell (MaSC) function. Matrigel, a reconstituted extracellular matrix derived from a mouse sarcoma line, is increasingly being utilized for mammary repopulating assays, although original studies were carried out in its absence. This matrix has also been shown to enhance tumor-initiating capacity. Whilst Matrigel increases the rate of engraftment by MaSCs, it also appears to promote progenitor activity that is distinct from bona fide stem cell activity. This caveat should be considered when interpreting mammary reconstitution assays that incorporate Matrigel, particularly when transplanting high cell numbers.
         datePublished:2011-05-25T00:00:00Z
         dateModified:2011-05-25T00:00:00Z
         pageStart:1
         pageEnd:4
         sameAs:https://doi.org/10.1186/bcr2851
         keywords:
            Cancer Research
            Oncology
            Surgical Oncology
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      headline:Jekyll or Hyde: does Matrigel provide a more or less physiological environment in mammary repopulating assays?
      description:In vivo transplantation is the current 'gold-standard' assay for evaluating mammary stem cell (MaSC) function. Matrigel, a reconstituted extracellular matrix derived from a mouse sarcoma line, is increasingly being utilized for mammary repopulating assays, although original studies were carried out in its absence. This matrix has also been shown to enhance tumor-initiating capacity. Whilst Matrigel increases the rate of engraftment by MaSCs, it also appears to promote progenitor activity that is distinct from bona fide stem cell activity. This caveat should be considered when interpreting mammary reconstitution assays that incorporate Matrigel, particularly when transplanting high cell numbers.
      datePublished:2011-05-25T00:00:00Z
      dateModified:2011-05-25T00:00:00Z
      pageStart:1
      pageEnd:4
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      keywords:
         Cancer Research
         Oncology
         Surgical Oncology
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                  name:The University of Melbourne
                  address:
                     name:Department of Medical Biology, The University of Melbourne, Parkville, Australia
                     type:PostalAddress
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            name:Geoffrey J Lindeman
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                  name:The Walter and Eliza Hall Institute of Medical Research
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                     name:Stem Cells and Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
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               type:PostalAddress
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            address:
               name:Department of Medical Biology, The University of Melbourne, Parkville, Australia
               type:PostalAddress
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      affiliation:
            name:The Walter and Eliza Hall Institute of Medical Research
            address:
               name:Stem Cells and Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
               type:PostalAddress
            type:Organization
            name:The Royal Melbourne Hospital
            address:
               name:Department of Medical Oncology, The Royal Melbourne Hospital, Parkville, Australia
               type:PostalAddress
            type:Organization
            name:The University of Melbourne
            address:
               name:Department of Medicine, The University of Melbourne, Parkville, Australia
               type:PostalAddress
            type:Organization
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      affiliation:
            name:The Walter and Eliza Hall Institute of Medical Research
            address:
               name:Stem Cells and Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
               type:PostalAddress
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               name:Department of Medical Biology, The University of Melbourne, Parkville, Australia
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      name:Stem Cells and Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
      name:Department of Medical Biology, The University of Melbourne, Parkville, Australia
      name:Stem Cells and Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
      name:Department of Medical Oncology, The Royal Melbourne Hospital, Parkville, Australia
      name:Department of Medicine, The University of Melbourne, Parkville, Australia
      name:Stem Cells and Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
      name:Department of Medical Biology, The University of Melbourne, Parkville, Australia

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