
LINK . SPRINGER . COM {
}
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Title:
Triple-negative breast cancer | Breast Cancer Research
Description:
Perou
Website Age:
28 years and 1 months (reg. 1997-05-29).
Matching Content Categories {📚}
- Health & Fitness
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Link.springer.com is based on PIVOTX.
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Keywords {🔍}
cancer, breast, tumors, google, scholar, article, patients, cas, metastatic, phase, study, triplenegative, clinical, clin, treatment, combination, brca, growth, therapy, basaloid, showed, chemotherapy, receptor, oncol, response, factor, negative, months, res, inhibitors, survival, paclitaxel, inhibitor, results, iii, disease, abstract, higher, parp, randomized, suppl, tumor, time, epidermal, expression, table, molecular, rates, studies, colleagues,
Topics {✒️}
raf/mek/map kinase inhibitors hsp90 inhibitor pu-h71 org/breast-cancer-research triple-negative breast cancer 'triple-negative' breast cancer small-cell lung cancer recurrent/metastatic breast cancer brca-mutated breast cancer csf-1r-dependent osteolysis node-positive breast cancer called triple-negative phenotype grade iii hand-foot her2-positive breast cancer small-size tumors present org/professionals/physician_gls/f_guidelines cd44+/cd24– tumor cells brca-mutated ovarian cancer cd44+/cd24– phenotype relates brca1/2-mutated ovarian cancer newly diagnosed african-american single-institution compilation compared c-src protein expression glomeruloid microvascular proliferation triple negative state molecularly similar hormone receptor-positive tumors including breast cancer human breast cancer advanced breast cancer src tyrosine kinase tyrosine-kinase inhibitor median disease-free survival metastatic breast cancer metastasic breast carcinoma tyrosine kinase inhibitors specific targeted therapies 3-year disease-free rate her2-negative locally recurrent breast cancer models breast cancer subtypes human breast carcinoma median progression-free survival receive trastuzumab-based therapy invasive breast carcinoma familial breast cancer breast cancer res operable breast cancer triple-negative phenotype embryonic transcription factor targeted therapy
Questions {❓}
- Rakha EA, Tan DS, Foulkes WD, Ellis IO, Tutt A, Nielsen TO, Reis-Filho JS: Are triple negative tumours and basal-like breast cancer synonymous?
Schema {🗺️}
WebPage:
mainEntity:
headline:Triple-negative breast cancer
description:Perou's molecular classification defines tumors that neither express hormone receptors nor overexpress HER2 as triple-negative (TN) tumors. These tumors account for approximately 15% of breast cancers. The so-called basaloid tumors are not always synonymous with TN tumors; they differ in the fact that they express different molecular markers, have a higher histologic grade, and have a worse prognosis. Clinically they occur in younger women as interval cancer, and the risk of recurrence is higher within the first 3 years. Distant recurrences in the brain and visceral metastases are more common than in hormone receptor-positive tumors. Therapeutically, despite being highly chemosensitive, their progression-free time is generally short. In terms of chemotherapeutic treatment, anthracyclines and taxanes are useful drugs, and high response rates have been described for the combination of ixabepilone-capecitabine and platinums. The combination with antiangiogenic drugs has also proven useful. A group of new drugs, poly-(ADP-ribose)-polymerase inhibitors, showed favorable results in TN tumors with BRCA mutation. There are currently several ongoing studies with new drugs including epidermal growth factor receptor inhibitors, c-kit inhibitors, Raf/Mek/Map kinase inhibitors and mTOR inhibitors.
datePublished:2010-10-22T00:00:00Z
dateModified:2010-10-22T00:00:00Z
pageStart:1
pageEnd:9
sameAs:https://doi.org/10.1186/bcr2574
keywords:
Breast Cancer
Epidermal Growth Factor Receptor
Bevacizumab
Sorafenib
Metastatic Breast Cancer
Cancer Research
Oncology
Surgical Oncology
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isPartOf:
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issn:
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volumeNumber:12
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affiliation:
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address:
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ScholarlyArticle:
headline:Triple-negative breast cancer
description:Perou's molecular classification defines tumors that neither express hormone receptors nor overexpress HER2 as triple-negative (TN) tumors. These tumors account for approximately 15% of breast cancers. The so-called basaloid tumors are not always synonymous with TN tumors; they differ in the fact that they express different molecular markers, have a higher histologic grade, and have a worse prognosis. Clinically they occur in younger women as interval cancer, and the risk of recurrence is higher within the first 3 years. Distant recurrences in the brain and visceral metastases are more common than in hormone receptor-positive tumors. Therapeutically, despite being highly chemosensitive, their progression-free time is generally short. In terms of chemotherapeutic treatment, anthracyclines and taxanes are useful drugs, and high response rates have been described for the combination of ixabepilone-capecitabine and platinums. The combination with antiangiogenic drugs has also proven useful. A group of new drugs, poly-(ADP-ribose)-polymerase inhibitors, showed favorable results in TN tumors with BRCA mutation. There are currently several ongoing studies with new drugs including epidermal growth factor receptor inhibitors, c-kit inhibitors, Raf/Mek/Map kinase inhibitors and mTOR inhibitors.
datePublished:2010-10-22T00:00:00Z
dateModified:2010-10-22T00:00:00Z
pageStart:1
pageEnd:9
sameAs:https://doi.org/10.1186/bcr2574
keywords:
Breast Cancer
Epidermal Growth Factor Receptor
Bevacizumab
Sorafenib
Metastatic Breast Cancer
Cancer Research
Oncology
Surgical Oncology
image:
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name:Oncology Department, Instituto Alexander Fleming, Argentina
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email:[email protected]
name:María V Costanzo
affiliation:
name:Instituto Alexander Fleming
address:
name:Oncology Department, Instituto Alexander Fleming, Argentina
type:PostalAddress
type:Organization
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name:Oncology Department, Instituto Alexander Fleming, Argentina
name:Oncology Department, Instituto Alexander Fleming, Argentina
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