We are analyzing https://link.springer.com/article/10.1186/bcr1995.

Title:
Breast cancer risk in relation to urinary and serum biomarkers of phytoestrogen exposure in the European Prospective into Cancer-Norfolk cohort study | Breast Cancer Research
Description:
Introduction Phytoestrogens are a group of compounds found in plants that structurally resemble the hormone oestradiol, and thus have the potential to act as oestrogen agonists or antagonists. Their potential effects may alter the risk of breast cancer, but only a limited range of phytoestrogens has been examined in prospective cohort studies. Methods Serum and urine samples from 237 incident breast cancer cases and 952 control individuals (aged 45 to 75 years) in the European Prospective into Cancer-Norfolk cohort were analysed for seven phytoestrogens (daidzein, enterodiol, enterolactone, genistein, glycitein, o-desmethylangolensin, and equol) using liquid chromatography/mass spectrometry. Data on participants
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Keywords {🔍}

cancer, breast, risk, study, google, scholar, pubmed, serum, phytoestrogens, cas, phytoestrogen, article, urinary, cases, equol, biomarkers, levels, analysis, data, cohort, prospective, enterolactone, samples, women, status, daidzein, dietary, epicnorfolk, present, genistein, intake, european, urine, isoflavones, research, exposure, studies, control, higher, health, oestrogen, individuals, plasma, erpositive, table, nutr, bingham, total, methods, spectrometry,

Topics {✒️}

kay-tee khaw & sheila bingham gas chromatography/mass spectrometry liquid chromatography/mass spectrometry article download pdf endogenous sex hormones heather ward hydroxyl radical-scavenging property average intra-assay coefficient wilcoxon–mann–whitney test incident case-referent study er-positive tumour status involve diet-gene interactions cancer-norfolk cohort study nested case-control study daidzein-metabolizing phenotypes differs tyrosine-specific protein kinases er-negative breast cancer er-positive breast cancer article ward oestrogen-sensitive breast cancers prospective epic-norfolk cohort oestrogen receptor-positive tumours gunter gc kuhnle er-positive cancer risk breast cancer warrants author information authors full access privacy choices/manage cookies cancer-norfolk cohort medical research council 13c-labeled tracers estrogen receptor beta french cohort study invasive breast cancer norfolk cohort study mol cell biochem er-positive cohort progesterone receptor status epic-norfolk cohort [25] epic-norfolk cohort epic-norfolk cohort [4] strangeways research laboratory estrogen receptor status intra-assay coefficient plant-protective compounds breast cancer mastectomy breast cancer chemoprevention breast cancer survivors van de pb case–control comparisons

Questions {❓}

Bingham SA, Atkinson C, Liggins J, Bluck L, Coward A: Phyto-oestrogens: where are we now?
Brzezinski A, Debi A: Phytoestrogens: the "natural" selective estrogen receptor modulators?

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         description:Phytoestrogens are a group of compounds found in plants that structurally resemble the hormone oestradiol, and thus have the potential to act as oestrogen agonists or antagonists. Their potential effects may alter the risk of breast cancer, but only a limited range of phytoestrogens has been examined in prospective cohort studies. Serum and urine samples from 237 incident breast cancer cases and 952 control individuals (aged 45 to 75 years) in the European Prospective into Cancer-Norfolk cohort were analysed for seven phytoestrogens (daidzein, enterodiol, enterolactone, genistein, glycitein, o-desmethylangolensin, and equol) using liquid chromatography/mass spectrometry. Data on participants' diet, demographics, anthropometrics, and medical history were collected upon recruitment. All models were adjusted for weight, fat and energy intake, family history of breast cancer, social class, analytical batch, and factors related to oestrogen exposure. Urinary or serum phytoestrogens were not associated with protection from breast cancer in the European Prospective into Cancer-Norfolk cohort. Breast cancer risk was marginally increased with higher levels of total urinary isoflavones (odds ratio = 1.08 (95% confidence interval = 1.00 to 1.16), P = 0.055); among those with oestrogen receptor-positive tumours, the risk of breast cancer was increased with higher levels of urinary equol (odds ratio = 1.07 (95% confidence interval = 1.01 to 1.12), P = 0.013). There was limited evidence of an association between phytoestrogen biomarkers and breast cancer risk in the present study. There was no indication of decreased likelihood of breast cancer with higher levels of phytoestrogen biomarkers, but the observation that some phytoestrogen biomarkers may be associated with greater risk of breast cancer warrants further study with greater statistical power.
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