We are analyzing https://link.springer.com/article/10.1186/bcr1994.

Title:
Vitamin D receptor gene polymorphisms and haplotypes and postmenopausal breast cancer risk | Breast Cancer Research
Description:
Introduction Vitamin D receptor (VDR) genotypes may influence breast cancer risk by altering potential anticarcinogenic effects of vitamin D, but epidemiological studies have been inconsistent. Effect modification by serum 25-hydroxyvitamin D (25 [OH]D), the biomarker for vitamin D status in humans, has rarely been examined. Methods We assessed the effects of two frequently analyzed polymorphisms (FokI and TaqI) and two potentially functional variants (VDR-5132 and Cdx2) in the VDR gene, which thus far have not been analyzed with respect to breast cancer risk, on postmenopausal breast cancer risk in a population-based, case-control study including 1,408 patients (cases) and 2,612 control individuals (controls) matched for year of birth. Odds ratios (ORs) for breast cancer adjusted for potential confounders were calculated for genotypes and estimated haplotypes. Results No differences in serum 25(OD)D concentrations by VDR genotype were observed. None of the analyzed polymorphisms was associated with overall risk for postmenopausal breast cancer. However, the TaqI polymorphism was associated with a significantly increased risk for oestrogen receptor positive tumours (OR = 1.18, 95% confidence interval [CI] = 1.00 to 1.38, comparing t allele carriers with noncarriers) but not for oestrogen receptor negative tumours (OR = 0.88, 95% CI = 0.69 to 1.13; P for interaction = 0.04). Haplotype analysis revealed the haplotype FtCA (FokI F, TaqI t, VDR-5132 C, Cdx2 A), which contains the TaqI t allele, to be associated with a significantly greater breast cancer risk as compared with the most frequent haplotype FTCG (OR = 1.43, 95% CI = 1.00 to 2.05). No significant interaction between VDR genotypes or haplotypes and 25(OH)D was observed. Conclusion Our results support potential effects of VDR polymorphisms on postmenopausal breast cancer risk and possible differential effects of receptor status of the tumour. However, further studies focusing on the influence of polymorphisms and haplotypes on VDR functionality, activity and concentration are needed.
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Keywords {🔍}

cancer, breast, risk, vitamin, vdr, polymorphisms, article, receptor, ohd, pubmed, google, scholar, cas, gene, haplotype, study, taqi, interaction, polymorphism, postmenopausal, status, analysis, allele, haplotypes, cdx, association, studies, serum, cases, effects, foki, significant, controls, genotype, table, analyzed, potential, res, results, observed, model, data, significantly, tumour, tumours, women, region, years, including, hydroxyvitamin,

Topics {✒️}

jenny chang-claude article download pdf early-onset breast cancer log-additive risk model post-menopausal breast cancer nurses health study nested case-control study case-control study nested elke jonny mutschelknauss large case-control study 2d-transcription factor complex er-positive tumours suggest retrospective case-control design rhein-neckar-karlsruhe snp assessing genetic variations flesch-janys breast cancer risk postmenopausal breast cancer participant-level meta-analysis significantly higher risk sporadic breast cancer significantly increased risk university clinic hamburg-eppendorf endocrine-related cancer log-additive model full access privacy choices/manage cookies significant gene-environment interaction breast cancer prognosis breast cancer progression statistical haplotype-environment interaction large sample size related subjects statistical genotype-environment interaction breast cancer res statistically significantly increased 25-dihydroxyvitamin d3 receptors established risk factors rhein-neckar-karlsruhe hardy-weinberg equilibrium high chang-claude oestrogen-mediated anticarcinogenic effect article number r31 breast cancer patients breast cancer adjusted positive family history breast feeding history prostate cancer risk suppresses estrogen actions

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         headline:Vitamin D receptor gene polymorphisms and haplotypes and postmenopausal breast cancer risk
         description:Vitamin D receptor (VDR) genotypes may influence breast cancer risk by altering potential anticarcinogenic effects of vitamin D, but epidemiological studies have been inconsistent. Effect modification by serum 25-hydroxyvitamin D (25 [OH]D), the biomarker for vitamin D status in humans, has rarely been examined. We assessed the effects of two frequently analyzed polymorphisms (FokI and TaqI) and two potentially functional variants (VDR-5132 and Cdx2) in the VDR gene, which thus far have not been analyzed with respect to breast cancer risk, on postmenopausal breast cancer risk in a population-based, case-control study including 1,408 patients (cases) and 2,612 control individuals (controls) matched for year of birth. Odds ratios (ORs) for breast cancer adjusted for potential confounders were calculated for genotypes and estimated haplotypes. No differences in serum 25(OD)D concentrations by VDR genotype were observed. None of the analyzed polymorphisms was associated with overall risk for postmenopausal breast cancer. However, the TaqI polymorphism was associated with a significantly increased risk for oestrogen receptor positive tumours (OR = 1.18, 95% confidence interval [CI] = 1.00 to 1.38, comparing t allele carriers with noncarriers) but not for oestrogen receptor negative tumours (OR = 0.88, 95% CI = 0.69 to 1.13; P for interaction = 0.04). Haplotype analysis revealed the haplotype FtCA (FokI F, TaqI t, VDR-5132 C, Cdx2 A), which contains the TaqI t allele, to be associated with a significantly greater breast cancer risk as compared with the most frequent haplotype FTCG (OR = 1.43, 95% CI = 1.00 to 2.05). No significant interaction between VDR genotypes or haplotypes and 25(OH)D was observed. Our results support potential effects of VDR polymorphisms on postmenopausal breast cancer risk and possible differential effects of receptor status of the tumour. However, further studies focusing on the influence of polymorphisms and haplotypes on VDR functionality, activity and concentration are needed.
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      headline:Vitamin D receptor gene polymorphisms and haplotypes and postmenopausal breast cancer risk
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