We are analyzing https://link.springer.com/article/10.1186/bcr1834.

Title:
Regulator of G-protein signalling 2 mRNA is differentially expressed in mammary epithelial subpopulations and over-expressed in the majority of breast cancers | Breast Cancer Research
Description:
Introduction To understand which signalling pathways become deregulated in breast cancer, it is necessary to identify functionally significant gene expression patterns in the stem, progenitor, transit amplifying and differentiated cells of the mammary epithelium. We have previously used the markers 33A10, CD24 and Sca-1 to identify mouse mammary epithelial cell subpopulations. We now investigate the relationship between cells expressing these markers and use gene expression microarray analysis to identify genes differentially expressed in the cell populations. Methods Freshly isolated primary mouse mammary epithelial cells were separated on the basis of staining with the 33A10 antibody and an α-Sca-1 antibody. The populations identified were profiled using gene expression microarray analysis. Gene expression patterns were confirmed on normal mouse and human mammary epithelial subpopulations and were examined in a panel of breast cancer samples and cell lines. Results Analysis of the separated populations demonstrated that Sca-1- 33A10High stained cells were estrogen receptor α (Esr1)- luminal epithelial cells, whereas Sca-1+ 33A10Low/- stained cells were a mix of nonepithelial cells and Esr1+ epithelial cells. Analysis of the gene expression data identified the gene Rgs2 (regulator of G-protein signalling 2) as being highly expressed in the Sca-1- 33A10Low/- population, which included myoepithelial/basal cells. RGS2 has previously been described as a regulator of angiotensin II receptor signalling. Gene expression analysis by quantitative real-time RT-PCR of cells separated on the basis of CD24 and Sca-1 expression confirmed that Rgs2 was more highly expressed in mouse myoepithelial/basal mammary cells than luminal cells. This expression pattern was conserved in normal human breast cells. Functional analysis demonstrated RGS2 to be a modulator of oxytocin receptor signalling. The potential significance of RGS2 expression in breast cancer was demonstrated by semi-quantitative RT-PCR analysis, data mining and quantitative real-time RT-PCR approaches, which showed that RGS2 was expressed in the majority of solid breast cancers at much higher levels than in normal human mammary cells. Conclusion Molecular analysis of prospectively isolated mammary epithelial cells identified RGS2 as a modulator of oxytocin receptor signalling, which is highly expressed in the myoepithelial cells. The RGS2 gene, but not the oxytocin receptor, was also shown to be over-expressed in the majority of breast cancers, identifying the product of this gene, or the pathway(s) it regulates, as potentially significant therapeutic targets.
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Keywords {🔍}

cells, rgs, cell, expression, mammary, breast, epithelial, luminal, sca, gene, analysis, pubmed, cancer, article, oxytocin, mouse, google, scholar, signalling, receptor, human, data, cas, samples, populations, normal, myoepithelial, lines, esr, figure, genes, primary, cancers, alow, mapk, expressed, isolated, population, compared, microarray, levels, ahigh, rna, file, fibroblasts, cdhigh, pathways, significant, tumour, staining,

Topics {✒️}

α-sca-1/33a10/α-cd45/α-cd24 stained cells rat anti-mouse cd45-pe-cy5 quantitative real-time rt-pcr semi-quantitative rt-pcr analysis anti-sca-1/33a10/anti-cd24 sorting α-sca-1/33a10/α-cd45 sv40 large t-antigen g-protein-coupled receptors semi-quantitative rt-pcr oliveira-dos-santos quantitative real-time pcr g-protein coupled receptor alan mackay & alan ashworth author information authors mouse mammary basal/myoepithelial article download pdf cd24low basal/myoepithelial cells cd24low sca-1- basal/myoepithelial αβγ g-protein heterotrimers pcr-topo-xl kit quantitative rt-pcr experiments wild-type hs578t cells anti-cd24-pe-cy5 anti-cd24 staining identifies kara britt fluo-3/fura red system fluorescence-activated cell sorting protein-coupled receptors small gtpase-activating protein differentiated milk-secreting cells anita grigoriadis 33a10 staining profiles genome-wide expression profiling print-tip lowess normalization sca-1-/33a10high mammary cells fluo-3/fura red fluorescence sca-1+/33a10low/- mammary cells sca-1-/33a10low/- mammary cells endocrine-responsive breast cancer accession number e-mexp-423 basal/myoepithelial cells compared professor mike o'hare multi-tasking rgs proteins author correspondence nonspecific igg-stained control included myoepithelial/basal cells bulk mammary cell smooth muscle contraction full size image single stem cell

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Riddle EL, Schwartzman RA, Bond M, Insel PA: Multi-tasking RGS proteins in the heart: the next therapeutic target?

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            Myoepithelial Cell
            Luminal Epithelial Cell
            Oxytocin Receptor
            Hs578T Cell
            Cancer Research
            Oncology
            Surgical Oncology
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      headline:Regulator of G-protein signalling 2 mRNA is differentially expressed in mammary epithelial subpopulations and over-expressed in the majority of breast cancers
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         Myoepithelial Cell
         Luminal Epithelial Cell
         Oxytocin Receptor
         Hs578T Cell
         Cancer Research
         Oncology
         Surgical Oncology
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