We are analyzing https://link.springer.com/article/10.1186/bcr1745.

Title:
Inflammation and breast cancer. Inflammatory component of mammary carcinogenesis in ErbB2 transgenic mice | Breast Cancer Research
Description:
This review addresses genes differentially expressed in the mammary gland transcriptome during the progression of mammary carcinogenesis in BALB/c mice that are transgenic for the rat neu (ERBB2, or HER-2/neu) oncogene (BALB-neuT664V-E mice). The Ingenuity knowledge database was used to characterize four functional association networks whose hub genes are directly linked to inflammation (specifically, the genes encoding IL-1β, tumour necrosis factor, interferon-γ, and monocyte chemoattractant protein-1/CC chemokine ligand-2) and are increasingly expressed during such progression. In silico meta-analysis in a human breast cancer dataset suggests that proinflammatory activation in the mammary glands of these mice reflects a general pattern of human breast cancer.
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Keywords {🔍}

cancer, tumour, mammary, pubmed, google, scholar, mice, genes, gene, article, cas, expression, carcinogenesis, breast, forni, progression, figure, cells, inflammation, microenvironment, neu, cell, ifnγ, data, inflammatory, transgenic, balbneutve, cavallo, gatms, ingenuity, functional, tnf, authors, database, cytokines, interleukin, musiani, analysis, association, chemokine, tumor, ilβ, human, proinflammatory, shown, growth, ccl, mcpccl, full, giovarelli,

Topics {✒️}

granulocyte-macrophage colony-stimulating factor tumour-induced angiogenic switch lymphokine-activated tumor inhibition genome-wide mouse arrays guido forni & federica cavallo lec/ccl16 rapidly neutralize marked anti-angiogenic activity dominant regulatory t-cell nf-kappab italian ministero dell'università tumor-specific immune memory powerful anti-tumour activity chemokine-based pathogenetic mechanisms tumor necrosis factor-alpha //breast-cancer-research inflammation-related gene signature inflammation-related reaction elicited gene encoding mcp-1/ccl2 mcp-1/ccl2 chemokine increases cell-mediated tumor rejection erbb signalling network ifn-gamma-producing ts/ c-erbb-2 transgenic balb/ central driving force cytokine-induced tumor immunogenicity full size image pair-wise correlation comparison metastatic murine adenocarcinoma neu-driven autochthonous carcinogenesis monocyte chemoattractant protein machine learning ifn-γ knockout mice adenocarcinoma cells engineered tsa-ifn-γ cells [10] tumor-bearing mice inhibit functional association networks long-lasting response anti-tumour vaccines privacy choices/manage cookies authors’ original file il-12 induced ifn-γ study addressed balb-neut664v human breast cancer transcription profiling search ingenuity knowledge database cc chemokine ligand breast cancer pathophysiologies mcp-1/ccl2 hub genes differentiates acute inflammation acute tumour destruction

Questions {❓}

Krieg AM: CpG motifs: the active ingredient in bacterial extracts?

Schema {🗺️}

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         description:This review addresses genes differentially expressed in the mammary gland transcriptome during the progression of mammary carcinogenesis in BALB/c mice that are transgenic for the rat neu (ERBB2, or HER-2/neu) oncogene (BALB-neuT664V-E mice). The Ingenuity knowledge database was used to characterize four functional association networks whose hub genes are directly linked to inflammation (specifically, the genes encoding IL-1β, tumour necrosis factor, interferon-γ, and monocyte chemoattractant protein-1/CC chemokine ligand-2) and are increasingly expressed during such progression. In silico meta-analysis in a human breast cancer dataset suggests that proinflammatory activation in the mammary glands of these mice reflects a general pattern of human breast cancer.
         datePublished:2007-08-10T00:00:00Z
         dateModified:2007-08-10T00:00:00Z
         pageStart:1
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            Tumour Microenvironment
            Mammary Carcinogenesis
            Angiogenic Switch
            Functional Association Network
            Cancer Research
            Oncology
            Surgical Oncology
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      headline:Inflammation and breast cancer. Inflammatory component of mammary carcinogenesis in ErbB2 transgenic mice
      description:This review addresses genes differentially expressed in the mammary gland transcriptome during the progression of mammary carcinogenesis in BALB/c mice that are transgenic for the rat neu (ERBB2, or HER-2/neu) oncogene (BALB-neuT664V-E mice). The Ingenuity knowledge database was used to characterize four functional association networks whose hub genes are directly linked to inflammation (specifically, the genes encoding IL-1β, tumour necrosis factor, interferon-γ, and monocyte chemoattractant protein-1/CC chemokine ligand-2) and are increasingly expressed during such progression. In silico meta-analysis in a human breast cancer dataset suggests that proinflammatory activation in the mammary glands of these mice reflects a general pattern of human breast cancer.
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      dateModified:2007-08-10T00:00:00Z
      pageStart:1
      pageEnd:9
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         Tumour Microenvironment
         Mammary Carcinogenesis
         Angiogenic Switch
         Functional Association Network
         Cancer Research
         Oncology
         Surgical Oncology
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            type:Organization
      name:Francesca Cordero
      affiliation:
            name:Molecular Biotechnology Center
            address:
               name:Department of Clinical and Biological Sciences, Molecular Biotechnology Center, Turin, Italy
               type:PostalAddress
            type:Organization
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      affiliation:
            name:Molecular Biotechnology Center
            address:
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               type:PostalAddress
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