
LINK . SPRINGER . COM {
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Title:
Pilot phase III immunotherapy study in early-stage breast cancer patients using oxidized mannan-MUC1 [ISRCTN71711835] | Breast Cancer Research
Description:
Introduction Mucin 1 (MUC1) is a high molecular weight glycoprotein overexpressed on adenocarcinoma cells and is a target for immunotherapy protocols. To date, clinical trials against MUC1 have included advanced cancer patients. Herein, we report a trial using early stage breast cancer patients and injection of oxidized mannan-MUC1. Method In a randomized, double-blind study, 31 patients with stage II breast cancer and with no evidence of disease received subcutaneous injections of either placebo or oxidized mannan-MUC1, to immunize against MUC1 and prevent cancer reoccurrence/metastases. Twenty-eight patients received the full course of injections of either oxidized mannan-MUC1 or placebo. Survival and immunological assays were assessed. Results After more than 5.5 years had elapsed since the last patient began treatment (8.5 years from the start of treatment of the first patient), the recurrence rate in patients receiving the placebo was 27% (4/15; the expected rate of recurrence in stage II breast cancer); those receiving immunotherapy had no recurrences (0/16), and this finding was statistically significant (P = 0.0292). Of the patients receiving oxidized mannan-MUC1, nine out of 13 had measurable antibodies to MUC1 and four out of 10 had MUC1-specific T cell responses; none of the placebo-treated patients exhibited an immune response to MUC1. Conclusion The results suggest that, in early breast cancer, MUC1 immunotherapy is beneficial, and that a larger phase III study should be undertaken.
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patients, muc, cancer, pubmed, google, scholar, cas, article, responses, mfp, breast, apostolopoulos, patient, mckenzie, antibody, months, immune, cells, placebo, injection, samples, disease, study, cell, protein, years, table, response, immunotherapy, number, pietersz, tumour, pvntr, mucin, oxidized, antigen, positive, control, serum, vntr, mannan, immunized, trial, fusion, figure, mannanmuc, clinical, ifnΞ³, human, immunol,
Topics {βοΈ}
endogenous immune response survival/disease-free interval advantage von mensdorff-pouilly oxidized mannan-muc1 [isrctn71711835] glutathione-s-transferase ifn human muc1 vaccines cross-linking mannose receptors early-stage breast cancer prevent cancer reoccurrence/metastases kaplan-meier survival curves high-molecular-weight glycoproteins hla-a2-restricted ctls double-blind pilot study article download pdf partial mastectomy anti-vntr antibody response superior clinical outcomes hla-a11-restricted epitope pre-existing peptide-reactive cell-mediated immune responses muc1-mannan fusion protein mannan-muc1 fusion protein monoclonal antibody co17-1a anti-muc1 vntr antibodies detect ifn-Ξ³ responses detectable anti-vntr antibody recombinant ny-eso-1 protein related subjects muc1-specific immune responses mhc-restricted ctl epitopes author information authors glutathione-s-transferase modified radical mastectomy vasso apostolopoulos affiliations immunology excised lymph nodes dissected lymph nodes early breast cancer m-fp clinical trials human ab serum anti-tumor response privacy choices/manage cookies primary breast cancer polymorphic epithelial mucin monoclonal antibodies reactive lymph nodes involved m-fp immunized patients muc1 cytotoxic t-cells humoral immune response m-fp vaccinated group
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- MUC1 in Cancer Immunotherapy β New Hope or Phantom Menace?
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WebPage:
mainEntity:
headline:Pilot phase III immunotherapy study in early-stage breast cancer patients using oxidized mannan-MUC1 [ISRCTN71711835]
description:Mucin 1 (MUC1) is a high molecular weight glycoprotein overexpressed on adenocarcinoma cells and is a target for immunotherapy protocols. To date, clinical trials against MUC1 have included advanced cancer patients. Herein, we report a trial using early stage breast cancer patients and injection of oxidized mannan-MUC1. In a randomized, double-blind study, 31 patients with stage II breast cancer and with no evidence of disease received subcutaneous injections of either placebo or oxidized mannan-MUC1, to immunize against MUC1 and prevent cancer reoccurrence/metastases. Twenty-eight patients received the full course of injections of either oxidized mannan-MUC1 or placebo. Survival and immunological assays were assessed. After more than 5.5 years had elapsed since the last patient began treatment (8.5 years from the start of treatment of the first patient), the recurrence rate in patients receiving the placebo was 27% (4/15; the expected rate of recurrence in stage II breast cancer); those receiving immunotherapy had no recurrences (0/16), and this finding was statistically significant (P = 0.0292). Of the patients receiving oxidized mannan-MUC1, nine out of 13 had measurable antibodies to MUC1 and four out of 10 had MUC1-specific T cell responses; none of the placebo-treated patients exhibited an immune response to MUC1. The results suggest that, in early breast cancer, MUC1 immunotherapy is beneficial, and that a larger phase III study should be undertaken.
datePublished:2006-06-15T00:00:00Z
dateModified:2006-06-15T00:00:00Z
pageStart:1
pageEnd:11
license:http://creativecommons.org/licenses/by/2.0/
sameAs:https://doi.org/10.1186/bcr1505
keywords:
Breast Cancer
MUC1 Expression
Partial Mastectomy
Excise Lymph Node
Endogenous Immune Response
Cancer Research
Oncology
Surgical Oncology
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headline:Pilot phase III immunotherapy study in early-stage breast cancer patients using oxidized mannan-MUC1 [ISRCTN71711835]
description:Mucin 1 (MUC1) is a high molecular weight glycoprotein overexpressed on adenocarcinoma cells and is a target for immunotherapy protocols. To date, clinical trials against MUC1 have included advanced cancer patients. Herein, we report a trial using early stage breast cancer patients and injection of oxidized mannan-MUC1. In a randomized, double-blind study, 31 patients with stage II breast cancer and with no evidence of disease received subcutaneous injections of either placebo or oxidized mannan-MUC1, to immunize against MUC1 and prevent cancer reoccurrence/metastases. Twenty-eight patients received the full course of injections of either oxidized mannan-MUC1 or placebo. Survival and immunological assays were assessed. After more than 5.5 years had elapsed since the last patient began treatment (8.5 years from the start of treatment of the first patient), the recurrence rate in patients receiving the placebo was 27% (4/15; the expected rate of recurrence in stage II breast cancer); those receiving immunotherapy had no recurrences (0/16), and this finding was statistically significant (P = 0.0292). Of the patients receiving oxidized mannan-MUC1, nine out of 13 had measurable antibodies to MUC1 and four out of 10 had MUC1-specific T cell responses; none of the placebo-treated patients exhibited an immune response to MUC1. The results suggest that, in early breast cancer, MUC1 immunotherapy is beneficial, and that a larger phase III study should be undertaken.
datePublished:2006-06-15T00:00:00Z
dateModified:2006-06-15T00:00:00Z
pageStart:1
pageEnd:11
license:http://creativecommons.org/licenses/by/2.0/
sameAs:https://doi.org/10.1186/bcr1505
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Breast Cancer
MUC1 Expression
Partial Mastectomy
Excise Lymph Node
Endogenous Immune Response
Cancer Research
Oncology
Surgical Oncology
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