We are analyzing https://link.springer.com/article/10.1186/bcr1041.

Title:
Basal cytokeratins and their relationship to the cellular origin and functional classification of breast cancer | Breast Cancer Research
Description:
Recent publications have classified breast cancers on the basis of expression of cytokeratin-5 and -17 at the RNA and protein levels, and demonstrated the importance of these markers in defining sporadic tumours with bad prognosis and an association with BRCA1-related breast cancers. These important observations using different technology platforms produce a new functional classification of breast carcinoma. However, it is important in developing hypotheses about the pathogenesis of this tumour type to review the nomenclature that is being used to emphasize potential confusion between terminology that defines clinical subgroups and markers of cell lineage. This article reviews the lineages in the normal breast in relation to what have become known as the
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Keywords {🔍}

breast, cells, cell, pubmed, article, expression, google, scholar, cancer, cas, basal, tumours, luminal, normal, myoepithelial, epithelial, human, cytokeratins, carcinomas, gene, coworkers, cytokeratin, cancers, stratified, origin, demonstrated, markers, keratins, clinical, population, stem, expressed, central, classification, mammary, signature, res, basallike, express, identified, study, molecular, pathol, analysis, data, gusterson, types, moll, defined, differentiation,

Topics {✒️}

smooth muscle actin smooth muscle cells pragmatic marker-driven approach abd el-rehim high-molecular-weight cytokeratins ck5 cell shape-related regulation mediate cell–cell interactions x-linked inactivation studies steroid receptor-positive cells brca1-related breast cancers high-molecular-weight cytokeratins o'hare mj recent translational research reis-filho js cell-type-specific responses basaloid/myoepithelial cell differentiation cell growth differ progenitor/stem cells derived van de rijn c-erbb-2 expressing tumours human breast carcinoma privacy choices/manage cookies putative stem cell gene expression signature natl cancer inst invasive breast carcinoma gene expression signatures stem cell regulator human breast cancer cell line models human mammary gland differentiated cell types gene array experiments authors’ original file classified breast cancers breast cancers fell stratified epithelial cytokeratins gene expression experiments gene expression profiles stratified epithelial keratins quantitative genomic abnormalities nagle rb de carvalho lv breast cancer genetics gene expression patterns tailored treatment approaches breast cancer res stem cell populations multiple independent studies basal breast cancers

Questions {❓}

Behbod F, Rosen JM: Will cancer stem cells provide new therapeutic targets?
Lineages in the normal breast?
What is the clinical significance of cytokeratin defined subtypes of breast cancer?
Wilson CA, Dering J: Recent translational research: microarray expression profiling of breast cancer – beyond classification and prognostic markers?

Schema {🗺️}

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         headline:Basal cytokeratins and their relationship to the cellular origin and functional classification of breast cancer
         description:Recent publications have classified breast cancers on the basis of expression of cytokeratin-5 and -17 at the RNA and protein levels, and demonstrated the importance of these markers in defining sporadic tumours with bad prognosis and an association with BRCA1-related breast cancers. These important observations using different technology platforms produce a new functional classification of breast carcinoma. However, it is important in developing hypotheses about the pathogenesis of this tumour type to review the nomenclature that is being used to emphasize potential confusion between terminology that defines clinical subgroups and markers of cell lineage. This article reviews the lineages in the normal breast in relation to what have become known as the 'basal-like' carcinomas.
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      headline:Basal cytokeratins and their relationship to the cellular origin and functional classification of breast cancer
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         Epidermal Growth Factor Receptor
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         Smooth Muscle Actin
         Gene Expression Signature
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         Oncology
         Surgical Oncology
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